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Immune deficiency Dmel_CG5576
Protein found in Drosophila melanogaster
imd-PB
immune deficient
immunodeficiency
CG5576-PA
imd
CG5576-PB
imd-PA
CG5576 gene product from transcript CG5576-RB
immune deficiency
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q7K4Z4
part of
Death-like domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q7K4Z4
Death domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Drosophila melanogaster
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q7K4Z4
encoded by
imd
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q7K4Z4
molecular function
protein binding
determination method
IPI
2 references
retrieved
8 April 2019
stated in
The Drosophila immune defense against gram-negative infection requires the death protein dFADD.
GOA
curator
UniProt
UniProt protein ID
Q7K4Z4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IPI
retrieved
8 April 2019
stated in
Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IPI
death domain binding
determination method
IPI
1 reference
retrieved
8 April 2019
stated in
The Drosophila immune defense against gram-negative infection requires the death protein dFADD.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IPI
cell component
intracellular anatomical structure
determination method
NAS
1 reference
retrieved
16 July 2018
stated in
Role of Toll-like receptors in pathogen recognition.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4
determination method
NAS
cytosol
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
TAS
biological process
positive regulation of defense response to virus by host
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
A Novel System for the Launch of Alphavirus RNA Synthesis Reveals a Role for the Imd Pathway in Arthropod Antiviral Response
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
defense response
determination method
TAS
1 reference
retrieved
7 November 2018
stated in
The antimicrobial host defense of Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4
determination method
TAS
immune response
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
humoral immune response
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Characterization of an immunodeficiency mutant in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
positive regulation of antibacterial peptide biosynthetic process
determination method
IMP
2 references
retrieved
8 April 2019
stated in
Regulated nuclear import of Rel proteins in the Drosophila immune response.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
retrieved
8 April 2019
stated in
A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Iap2 is required for a sustained response in the Drosophila Imd pathway.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
signal transduction
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IEA
nervous system development
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
RNA interference screen to identify genes required for Drosophila embryonic nervous system development.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
response to bacterium
determination method
NAS
1 reference
retrieved
8 April 2019
stated in
Flies kNOw how to signal.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
NAS
antimicrobial humoral response
determination method
IGI
IMP
2 references
retrieved
7 November 2018
stated in
Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
retrieved
7 November 2018
stated in
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4
determination method
IGI
antibacterial humoral response
determination method
IMP
2 references
retrieved
8 April 2019
stated in
A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
retrieved
8 April 2019
stated in
Characterization of an immunodeficiency mutant in Drosophila.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
intracellular signal transduction
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
Drosophila: the genetics of innate immune recognition and response
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
TAS
defense response to bacterium
determination method
TAS
1 reference
retrieved
8 April 2019
stated in
The evolution and genetics of innate immunity
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
TAS
innate immune response
determination method
NAS
1 reference
retrieved
16 July 2018
stated in
The complexity of genetic variation in a simple immune system
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4
determination method
NAS
positive regulation of innate immune response
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
defense response to Gram-negative bacterium
determination method
TAS
2 references
retrieved
8 April 2019
stated in
Role of Toll-like receptors in pathogen recognition.
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
TAS
retrieved
8 April 2019
stated in
Drosophila: the genetics of innate immune recognition and response
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
TAS
peptidoglycan recognition protein signaling pathway
determination method
IMP
3 references
retrieved
8 April 2019
stated in
Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study
GOA
curator
UniProt
UniProt protein ID
Q7K4Z4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
retrieved
8 April 2019
stated in
The Drosophila caspase Dredd is required to resist gram-negative bacterial infection
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
retrieved
8 April 2019
stated in
Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
immune system process
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q7K4Z4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IEA
innate immune response
determination method
IEA
NAS
2 references
retrieved
1 January 2018
stated in
The complexity of genetic variation in a simple immune system
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4
determination method
NAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q7K4Z4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q7K4Z4&geneProductId=UniProtKB:Q7K4Z4
determination method
IEA
positive regulation of antibacterial peptide production
determination method
IGI
1 reference
retrieved
8 April 2019
stated in
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IGI
antimicrobial humoral response
determination method
IMP
1 reference
retrieved
8 April 2019
stated in
Inhibitor of apoptosis 2 and TAK1-binding protein are components of the Drosophila Imd pathway
GOA
curator
FlyBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IMP
innate immune response
determination method
IEA
1 reference
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q7K4Z4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q7K4Z4
determination method
IEA
has part(s)
Death domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/Q7K4Z4
Identifiers
RefSeq protein ID
NP_001286572
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
44339
NP_573394
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
44339
UniProt protein ID
Q7K4Z4
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
Q7K4Z4
Ensembl protein ID
FBpp0311815
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0311815
FBpp0085904
1 reference
stated in
ensembl Release 106
Ensembl protein ID
FBpp0085904
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