(Q29811609)

English

Clock Dmel_CG7391

Protein found in Drosophila melanogaster

Clk-PA
Clk-PH
CG7391-PD
Clk-PG
Clk
Clk-PF
CG7391-PH
CG7391-PG
CG7391 gene product from transcript CG7391-RA
dClock
CLOCK
CG7391-PF
CG7391-PA
Clk-PD

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Nuclear translocator

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O61735

PAS domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O61735

Helix-loop-helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O61735

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PAC motif domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PAS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

determination method

4 references

8 April 2019

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

PER-dependent rhythms in CLK phosphorylation and E-box binding regulate circadian transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

chromatin binding

determination method

1 reference

8 April 2019

A Screening of UNF Targets Identifies Rnb, a Novel Regulator of Drosophila Circadian Rhythms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

DNA-binding transcription factor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

protein binding

determination method

4 references

8 April 2019

The CK2 kinase stabilizes CLOCK and represses its activity in the Drosophila circadian oscillator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Cytoplasmic interaction with CYCLE promotes the post-translational processing of the circadian CLOCK protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

transcription factor binding

determination method

1 reference

8 April 2019

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

protein heterodimerization activity

determination method

3 references

8 April 2019

From biological clock to biological rhythms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Cytoplasmic interaction with CYCLE promotes the post-translational processing of the circadian CLOCK protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

protein dimerization activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

transcription regulator complex

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

CLOCK-BMAL transcription complex

determination method

1 reference

8 April 2019

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

biological process

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

From biological clock to biological rhythms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

circadian regulation of heart rate

determination method

1 reference

8 April 2019

Time-restricted feeding attenuates age-related cardiac decline in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

transcription, DNA-templated

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O61735&geneProductId=UniProtKB:O61735

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

rhythmic behavior

determination method

1 reference

8 April 2019

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

circadian rhythm

determination method

12 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

From biological clock to biological rhythms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Central and peripheral circadian oscillator mechanisms in flies and mammals.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Circadian rhythms from flies to human

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

A rhythmic Ror.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Drosophila: genetics meets behaviour.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Drosophila clock can generate ectopic circadian clocks.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

response to temperature stimulus

determination method

1 reference

27 February 2018

Phosphorylation of a central clock transcription factor is required for thermal but not photic entrainment.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O61735&geneProductId=UniProtKB:O61735

determination method

entrainment of circadian clock

determination method

1 reference

8 April 2019

Phosphorylation of a central clock transcription factor is required for thermal but not photic entrainment.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

circadian regulation of gene expression

determination method

3 references

8 April 2019

Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABAA Receptor.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

negative regulation of apoptotic process

determination method

1 reference

8 April 2019

Drosophila spaghetti and doubletime link the circadian clock and light to caspases, apoptosis and tauopathy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

regulation of circadian sleep/wake cycle, sleep

determination method

1 reference

8 April 2019

Stress response genes protect against lethal effects of sleep deprivation in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

locomotor rhythm

determination method

4 references

8 April 2019

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Drosophila: genetics meets behaviour.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Drosophila clock can generate ectopic circadian clocks.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

positive regulation of transcription, DNA-templated

determination method

4 references

8 April 2019

Central and peripheral circadian oscillator mechanisms in flies and mammals.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Circadian rhythms from flies to human

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

positive regulation of transcription by RNA polymerase II

determination method

4 references

8 April 2019

Genetic analysis of the circadian system in Drosophila melanogaster and mammals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

From biological clock to biological rhythms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABAA Receptor.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

8 April 2019

Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

rhythmic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

response to light stimulus

determination method

1 reference

8 April 2019

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O61735

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O61735

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O61735

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O61735

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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