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Aurora A Dmel_CG3068
Protein found in Drosophila melanogaster
aurA
aurora kinase
early-A
CG3068 gene product from transcript CG3068-RA
CG3068-PA
aurora-A
aurA-PA
fruhe2
A-type aurora kinase
Aurora-A kinase
aurora A
AuroraA
aurora A kinase
aurora
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9VGF9
part of
aurora kinase
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9VGF9
Protein kinase-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9VGF9
Protein kinase domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Protein kinase, ATP binding site, protein family
1 reference
based on heuristic
inferred from protein domain or family
Serine/threonine-protein kinase, active site, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9VGF9
encoded by
aurA
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9VGF9
molecular function
nucleotide binding
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9VGF9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IEA
protein kinase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IEA
protein serine/threonine kinase activity
determination method
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9VGF9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IEA
retrieved
8 April 2019
stated in
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IDA
protein serine/threonine/tyrosine kinase activity
determination method
IDA
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9VGF9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IEA
retrieved
8 April 2019
stated in
Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IDA
protein binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
Mitotic activation of the kinase Aurora-A requires its binding partner Bora
GOA
curator
UniProt
UniProt protein ID
Q9VGF9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IPI
ATP binding
determination method
IEA
2 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9VGF9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IEA
transferase activity
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9VGF9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IEA
histone serine kinase activity
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IBA
cell component
cytoplasm
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IDA
centrosome
determination method
IDA
NAS
2 references
retrieved
8 April 2019
stated in
Centrosomal TACCtics
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
NAS
retrieved
8 April 2019
stated in
Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IDA
spindle microtubule
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IBA
spindle pole centrosome
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IBA
chromosome passenger complex
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IBA
spindle midzone
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IBA
biological process
protein phosphorylation
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IEA
cell cycle
determination method
IEA
1 reference
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9VGF9&geneProductId=UniProtKB:Q9VGF9
determination method
IEA
mitotic spindle organization
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IBA
centrosome cycle
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
mitotic centrosome separation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
pole cell formation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Transport of germ plasm on astral microtubules directs germ cell development in Drosophila
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
peptidyl-serine phosphorylation
determination method
IDA
1 reference
retrieved
8 April 2019
stated in
Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IDA
regulation of cytokinesis
determination method
IBA
1 reference
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IBA
asymmetric protein localization involved in cell fate determination
determination method
IMP
3 references
retrieved
8 April 2019
stated in
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
retrieved
8 April 2019
stated in
Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
retrieved
8 April 2019
stated in
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
regulation of neurogenesis
determination method
IMP
2 references
retrieved
8 April 2019
stated in
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
retrieved
8 April 2019
stated in
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
establishment of spindle orientation
determination method
IMP
2 references
retrieved
8 April 2019
stated in
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
retrieved
8 April 2019
stated in
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
centrosome separation
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
symmetric cell division
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Aurora A triggers Lgl cortical release during symmetric division to control planar spindle orientation.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
regulation of protein localization to cell cortex
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9VGF9
determination method
IMP
has part(s)
serine/threonine-protein kinase, active site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9VGF9
protein kinase, ATP binding site
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9VGF9
protein kinase domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q9VGF9
Identifiers
RefSeq protein ID
NP_476749
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
41446
UniProt protein ID
Q9VGF9
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q9VGF9
Ensembl protein ID
FBpp0081957
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0081957
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