(Q29812464)

Protein kinase-like domain superfamily

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Raf-like Ras-binding domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

protein kinase activity

1 reference

1 January 2018

MAP kinase kinase kinase activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

3 references

1 January 2018

Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 January 2018

The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 January 2018

CNK, a RAF-binding multidomain protein required for RAS signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

mitogen-activated protein kinase kinase binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

intracellular anatomical structure

cell component

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

instar larval development

1 reference

1 January 2018

Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

protein phosphorylation

1 reference

1 January 2018

epidermal growth factor receptor signaling pathway

1 reference

1 January 2018

Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

Somatic control over the germline stem cell lineage during Drosophila spermatogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

border follicle cell migration

1 reference

1 January 2018

Two distinct modes of guidance signalling during collective migration of border cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

Coactivation of STAT and Ras Is Required for Germ Cell Proliferation and Invasive Migration in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

primary branching, open tracheal system

1 reference

1 January 2018

Branching morphogenesis of the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs.

TAS

wing disc morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

imaginal disc-derived wing morphogenesis

1 reference

1 January 2018

Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

The insect neuropeptide PTTH activates receptor tyrosine kinase torso to initiate metamorphosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

dorsal/ventral axis specification, ovarian follicular epithelium

TAS

1 reference

1 January 2018

Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

positive regulation of cell population proliferation

1 reference

1 January 2018

EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

Characterization of maternal and zygotic D-raf proteins: dominant negative effects on Torso signal transduction.

torso signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

imaginal disc-derived wing vein morphogenesis

1 reference

1 January 2018

The Drosophila Arf GEF Steppke controls MAPK activation in EGFR signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

cellular response to starvation

1 reference

1 January 2018

Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

negative regulation of macroautophagy

1 reference

1 January 2018

Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila melanogaster oogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

1 reference

1 January 2018

Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

regulation of cellular pH

TAS

1 reference

1 January 2018

Increased H⁺ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

wing and notum subfield formation

1 reference

1 January 2018

DER signaling restricts the boundaries of the wing field during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

intracellular signal transduction

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

regulation of multicellular organism growth

1 reference

1 January 2018

Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

hemocyte differentiation

photoreceptor cell development

1 reference

1 January 2018

The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

positive regulation of photoreceptor cell differentiation

1 reference

1 January 2018

Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

positive regulation of Ras protein signal transduction

1 reference

1 January 2018

A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

protein autophosphorylation

1 reference

1 January 2018

Biochemical analysis of torso and D-raf during Drosophila embryogenesis: implications for terminal signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

A protein network-guided screen for cell cycle regulators in Drosophila

IDA

regulation of cell cycle

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

positive regulation of ERK1 and ERK2 cascade

IDA

1 reference

1 January 2018

A functional screen reveals an extensive layer of transcriptional and splicing control underlying RAS/MAPK signaling in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

negative regulation of apoptotic signaling pathway

1 reference

1 January 2018

Ras promotes cell survival in Drosophila by downregulating hid expression.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P11346&geneProductId=UniProtKB:P11346

serine-threonine/tyrosine-protein kinase, catalytic domain

has part(s)

1 reference

Raf-like Ras-binding

1 reference

protein kinase domain

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

protein kinase, ATP binding site

1 reference

serine/threonine-protein kinase, active site

1 reference