(Q29814574)

English

Hedgehog Dmel_CG4637

Protein found in Drosophila melanogaster

hh
PKC
hedgehog
CG4637-PB
CG4637 gene product from transcript CG4637-RB
moonrat
hh-PB
atypical
hedghog
bar-on-3
mirabile

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

Hedgehog signalling/DD-peptidase zinc-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02936

Hint domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02936

hedgehog protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02936

Hint domain N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hint domain C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hedgehog protein, Hint domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hedgehog, N-terminal signalling domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Drosophila melanogaster

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

patched binding

determination method

3 references

1 January 2018

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

smoothened binding

determination method

1 reference

8 April 2019

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

protein binding

determination method

4 references

8 April 2019

The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Genetic and biochemical definition of the Hedgehog receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Structure of a heparin-dependent complex of Hedgehog and Ihog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

morphogen activity

determination method

4 references

8 April 2019

The development of the Drosophila genital disc.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Cytoneme-mediated cell-cell contacts for Hedgehog reception.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

patched binding

determination method

4 references

8 April 2019

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The Drosophila hedgehog gene is expressed specifically in posterior compartment cells and is a target of engrailed regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

calcium ion binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

extracellular region

determination method

5 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

7 November 2018

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

7 November 2018

Genetic control of cell proliferation and differentiation in Drosophila spermatogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

7 November 2018

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

extracellular space

determination method

3 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

Quantitative analysis of Hedgehog gradient formation using an inducible expression system

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

determination method

1 reference

8 April 2019

Quantitative analysis of Hedgehog gradient formation using an inducible expression system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

plasma membrane

determination method

3 references

8 April 2019

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Quantitative analysis of Hedgehog gradient formation using an inducible expression system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

endocytic vesicle

determination method

1 reference

8 April 2019

Patched, the receptor of Hedgehog, is a lipoprotein receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

Cholesterol modification of hedgehog is required for trafficking and movement, revealing an asymmetric cellular response to hedgehog

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

extracellular space

determination method

5 references

1 January 2018

Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

Quantitative analysis of Hedgehog gradient formation using an inducible expression system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

extracellular region

determination method

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Genetic control of cell proliferation and differentiation in Drosophila spermatogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

extracellular space

determination method

6 references

8 April 2019

Secretion of the amino-terminal fragment of the hedgehog protein is necessary and sufficient for hedgehog signalling in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Quantitative analysis of Hedgehog gradient formation using an inducible expression system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

biological process

compound eye morphogenesis

determination method

1 reference

8 April 2019

Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

Bolwig's organ morphogenesis

determination method

1 reference

8 April 2019

Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

compound eye photoreceptor cell differentiation

determination method

1 reference

8 April 2019

Coming to our senses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

mucosal immune response

determination method

1 reference

8 April 2019

Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

24 April 2018

Generating patterns from fields of cells. Examples from Drosophila segmentation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

determination method

2 references

smoothened signaling pathway

determination method

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

Cholesterol metabolism and embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

positive regulation of hh target transcription factor activity

determination method

1 reference

24 April 2018

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

pole cell migration

determination method

1 reference

8 April 2019

HMGCoA reductase potentiates hedgehog signaling in Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

regulation of mitotic cell cycle

determination method

1 reference

8 April 2019

Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

segment polarity determination

determination method

6 references

24 April 2018

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

Generating patterns from fields of cells. Examples from Drosophila segmentation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

compartment pattern specification

determination method

1 reference

8 April 2019

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

ectoderm development

determination method

1 reference

8 April 2019

Genetics of heart development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

ventral midline development

determination method

1 reference

8 April 2019

Determination of cell fate along the anteroposterior axis of the Drosophila ventral midline.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

open tracheal system development

determination method

1 reference

24 April 2018

Branching morphogenesis of the Drosophila tracheal system.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

epithelial cell migration, open tracheal system

determination method

1 reference

8 April 2019

Hedgehog signaling patterns the tracheal branches.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

foregut morphogenesis

determination method

1 reference

8 April 2019

Developmental genetics of the Drosophila gut: specification of primordia, subdivision and overt-differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

imaginal disc growth

determination method

1 reference

8 April 2019

How are the sizes of cells, organs, and bodies controlled?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

progression of morphogenetic furrow involved in compound eye morphogenesis

determination method

4 references

8 April 2019

Patterning the neural retina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

wing disc proximal/distal pattern formation

determination method

1 reference

8 April 2019

Pattern formation in the Drosophila wing: The development of the veins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

imaginal disc-derived wing vein specification

determination method

1 reference

8 April 2019

Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

leg disc morphogenesis

determination method

1 reference

8 April 2019

The development of the Drosophila genital disc.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

analia development

determination method

1 reference

8 April 2019

The development of the Drosophila genital disc.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

mesoderm development

determination method

1 reference

8 April 2019

Genetics of heart development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

gonadal mesoderm development

determination method

1 reference

8 April 2019

Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

glial cell migration

determination method

1 reference

8 April 2019

Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

epidermis development

determination method

1 reference

8 April 2019

Tissue- and stage-specific modulation of Wingless signaling by the segment polarity gene lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

