(Q29614242)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

30 April 2017

author name string

Bjornsti MA

series ordinal

1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

30 April 2017

Houghton PJ

series ordinal

2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

30 April 2017

language of work or name

1 reference

30 April 2017

publication date

May 2004

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

30 April 2017

published in

Nature Reviews Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

30 April 2017

volume

4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

30 April 2017

page(s)

335-48

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

30 April 2017

issue

5

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

30 April 2017

cites work

1 reference

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

31 March 2020

1 reference

Rapamune® (RAPA, rapamycin, sirolimus): mechanism of action immunosuppressive effect results from blockade of signal transduction and inhibition of cell cycle progression

31 March 2020

1 reference

Rapamycin for immunosuppression in organ allografting.

31 March 2020

1 reference

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

31 March 2020

1 reference

New immunosuppressive drugs: an update

31 March 2020

1 reference

Rapamycin in transplantation: a review of the evidence

31 March 2020

1 reference

31 March 2020

1 reference

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

31 March 2020

1 reference

Regulation of translation initiation by FRAP/mTOR

31 March 2020

1 reference

Tor signalling in bugs, brain and brawn

31 March 2020

1 reference

Identification of TOR signaling complexes: more TORC for the cell growth engine

31 March 2020

1 reference

FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse

31 March 2020

1 reference

The TOR signaling cascade regulates gene expression in response to nutrients

31 March 2020

1 reference

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

31 March 2020

1 reference

Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae

31 March 2020

1 reference

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

31 March 2020

1 reference

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

31 March 2020

1 reference

Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control

31 March 2020

1 reference

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

31 March 2020

1 reference

Identification of a conserved motif required for mTOR signaling

31 March 2020

1 reference

TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function

31 March 2020

1 reference

BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells

31 March 2020

1 reference

The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways.

31 March 2020

1 reference

Myogenic differentiation is dependent on both the kinase function and the N-terminal sequence of mammalian target of rapamycin

31 March 2020

1 reference

The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism

31 March 2020

1 reference

The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation

31 March 2020

1 reference

Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation

31 March 2020

1 reference

Predominant nuclear localization of mammalian target of rapamycin in normal and malignant cells in culture

31 March 2020

1 reference

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling

31 March 2020

1 reference

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

31 March 2020

1 reference

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

31 March 2020

1 reference

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

31 March 2020

1 reference

Akt regulates growth by directly phosphorylating Tsc2

31 March 2020

1 reference

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

31 March 2020

1 reference

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

31 March 2020

1 reference

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

31 March 2020

1 reference

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

31 March 2020

1 reference

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

31 March 2020

1 reference

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.

31 March 2020

1 reference

Identification and characterization of the interaction between tuberin and 14-3-3zeta

31 March 2020

1 reference

Regulation of TSC2 by 14-3-3 binding

31 March 2020

1 reference

14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin

31 March 2020

1 reference

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

31 March 2020

1 reference

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent

31 March 2020

1 reference

TSC2 mediates cellular energy response to control cell growth and survival

31 March 2020

1 reference

Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity

31 March 2020

1 reference

The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis

31 March 2020

1 reference

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

31 March 2020

1 reference

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

31 March 2020

1 reference

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

31 March 2020

1 reference

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

31 March 2020

1 reference

Rheb promotes cell growth as a component of the insulin/TOR signalling network

31 March 2020

1 reference

Role of S6 phosphorylation and S6 kinase in cell growth

31 March 2020

1 reference

4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle

31 March 2020

1 reference

Phosphorylation and activation of p70s6k by PDK1

31 March 2020

1 reference

The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

31 March 2020

1 reference

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

31 March 2020

1 reference

Mutational analysis of ribosomal S6 kinase 2 shows differential regulation of its kinase activity from that of ribosomal S6 kinase 1

31 March 2020

1 reference

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

31 March 2020

1 reference

Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast

31 March 2020

1 reference

Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast

31 March 2020

1 reference

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

31 March 2020

1 reference

B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

31 March 2020

1 reference

Alpha 4 associates with protein phosphatases 2A, 4, and 6

31 March 2020

1 reference

Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein

31 March 2020

1 reference

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

31 March 2020

1 reference

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

31 March 2020

1 reference

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

31 March 2020

1 reference

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

31 March 2020

1 reference

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

31 March 2020

1 reference

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice.

31 March 2020

1 reference

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

31 March 2020

1 reference

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

31 March 2020

1 reference

Regulation of eIF-4E BP1 phosphorylation by mTOR.

31 March 2020

1 reference

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

31 March 2020

1 reference

Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.

31 March 2020

1 reference

PHAS-I as a link between mitogen-activated protein kinase and translation initiation

31 March 2020

1 reference

Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies

31 March 2020

1 reference

Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

31 March 2020

1 reference

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

31 March 2020

1 reference

Rapamycin inhibition of the G1 to S transition is mediated by effects on cyclin D1 mRNA and protein stability

31 March 2020

1 reference

Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

31 March 2020

1 reference

Drosophila S6 kinase: a regulator of cell size.

