(Q28546932)

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NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer Cells

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NSC666715 and Its Analogs Inhibit Strand-Displacement Activity of DNA Polymerase β and Potentiate Temozolomide-Induced DNA Damage, Senescence and Apoptosis in Colorectal Cancer Cells (English)

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colorectal cancer

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colorectal carcinoma

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author name string

Aruna S Jaiswal

1

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Harekrushna Panda

2

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Brian K Law

3

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Jay Sharma

4

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Jitesh Jani

5

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Robert Hromas

6

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Satya Narayan

7

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publication date

2015

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10

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5

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e0123808

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Creative Commons Attribution 4.0 International

1 May 2015

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April 2022 Public Data File from Crossref

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4416822/fullTextXML

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Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Cellular senescence in cancer and aging

1 reference

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MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

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1 reference

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Food and Drug Administration Drug approval summary: temozolomide plus radiation therapy for the treatment of newly diagnosed glioblastoma multiforme

1 reference

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1 reference

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Human cell senescence as a DNA damage response.

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1 reference

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1 reference

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1 reference

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FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

1 reference

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1 reference

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1 reference

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NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA.

1 reference

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DNA damage tolerance, mismatch repair and genome instability

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25933036

12 December 2020

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inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0123808

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2015PLoSO..1023808J

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