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Licorne Dmel_CG12244
Protein found in Drosophila melanogaster
p38 MAPK
CG12244 gene product from transcript CG12244-RA
lic-PA
Mkk3
CG12244-PA
lic
MAP kinase kinase 3
MEK-kinase 3
licorne
drosophila MAP kinase kinase 3
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
O62602
part of
Protein kinase-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O62602
Protein kinase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Serine/threonine-protein kinase, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
O62602
encoded by
lic
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
O62602
molecular function
protein kinase activity
determination method
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IEA
retrieved
8 April 2019
stated in
The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IDA
protein serine/threonine kinase activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IBA
protein kinase C activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O62602
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IEA
MAP kinase kinase activity
determination method
IDA
TAS
3 references
retrieved
24 April 2018
stated in
p38 MAPK signalling cascades: ancient roles and new functions
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O62602&geneProductId=UniProtKB:O62602
determination method
TAS
retrieved
24 April 2018
stated in
A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O62602&geneProductId=UniProtKB:O62602
determination method
IDA
retrieved
24 April 2018
stated in
The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O62602&geneProductId=UniProtKB:O62602
determination method
IDA
ATP binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IEA
kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O62602
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IEA
transferase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O62602
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IEA
mitogen-activated protein kinase kinase kinase binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IPI
MAP kinase kinase activity
determination method
IBA
IDA
TAS
4 references
retrieved
8 April 2019
stated in
p38 MAPK signalling cascades: ancient roles and new functions
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
TAS
retrieved
8 April 2019
stated in
The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IDA
retrieved
8 April 2019
stated in
A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IBA
cell component
cytoplasm
determination method
IBA
ISS
2 references
retrieved
8 April 2019
stated in
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
ISS
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IBA
biological process
MAPK cascade
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IDA
positive regulation of protein phosphorylation
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IGI
mucosal immune response
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IMP
protein phosphorylation
determination method
IEA
NAS
2 references
retrieved
8 April 2019
stated in
Protein kinases and phosphatases in the Drosophila genome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IEA
oocyte axis specification
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IMP
oocyte anterior/posterior axis specification
determination method
NAS
1 reference
retrieved
8 April 2019
stated in
p38 MAPK signalling cascades: ancient roles and new functions
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
NAS
regulation of mitotic cell cycle
determination method
IBA
1 reference
retrieved
24 April 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O62602&geneProductId=UniProtKB:O62602
determination method
IBA
phosphorylation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O62602
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IEA
stress-activated protein kinase signaling cascade
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IBA
positive regulation of multicellular organism growth
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IMP
regulation of apoptotic process
determination method
IBA
1 reference
retrieved
24 April 2018
stated in
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O62602&geneProductId=UniProtKB:O62602
determination method
IBA
positive regulation of cell size
determination method
IGI
IMP
2 references
retrieved
8 April 2019
stated in
A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IMP
retrieved
8 April 2019
stated in
A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IGI
regulation of adult chitin-containing cuticle pigmentation
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IGI
negative regulation of canonical Wnt signaling pathway
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IMP
p38MAPK cascade
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IMP
signal transduction
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IBA
activation of protein kinase activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O62602
determination method
IBA
has part(s)
serine/threonine-protein kinase, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O62602
protein kinase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/O62602
Identifiers
RefSeq protein ID
NP_477162
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
32257
UniProt protein ID
O62602
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
O62602
Ensembl protein ID
FBpp0073551
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0073551
Sitelinks
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Multilingual sites
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