(Q28910209)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

title

Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1 (English)

2 references

7 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

main subject

prion protein family

0 references

transmembrane protein

0 references

Major prion protein

1 reference

LDL receptor related protein 1

1 reference

1 reference

FYN proto-oncogene, Src family tyrosine kinase

1 reference

positive regulation of protein localization to plasma membrane

1 reference

Prion protein

1 reference

1 reference

0 references

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

author name string

Jo V Rushworth

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Heledd H Griffiths

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Nicole T Watt

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

language of work or name

English

0 references

publication date

5 February 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

23 February 2020

published in

2 references

7 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

volume

288

2 references

7 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

page(s)

8935-8951

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

issue

13

2 references

7 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

23 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3610967/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier

16 March 2017

1 reference

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Alzheimer's disease brain-derived amyloid-β-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein

16 March 2017

1 reference

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Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers

16 March 2017

1 reference

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

16 March 2017

1 reference

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16 March 2017

2 references

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16 March 2017

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A specific amyloid-beta protein assembly in the brain impairs memory

16 March 2017

1 reference

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Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

The low-density lipoprotein receptor gene family: a cellular Swiss army knife?

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

16 March 2017

1 reference

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16 March 2017

1 reference

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Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

16 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

A beta oligomers - a decade of discovery

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Memory impairment in transgenic Alzheimer mice requires cellular prion protein

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Prion protein facilitates uptake of zinc into neuronal cells

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Amyloid-β-induced synapse damage is mediated via cross-linkage of cellular prion proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

The role of lipid rafts in prion protein biology

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

The prion protein as a receptor for amyloid-beta.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Low-density lipoprotein receptor-related protein 1 (LRP1) mediates neuronal Abeta42 uptake and lysosomal trafficking

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Prion protein and Abeta-related synaptic toxicity impairment

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Resveratrol selectively remodels soluble oligomers and fibrils of amyloid Abeta into off-pathway conformers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Alzheimer's disease: strategies for disease modification

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Prion protein and Alzheimer disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Cytoplasmic prion protein induces forebrain neurotoxicity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Structural classification of toxic amyloid oligomers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Oligomer-specific Abeta toxicity in cell models is mediated by selective uptake

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Endocytosis of prion protein is required for ERK1/2 signaling induced by stress-inducible protein 1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Protective effect of prion protein via the N-terminal region in mediating a protective effect on paraquat-induced oxidative injury in neuronal cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Conformation-dependent anti-amyloid oligomer antibodies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

The prion protein and lipid rafts

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Proteolytic mechanisms in amyloid-beta metabolism: therapeutic implications for Alzheimer's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Cellular prion protein neuroprotective function: implications in prion diseases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Signal transduction through prion protein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Cellular prion protein localization in rodent and primate brain.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Bicistronic vector for the creation of stable mammalian cell lines that predisposes all antibiotic-resistant cells to express recombinant protein.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610967

Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region

3 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

Self-assembly of Abeta(1-42) into globular neurotoxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

The low-density lipoprotein receptor-related protein 1 (LRP1) mediates the endocytosis of the cellular prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

Differential expression of cellular prion protein in mouse brain as detected with multiple anti-PrP monoclonal antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

Alzheimer's disease: A prion protein connection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

Tethering the N-terminus of the prion protein compromises the cellular response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

Membrane-bound β-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.400358

Fyn-tau-amyloid: a toxic triad

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23386614

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23386614

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M112.400358

2 references

7 March 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23386614%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

2 references

7 March 2017