31 March 2020

1 reference

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

31 March 2020

1 reference

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

31 March 2020

1 reference

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

31 March 2020

1 reference

4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin

31 March 2020

1 reference

Expression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cells

31 March 2020

1 reference

Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells

31 March 2020

1 reference

Interleukin-2-mediated elimination of the p27Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin

31 March 2020

1 reference

Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

31 March 2020

1 reference

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

31 March 2020

1 reference

Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells

31 March 2020

1 reference

Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression

31 March 2020

1 reference

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

31 March 2020

1 reference

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

1 reference

Targeting the PI3K-Akt pathway in human cancer: rationale and promise

31 March 2020

1 reference

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

31 March 2020

1 reference

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

31 March 2020

1 reference

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

31 March 2020

1 reference

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

31 March 2020

1 reference

Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers

31 March 2020

1 reference

mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer

31 March 2020

1 reference

Molecular genetic advances in tuberous sclerosis

31 March 2020

1 reference

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

31 March 2020

1 reference

Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway

31 March 2020

1 reference

HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

31 March 2020

1 reference

BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

31 March 2020

1 reference

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

31 March 2020

1 reference

Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)-dependent signaling

31 March 2020

1 reference

A novel approach for expression cloning of small GTPases: identification, tissue distribution and chromosome mapping of the human homolog of rheb

31 March 2020

1 reference

Constitutive activation of p70S6k in cancer cells

31 March 2020

1 reference

Dysregulation of phosphatidylinositol 3-kinase and downstream effectors in human breast cancer

31 March 2020

1 reference

Coexpression of hepatocyte growth factor-Met: an early step in ovarian carcinogenesis?

31 March 2020

1 reference

The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts

31 March 2020

1 reference

Ras mediates translation initiation factor 4E-induced malignant transformation

31 March 2020

1 reference

Translational regulation of ribonucleotide reductase by eukaryotic initiation factor 4E links protein synthesis to the control of DNA replication

31 March 2020

1 reference

Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase

31 March 2020

1 reference

The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth

31 March 2020

1 reference

Upregulated expression of the genes encoding translation initiation factors eIF-4E and eIF-2alpha in transformed cells

31 March 2020

1 reference

Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines

31 March 2020

1 reference

Reduction of translation initiation factor 4E decreases the malignancy of ras -transformed cloned rat embryo fibroblasts

31 March 2020

1 reference

Decreasing the level of translation initiation factor 4E with antisense RNA causes reversal of ras-mediated transformation and tumorigenesis of cloned rat embryo fibroblasts.

31 March 2020

1 reference

Antisense RNA to eIF4E suppresses oncogenic properties of a head and neck squamous cell carcinoma cell line.

31 March 2020

1 reference

Expression of eukaryotic translation initiation factors 4E and 2alpha correlates with the progression of thyroid carcinoma

31 March 2020

1 reference

Expression of eukaryotic translation initiation factors 4E and 2alpha is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung

31 March 2020

1 reference

Expression of the eukaryotic translation initiation factors 4E and 2alpha in non-Hodgkin's lymphomas

31 March 2020

1 reference

Overexpression of the eukaryotic translation initiation factor 4G (eIF4G-1) in squamous cell lung carcinoma.

31 March 2020

1 reference

4E binding protein 1 expression is inversely correlated to the progression of gastrointestinal cancers

31 March 2020

1 reference

Involvement of the Akt/mTOR pathway on EGF-induced cell transformation

31 March 2020

1 reference

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

31 March 2020

1 reference

AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression

31 March 2020

1 reference

TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

31 March 2020

1 reference

Insulin-like growth factor-I inhibits transcriptional responses of transforming growth factor-beta by phosphatidylinositol 3-kinase/Akt-dependent suppression of the activation of Smad3 but not Smad2.

31 March 2020

1 reference

New antitumor substances of natural origin

31 March 2020

1 reference

Human brain tumor xenografts in nude mice as a chemotherapy model.

31 March 2020

1 reference

Activity of rapamycin (AY-22,989) against transplanted tumors

31 March 2020

1 reference

Clinical development of mammalian target of rapamycin inhibitors

31 March 2020

1 reference

Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma

31 March 2020

1 reference

Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.

31 March 2020

1 reference

Rapamycins: mechanism of action and cellular resistance

31 March 2020

1 reference

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

31 March 2020

1 reference

The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma

31 March 2020

1 reference

The expression of proto-oncogene eIF4E in laryngeal squamous cell carcinoma.

31 March 2020

1 reference

Molecular analysis of surgical margins in head and neck squamous cell carcinoma patients

31 March 2020

1 reference

Progression of eIF4e gene amplification and overexpression in benign and malignant tumors of the head and neck.

31 March 2020

1 reference

Pattern of amplification and overexpression of the eukaryotic initiation factor 4E gene in solid tumor

31 March 2020

1 reference

The proto-oncogene/translation factor eIF4E: A survey of its expression in breast carcinomas

31 March 2020

1 reference

Prospective study of eukaryotic initiation factor 4E protein elevation and breast cancer outcome

31 March 2020

1 reference

Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E.

31 March 2020

1 reference

Elevated expression of eIF4E and FGF-2 isoforms during vascularization of breast carcinomas

31 March 2020

1 reference

Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

31 March 2020

1 reference

Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression

31 March 2020

1 reference

Phospholipase D confers rapamycin resistance in human breast cancer cells

31 March 2020

1 reference

Ca(2+)-independent protein kinase C activity is required for alpha1-adrenergic-receptor-mediated regulation of ribosomal protein S6 kinases in adult cardiomyocytes

31 March 2020

1 reference

Mammalian TOR: a homeostatic ATP sensor

31 March 2020

1 reference

Amino acids as regulators and components of nonproteinogenic pathways

31 March 2020

1 reference

Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells

31 March 2020

1 reference

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

31 March 2020

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

374656

1046070024

0 references

374656

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=15122205

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017