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Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation
scientific journal article
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
title
Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation
(English)
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
main subject
haploinsufficiency
0 references
astrocyte
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Neurofibromin 1
1 reference
stated in
GOA release 2020-03-11
author name string
D. H. Gutmann
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
A. Loehr
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
Y. Zhang
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
J. Kim
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
M. Henkemeyer
series ordinal
5
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
A. Cashen
series ordinal
6
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
language of work or name
English
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publication date
5 August 1999
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
published in
Oncogene
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
volume
18
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stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
page(s)
4450–4459
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stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
issue
31
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
cites work
Neurofibromatosis and cancer.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulators and Effectors of ras Proteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and characterization of the neurofibromatosis type 1 protein product
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased expression of the neurofibromatosis 1 (NF1) gene product, neurofibromin, in astrocytes in response to cerebral ischemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proliferation of human malignant astrocytomas is dependent on Ras activation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the neurofibromatosis type 1 gene product
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Precocious puberty in children with neurofibromatosis type 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-D-aspartate neurotoxicity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the neurofibromatosis 1 (NF1) gene in reactive astrocytes in vitro
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of neurofibromin, the neurofibromatosis 1 gene product: studies in human neuroblastoma cells and rat brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The proliferative response of astrocytes to injury in neonatal rat brain. A combined immunocytochemical and autoradiographic study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation and cancer: statistical study of retinoblastoma
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Optic gliomas in children with neurofibromatosis type 1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 Optic Pathway Glioma Task Force.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Brainstem tumors in patients with neurofibromatosis type 1: a distinct clinical entity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Neurofibromin is enriched in the endoplasmic reticulum of CNS neurons.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the neurofibromatosis I gene product, neurofibromin, in blood vessel endothelial cells and smooth muscle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the neurofibromatosis 1 (NF1) gene during growth arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The management of brainstem gliomas in patients with neurofibromatosis 1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Astroglial proliferation and phenotype are modulated by neuronal plasma membrane.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
C17, a retrovirally immortalized neuronal cell line, inhibits the proliferation of astrocytes and astrocytoma cells by a contact-mediated mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The neurofibromatosis type 1 gene encodes a protein related to GAP
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.ONC.1202829
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.ONC.1202829
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
Dimensions Publication ID
1038208030
0 references
PubMed ID
10442636
1 reference
stated in
PubMed
PubMed ID
10442636
retrieved
31 January 2017
ResearchGate publication ID
12856453
0 references
Springer Nature article ID
10.1038/sj.onc.1202829
0 references
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