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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
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scholarly article
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stated in
PubMed
PubMed ID
16308421
retrieved
31 January 2017
title
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
(English)
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stated in
PubMed
PubMed ID
16308421
retrieved
31 January 2017
main subject
Stk11
0 references
glucose
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Protein kinase, AMP-activated, alpha 1 catalytic subunit
1 reference
stated in
GOA release 2020-03-11
Serine/threonine kinase 11
1 reference
stated in
GOA release 2020-03-11
Protein kinase, AMP-activated, alpha 2 catalytic subunit
1 reference
stated in
GOA release 2020-03-11
CREB regulated transcription coactivator 2
1 reference
stated in
GOA release 2020-03-11
metformin
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based on heuristic
inferred from title
author
Nabeel Bardeesy
series ordinal
5
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Ronald A. DePinho
series ordinal
6
object named as
Ronald A. Depinho
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PubMed
PubMed ID
16308421
retrieved
31 January 2017
Lewis C. Cantley
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8
object named as
Lewis C. Cantley
1 reference
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PubMed
PubMed ID
16308421
retrieved
31 January 2017
author name string
Reuben J. Shaw
series ordinal
1
1 reference
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PubMed
PubMed ID
16308421
retrieved
31 January 2017
Katja A. Lamia
series ordinal
2
1 reference
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PubMed
PubMed ID
16308421
retrieved
31 January 2017
Debbie Vasquez
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3
1 reference
stated in
PubMed
PubMed ID
16308421
retrieved
31 January 2017
Seung-Hoi Koo
series ordinal
4
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PubMed
PubMed ID
16308421
retrieved
31 January 2017
Marc Montminy
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7
1 reference
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PubMed
PubMed ID
16308421
retrieved
31 January 2017
language of work or name
English
0 references
publication date
9 December 2005
1 reference
stated in
PubMed
PubMed ID
16308421
retrieved
31 January 2017
published in
Science
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stated in
PubMed
PubMed ID
16308421
retrieved
31 January 2017
volume
310
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stated in
PubMed
PubMed ID
16308421
retrieved
31 January 2017
page(s)
1642–1646
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stated in
PubMed
PubMed ID
16308421
retrieved
31 January 2017
issue
5754
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PubMed
PubMed ID
16308421
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31 January 2017
on focus list of Wikimedia project
ScienceSource
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cites work
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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17 March 2017
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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17 March 2017
Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation
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PubMed Central
reference URL
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17 March 2017
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector
1 reference
stated in
PubMed Central
reference URL
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The LKB1 tumor suppressor negatively regulates mTOR signaling
1 reference
stated in
PubMed Central
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AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
1 reference
stated in
PubMed Central
reference URL
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17 March 2017
C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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17 March 2017
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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17 March 2017
AMP-activated protein kinase plays a role in the control of food intake
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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TSC2 mediates cellular energy response to control cell growth and survival
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PubMed Central
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17 March 2017
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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17 March 2017
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
1 reference
stated in
PubMed Central
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17 March 2017
Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
17 March 2017
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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17 March 2017
Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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17 March 2017
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
17 March 2017
Role of AMP-activated protein kinase in mechanism of metformin action
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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The blooming of the French lilac
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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
1 reference
stated in
PubMed Central
reference URL
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EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts
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Metabolic control through the PGC-1 family of transcription coactivators
1 reference
stated in
PubMed Central
reference URL
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7 April 2017
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
1 reference
stated in
PubMed Central
reference URL
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1 reference
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7 April 2017
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
1 reference
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PubMed Central
reference URL
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CREB: the unindicted cancer co-conspirator
1 reference
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PubMed Central
reference URL
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29 September 2017
Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.
1 reference
stated in
PubMed Central
reference URL
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29 September 2017
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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29 September 2017
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
29 September 2017
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
29 September 2017
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
29 September 2017
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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29 September 2017
Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
29 September 2017
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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29 September 2017
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
29 September 2017
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
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29 September 2017
Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
3 June 2018
Evidence for 5' AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
3 June 2018
Foxa2 integrates the transcriptional response of the hepatocyte to fasting.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
27 November 2018
Activating AMP-activated protein kinase without AMP.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
27 November 2018
Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
27 November 2018
Snf1 kinase complexes with different beta subunits display stress-dependent preferences for the three Snf1-activating kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
27 November 2018
Long-term AICAR administration and exercise prevents diabetes in ZDF rats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
27 November 2018
Metformin prevents the development of acute lipid-induced insulin resistance in the rat through altered hepatic signaling mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
27 November 2018
PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
27 November 2018
Regulation of fasted blood glucose by resistin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
27 November 2018
The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3074427
retrieved
27 November 2018
Identifiers
DOI
10.1126/SCIENCE.1120781
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1622673
ADS bibcode
2005Sci...310.1642S
0 references
OpenCitations bibliographic resource ID
1622673
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1622673
PMCID
3074427
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1622673
PubMed ID
16308421
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1622673
ResearchGate publication ID
7461327
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