(Q28581058)

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Inhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cells

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PubMed publication ID

31 January 2017

Inhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cells (English)

1 reference

PubMed publication ID

31 January 2017

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4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24084215%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Chrystelle V Garat

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24084215%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Joseph T Crossno

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24084215%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Timothy M Sullivan

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24084215%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Dwight J Klemm

5

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31 May 2020

publication date

1 December 2013

1 reference

PubMed publication ID

31 January 2017

Journal of Cardiovascular Pharmacology

2 references

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31 January 2017

Europe PubMed Central

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31 May 2020

62

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31 January 2017

Europe PubMed Central

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31 May 2020

6

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24084215%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

539-548

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24084215%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Molecular pathogenesis of pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

17 March 2017

PI3K/AKT/mTOR Pathway in Angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

17 March 2017

Role of p53 up-regulated modulator of apoptosis and phosphorylated Akt in melanoma cell growth, apoptosis, and patient survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

17 March 2017

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

17 March 2017

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

17 March 2017

Chronic hypoxia causes angiogenesis in addition to remodelling in the adult rat pulmonary circulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

17 March 2017

Signal transduction via platelet-derived growth factor receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

17 March 2017

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

17 March 2017

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

17 March 2017

CREB is a novel nuclear target of PTEN phosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

RACK1 regulates VEGF/Flt1-mediated cell migration via activation of a PI3K/Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Effects of HIV Protease Inhibitors on Progression of Monocrotaline- and Hypoxia-Induced Pulmonary Hypertension in Rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Insulin-like growth factor-1 induces phosphorylation of PI3K-Akt/PKB to potentiate proliferation of smooth muscle cells in human saphenous vein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Endothelin-1 signalling in vascular smooth muscle: pathways controlling cellular functions associated with atherosclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Angiotensin II stimulates phosphorylation of an ectodomain-truncated platelet-derived growth factor receptor-beta and its binding to class IA PI3K in vascular smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

PPARgamma and atherosclerosis: effects on cell growth and movement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Molecular mechanisms in intimal hyperplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Crosstalk between protein kinase A and growth factor receptor signaling pathways in arterial smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Endothelial cell responses to hypoxic stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

The mitogen-activated protein kinase pathway can mediate growth inhibition and proliferation in smooth muscle cells. Dependence on the availability of downstream targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

29 September 2017

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

3 June 2018

Platelet-derived growth factor BB induces nuclear export and proteasomal degradation of CREB via phosphatidylinositol 3-kinase/Akt signaling in pulmonary artery smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

3 June 2018

Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

3 June 2018

Characterization of fibroblast mitogens and chemoattractants produced by endothelial cells exposed to hypoxia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

3 June 2018

Immediate-early gene expression in response to hypertrophic and proliferative stimuli in pulmonary arterial smooth muscle cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

3 June 2018

Reduction of reactive oxygen species prevents hypoxia-induced CREB depletion in pulmonary artery smooth muscle cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

27 November 2018

Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

27 November 2018

Phosphatidylinositide 3-kinase is important in late-stage fibroblast growth factor-1-mediated angiogenesis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

27 November 2018

Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

27 November 2018

Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

27 November 2018

Different growth properties of neointimal and medial smooth muscle cells in response to growth factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

27 November 2018

Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

27 November 2018

NIP-121 is more effective than nifedipine in acutely reversing chronic pulmonary hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4143163

27 November 2018

Vascular remodeling and growth factor gene expression in the rat lung during hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24084215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/24084215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24084215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Cilazapril, a Novel Angiotensin Converting Enzyme Inhibitor, on the Structure of Pulmonary Arteries of Rats Exposed to Chronic Hypoxia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24084215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Angiotensin II activates phosphatidylinositol 3-kinase in vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24084215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration

1 reference

https://pubmed.ncbi.nlm.nih.gov/24084215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1097/FJC.0000000000000014

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24084215%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24084215%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

2 references

PubMed publication ID

31 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24084215%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

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