Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q29617706)
Watch
English
Chk1 and Chk2 kinases in checkpoint control and cancer
scientific article (publication date: May 2003)
In more languages
edit
Statements
instance of
scholarly article
0 references
review article
1 reference
stated in
Europe PubMed Central
title
Chk1 and Chk2 kinases in checkpoint control and cancer
(English)
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359
retrieved
30 April 2017
author name string
Bartek J
series ordinal
1
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359
retrieved
30 April 2017
Lukas J
series ordinal
2
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359
retrieved
30 April 2017
language of work or name
English
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359
retrieved
30 April 2017
publication date
May 2003
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359
retrieved
30 April 2017
published in
Cancer Cell
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359
retrieved
30 April 2017
volume
3
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359
retrieved
30 April 2017
page(s)
421-9
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359
retrieved
30 April 2017
issue
5
1 reference
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359
retrieved
30 April 2017
cites work
Cell cycle checkpoint signaling through the ATM and ATR kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation analysis of the CHK2 gene in families with hereditary breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian G1- and S-phase checkpoints in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CHK2 kinase--a busy messenger.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk2 tumour suppressor protein in human spermatogenesis and testicular germ-cell tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATR and ATRIP: partners in checkpoint signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Therapeutic exploitation of checkpoint defects in cancer cells lacking p53 function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA-dependent acetylation of p53 by the transcription coactivator p300.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDC1 is required for the intra-S-phase DNA damage checkpoint
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of Chk2 in primary hematopoietic neoplasms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genome maintenance mechanisms for preventing cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation analysis of the CHK2 gene in breast carcinoma and other cancers
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The many substrates and functions of ATM
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA double-strand breaks: signaling, repair and the cancer connection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapid destruction of human Cdc25A in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of CHK2 in vulval neoplasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular mechanism of the interaction between MDM2 and p53.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In search of the tumour-suppressor functions of BRCA1 and BRCA2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATM and related protein kinases: safeguarding genome integrity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk2 activates E2F-1 in response to DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDC1 is a mediator of the mammalian DNA damage checkpoint
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Concomitant inactivation of p53 and Chk2 in breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of the CHK2 gene in lymphoid malignancies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomas
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
53BP1, a mediator of the DNA damage checkpoint
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Characterization of tumor-associated Chk2 mutations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk2 activation and phosphorylation-dependent oligomerization
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The DNA damage response: putting checkpoints in perspective
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1535-6108%2803%2900110-7
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1535-6108(03)00110-7
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3282984
OpenCitations bibliographic resource ID
3282984
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3282984
PubMed ID
12781359
2 references
stated in
PubMed
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12781359
retrieved
30 April 2017
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3282984
ResearchGate publication ID
10730834
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit