(Q29819808)

http://www.ebi.ac.uk/interpro/protein/P19538

Zinc finger C2H2-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Drosophila melanogaster

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II transcription regulatory region sequence-specific DNA binding

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

10 September 2018

Odd paired transcriptional activation of decapentaplegic in the Drosophila eye/antennal disc is cell autonomous but indirect.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

10 September 2018

Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

DNA-binding transcription activator activity, RNA polymerase II-specific

IGI

1 reference

10 September 2018

Odd paired transcriptional activation of decapentaplegic in the Drosophila eye/antennal disc is cell autonomous but indirect.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

DNA-binding transcription factor activity

1 reference

10 September 2018

Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

16 references

8 April 2019

A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

A protein interaction map of Drosophila melanogaster

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

identical protein binding

IPI

1 reference

8 April 2019

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

protein homodimerization activity

IPI

1 reference

8 April 2019

Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

8 April 2019

Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

DNA-binding transcription activator activity, RNA polymerase II-specific

IGI

sequence-specific DNA binding

1 reference

8 April 2019

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

10 references

8 April 2019

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Sequential phosphorylation of smoothened transduces graded hedgehog signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

4 references

10 September 2018

The role of segment polarity genes during early oogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

Hedgehog signaling complex

1 reference

8 April 2019

Identification of a tetrameric hedgehog signaling complex.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

protein-containing complex

IPI

1 reference

8 April 2019

Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

The role of segment polarity genes during early oogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes

biological process

mucosal immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

transcription, DNA-templated

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

regulation of transcription, DNA-templated

3 references

27 February 2018

Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

27 February 2018

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

transcription by RNA polymerase II

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

smoothened signaling pathway

8 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

Regulation of Hedgehog signaling: a complex story

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

Regulation of Cell Cycles in Drosophila Development: Intrinsic and Extrinsic Cues

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

Selector and signalling molecules cooperate in organ patterning

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

The ihog cell-surface proteins bind Hedgehog and mediate pathway activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

An absolute requirement for Cubitus interruptus in Hedgehog signaling.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

The role of segment polarity genes during early oogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

multicellular organism development

IEP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

regulation of mitotic cell cycle

1 reference

8 April 2019

Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

Conservation of the segmented germband stage: robustness or pleiotropy?

blastoderm segmentation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

ovarian follicle cell development

TAS

1 reference

8 April 2019

Integration of epithelial patterning and morphogenesis in Drosophila ovarian follicle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

positive regulation of epithelial cell differentiation

TAS

1 reference

8 April 2019

The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

cuticle pattern formation

1 reference

8 April 2019

Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts.

labial disc development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

genital disc anterior/posterior pattern formation

1 reference

8 April 2019

Expression patterns of developmental genes reveal segment and parasegment organization of D. melanogaster genital discs.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

spiracle morphogenesis, open tracheal system

IEP

1 reference

8 April 2019

Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

positive regulation of transcription by RNA polymerase II

4 references

10 September 2018

Cholesterol metabolism and embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

10 September 2018

Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

wing disc anterior/posterior pattern formation

1 reference

8 April 2019

The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

1 reference

7 November 2018

The role of segment polarity genes during early oogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P19538&geneProductId=UniProtKB:P19538

1 reference

8 April 2019

Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

Functional genomic analyses of two morphologically distinct classes of Drosophila sensory neurons: post-mitotic roles of transcription factors in dendritic patterning

dendrite morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

1 reference

8 April 2019

The wingless signaling pathway is directly involved in Drosophila heart development.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

positive regulation of G1/S transition of mitotic cell cycle

1 reference

8 April 2019

Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

positive regulation of TORC1 signaling

1 reference

8 April 2019

Spatial Activation of TORC1 Is Regulated by Hedgehog and E2F1 Signaling in the Drosophila Eye.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

regulation of transcription, DNA-templated

IGI

regulation of transcription, DNA-templated

NAS

TAS

1 reference

8 April 2019

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

smoothened signaling pathway

NAS

9 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

An absolute requirement for Cubitus interruptus in Hedgehog signaling.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

The role of segment polarity genes during early oogenesis in Drosophila.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

positive regulation of transcription by RNA polymerase II

3 references

8 April 2019

Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

8 April 2019

Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P19538

has part(s)

Zinc finger C2H2-type

1 reference

stated in

InterPro Release 71.0