(Q29793457)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

Interaction and regulation of subcellular localization of CED-4 by CED-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

Interaction between the C. elegans cell-death regulators CED-9 and CED-4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

protein homodimerization activity

IPI

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

protein heterodimerization activity

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

A complex II defect affects mitochondrial structure, leading to ced-3- and ced-4-dependent apoptosis and aging.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

mitochondrial outer membrane

IDA

1 reference

31 January 2018

Regulation of apoptosis by C. elegans CED-9 in the absence of the C-terminal transmembrane domain

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41958&geneProductId=UniProtKB:P41958

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 reference

1 January 2018

Interaction and regulation of subcellular localization of CED-4 by CED-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

IDA

mitochondrial membranes

1 reference

1 January 2018

1 reference

1 January 2018

The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

perinuclear region of cytoplasm

1 reference

1 January 2018

Interaction and regulation of subcellular localization of CED-4 by CED-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 reference

1 January 2018

The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

autophagy of mitochondrion

IDA

biological process

1 reference

1 January 2018

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

3 references

1 January 2018

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

intrinsic apoptotic signaling pathway in response to DNA damage

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

positive regulation of mitochondrial fusion

1 reference

1 January 2018

CED-9 and mitochondrial homeostasis in C. elegans muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

actin filament depolymerization

1 reference

1 January 2018

The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

positive regulation of embryonic development

regulation of apoptotic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

negative regulation of apoptotic process

negative regulation of programmed cell death

1 reference

1 January 2018

Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

positive regulation of GTPase activity

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

regulation of synapse organization

1 reference

1 January 2018

The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

positive regulation of brood size

1 reference

1 January 2018

Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

extrinsic apoptotic signaling pathway in absence of ligand

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

positive regulation of oviposition

apoptotic process involved in development

1 reference

1 January 2018

Programmed elimination of cells by caspase-independent cell extrusion in C. elegans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

positive regulation of fertilization

1 reference

1 January 2018

Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

positive regulation of synapse pruning

negative regulation of apoptotic process

3 references

1 January 2018

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

negative regulation of intrinsic apoptotic signaling pathway

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41958

Apoptosis regulator, Bcl-2, BH1 motif, conserved site

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41958

Apoptosis regulator, Bcl-2 protein, BH4

1 reference

stated in

InterPro Release 71.0