anterior/posterior axis specification, embryo

determination method

1 reference

8 April 2019

Drosophila development: novel signal elicits visceral response.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

anatomical structure morphogenesis

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

embryonic pattern specification

determination method

1 reference

8 April 2019

Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

morphogenesis of larval imaginal disc epithelium

determination method

1 reference

8 April 2019

Developmental analysis and squamous morphogenesis of the peripodial epithelium in Drosophila imaginal discs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

intein-mediated protein splicing

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

protein autoprocessing

determination method

3 references

8 April 2019

Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

anterior commissure morphogenesis

determination method

1 reference

8 April 2019

Determination of cell fate along the anteroposterior axis of the Drosophila ventral midline.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

ovarian follicle cell development

determination method

1 reference

24 April 2018

Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

ovarian follicle cell stalk formation

determination method

1 reference

8 April 2019

Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

negative regulation of protein ubiquitination

determination method

1 reference

8 April 2019

Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

labial disc development

determination method

1 reference

8 April 2019

Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

genital disc anterior/posterior pattern formation

determination method

1 reference

8 April 2019

Expression patterns of developmental genes reveal segment and parasegment organization of D. melanogaster genital discs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

cytoneme assembly

determination method

1 reference

8 April 2019

Cytonemes: cellular processes that project to the principal signaling center in Drosophila imaginal discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

germ cell attraction

determination method

1 reference

8 April 2019

Cell migration and programmed cell death of Drosophila germ cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

spiracle morphogenesis, open tracheal system

determination method

1 reference

8 April 2019

Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

anterior head segmentation

determination method

1 reference

8 April 2019

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

posterior head segmentation

determination method

1 reference

8 April 2019

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

trunk segmentation

determination method

1 reference

8 April 2019

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

germ-line stem cell division

determination method

1 reference

8 April 2019

The stem-cell niche theory: lessons from flies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

regulation of cell population proliferation

determination method

1 reference

8 April 2019

The development of the Drosophila genital disc.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

cell-cell signaling involved in cell fate commitment

determination method

1 reference

8 April 2019

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

R8 cell fate specification

determination method

1 reference

1 January 2018

R8 development in the Drosophila eye: a paradigm for neural selection and differentiation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

positive regulation of fibroblast growth factor receptor signaling pathway

determination method

1 reference

24 April 2018

Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

negative regulation of proteolysis

determination method

1 reference

24 April 2018

Costal 2 interactions with Cubitus interruptus (Ci) underlying Hedgehog-regulated Ci processing

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q02936&geneProductId=UniProtKB:Q02936

determination method

developmental pigmentation

determination method

1 reference

8 April 2019

Evolution in black and white: genetic control of pigment patterns in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

anterior/posterior lineage restriction, imaginal disc

determination method

1 reference

8 April 2019

Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

wing disc anterior/posterior pattern formation

determination method

4 references

8 April 2019

Sticking together and sorting things out: adhesion as a force in development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Pattern formation in the Drosophila wing: The development of the veins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Subdividing cell populations in the developing limbs of Drosophila: do wing veins and leg segments define units of growth control?

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

somatic stem cell division

determination method

1 reference

8 April 2019

The stem-cell niche theory: lessons from flies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

eye morphogenesis

determination method

1 reference

8 April 2019

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

heart formation

determination method

1 reference

8 April 2019

The wingless signaling pathway is directly involved in Drosophila heart development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

positive regulation of protein localization to cell surface

determination method

1 reference

8 April 2019

PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

regulation of epithelial cell migration, open tracheal system

determination method

1 reference

8 April 2019

Hedgehog is a positive regulator of FGF signalling during embryonic tracheal cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

smoothened signaling pathway

determination method

14 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

Regulation of smoothened by Drosophila G-protein-coupled receptor kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

1 January 2018

Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

segment polarity determination

determination method

8 references

8 April 2019

The evolution of arthropod segmentation mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The product of hedgehog autoproteolytic cleavage active in local and long-range signalling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Molecular organization and embryonic expression of the hedgehog gene involved in cell-cell communication in segmental patterning of Drosophila

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

imaginal disc-derived wing morphogenesis

determination method

1 reference

8 April 2019

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

heart development

determination method

1 reference

8 April 2019

Genetics of heart development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

terminal cell fate specification, open tracheal system

determination method

1 reference

8 April 2019

A rapid genome-wide microRNA screen identifies miR-14 as a modulator of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

positive regulation of nucleocytoplasmic transport

determination method

1 reference

8 April 2019

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

wing disc pattern formation

determination method

1 reference

8 April 2019

The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

cell fate specification

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

smoothened signaling pathway

determination method

15 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Regulation of smoothened by Drosophila G-protein-coupled receptor kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The extracellular loops of Smoothened play a regulatory role in control of Hedgehog pathway activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The fused protein kinase regulates Hedgehog-stimulated transcriptional activation in Drosophila Schneider 2 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

The long-range activity of Hedgehog is regulated in the apical extracellular space by the glypican Dally and the hydrolase Notum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

regulation of gene expression

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q02936

determination method

Intein N-terminal splicing region

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02936

Hedgehog, N-terminal signalling domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02936

Hint domain C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02936

Hedgehog protein, Hint domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02936

Hint domain N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q02936

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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