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Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
scientific journal article
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scholarly article
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PubMed
PubMed ID
15820682
retrieved
25 January 2017
title
Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation
(English)
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PubMed
PubMed ID
15820682
retrieved
25 January 2017
main subject
osteoblast
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Transforming growth factor, beta receptor I
1 reference
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GOA release 2020-03-11
Transforming growth factor, beta 1
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GOA release 2020-03-11
DNA-binding protein inhibitor ID-1
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stated in
GOA release 2020-03-11
Bone morphogenetic protein 2
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GOA release 2020-03-11
Mitogen-activated protein kinase 8
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stated in
GOA release 2020-03-11
SMAD specific E3 ubiquitin protein ligase 1
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stated in
GOA release 2020-03-11
author name string
Motozo Yamashita
series ordinal
1
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PubMed
PubMed ID
15820682
retrieved
25 January 2017
Sai-Xia Ying
series ordinal
2
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PubMed
PubMed ID
15820682
retrieved
25 January 2017
Gen-Mu Zhang
series ordinal
3
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stated in
PubMed
PubMed ID
15820682
retrieved
25 January 2017
Cuiling Li
series ordinal
4
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stated in
PubMed
PubMed ID
15820682
retrieved
25 January 2017
Steven Y. Cheng
series ordinal
5
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PubMed
PubMed ID
15820682
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25 January 2017
Chu-Xia Deng
series ordinal
6
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PubMed
PubMed ID
15820682
retrieved
25 January 2017
Ying E. Zhang
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7
1 reference
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PubMed
PubMed ID
15820682
retrieved
25 January 2017
language of work or name
English
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publication date
8 April 2005
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PubMed
PubMed ID
15820682
retrieved
25 January 2017
published in
Cell
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PubMed
PubMed ID
15820682
retrieved
25 January 2017
volume
121
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PubMed
PubMed ID
15820682
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25 January 2017
page(s)
101–113
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PubMed
PubMed ID
15820682
retrieved
25 January 2017
issue
1
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PubMed
PubMed ID
15820682
retrieved
25 January 2017
cites work
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Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells
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Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
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Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation
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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
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19 March 2017
AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element
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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
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PubMed Central
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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
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PubMed Central
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Signal transduction by the JNK group of MAP kinases
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PubMed Central
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19 March 2017
Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling
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19 March 2017
Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation
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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
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Smads bind directly to the Jun family of AP-1 transcription factors
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19 March 2017
ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling
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Function of WW domains as phosphoserine- or phosphothreonine-binding modules
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19 March 2017
Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor beta
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XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
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19 March 2017
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
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PubMed Central
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19 March 2017
Novel regulators of bone formation: molecular clones and activities
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PubMed Central
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19 March 2017
TGF beta signals through a heteromeric protein kinase receptor complex
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PubMed Central
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19 March 2017
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
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PubMed Central
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The Fos-related antigen Fra-1 is an activator of bone matrix formation
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29 September 2017
ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome
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29 September 2017
Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo
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PubMed Central
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Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice
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29 September 2017
Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation
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PubMed Central
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29 September 2017
Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads
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PubMed Central
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29 September 2017
E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation
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PubMed Central
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29 September 2017
RUNX transcription factors as key targets of TGF-beta superfamily signaling
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PubMed Central
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29 September 2017
Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294
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29 September 2017
Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses
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PubMed Central
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29 September 2017
Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators
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PubMed Central
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29 September 2017
TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses
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PubMed Central
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29 September 2017
Bone morphogenetic protein receptor signaling is necessary for normal murine postnatal bone formation
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PubMed Central
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29 September 2017
Reaching a genetic and molecular understanding of skeletal development
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PubMed Central
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29 September 2017
TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
1 reference
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PubMed Central
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29 September 2017
NeW wrinkles for an old domain
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PubMed Central
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29 September 2017
A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
1 reference
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PubMed Central
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29 September 2017
Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene
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PubMed Central
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29 September 2017
Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation
1 reference
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PubMed Central
reference URL
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27 November 2018
p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294
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27 November 2018
MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314294
retrieved
27 November 2018
Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15820682
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15820682
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ultrastructural analysis of bone nodules formed in vitro by isolated fetal rat calvaria cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15820682
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/15820682
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CELL.2005.01.035
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2064640
OpenCitations bibliographic resource ID
2064640
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2064640
PMCID
3314294
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2064640
PubMed ID
15820682
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2064640
ResearchGate publication ID
7915462
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