(Q301630)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BYF1

Collectrin domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

peptidyl-dipeptidase activity

1 reference

8 April 2019

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein

IDA

virus receptor activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

1 reference

8 April 2019

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

TAS

endopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

3 references

8 April 2019

Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

carboxypeptidase activity

IPI

6 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

17 October 2017

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

17 October 2017

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

17 October 2017

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

17 October 2017

Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

17 October 2017

Cloning and characterization of a secreted form of angiotensin-converting enzyme 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

metallopeptidase activity

1 reference

8 April 2019

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

metallocarboxypeptidase activity

IDA

3 references

8 April 2019

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

carboxypeptidase activity

EXP

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

Cloning and characterization of a secreted form of angiotensin-converting enzyme 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

exopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

2 references

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

17 October 2017

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

2 references

8 April 2019

TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

1 reference

8 April 2019

Lipid rafts are involved in SARS-CoV entry into Vero E6 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

1 reference

17 October 2017

Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

2 references

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

brush border membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

regulation of cardiac conduction

biological process

1 reference

8 April 2019

Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

angiotensin-mediated drinking behavior

IMP

1 reference

8 April 2019

Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

2 references

regulation of cytokine production

1 reference

8 April 2019

Cloning and characterization of a secreted form of angiotensin-converting enzyme 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

positive regulation of reactive oxygen species metabolic process

1 reference

8 April 2019

Cloning and characterization of a secreted form of angiotensin-converting enzyme 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

regulation of vasoconstriction

1 reference

8 April 2019

Cloning and characterization of a secreted form of angiotensin-converting enzyme 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

regulation of cell population proliferation

1 reference

8 April 2019

ACE2: a new target for cardiovascular disease therapeutics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

positive regulation of cardiac muscle contraction

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

regulation of inflammatory response

1 reference

8 April 2019

Cloning and characterization of a secreted form of angiotensin-converting enzyme 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

positive regulation of gap junction assembly

1 reference

8 April 2019

Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

viral entry into host cell

IMP

1 reference

8 April 2019

ACE2: from vasopeptidase to SARS virus receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

regulation of systemic arterial blood pressure by renin-angiotensin

2 references

17 October 2017

Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

17 October 2017

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

blood vessel diameter maintenance

1 reference

8 April 2019

Cloning and characterization of a secreted form of angiotensin-converting enzyme 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYF1&geneProductId=UniProtKB:Q9BYF1

angiotensin maturation

1 reference

17 October 2017

receptor-mediated virion attachment to host cell

TAS

1 reference

8 April 2019

Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

regulation of systemic arterial blood pressure by renin-angiotensin

IDA

3 references

8 April 2019

Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

positive regulation of amino acid transport

1 reference

8 April 2019

Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYF1

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

IMP

Gene Atlas image

PBB GE ACE2 219962 at fs.png
732 × 530; 10 KB

0 references

depicted by

URL

https://science.sciencemag.org/content/sci/early/2020/03/03/science.abb2762/F4.large.jpg

contains

SARS-CoV-2

fabrication method

cryogenic electron microscopy

0 references

exact match

http://purl.uniprot.org/uniprot/Q9BYF1

1 reference

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BYF1

Identifiers

MeSH descriptor ID

D000085962

subject named as

Angiotensin-Converting Enzyme 2

0 references

MeSH tree code

D08.811.277.656.350.245.042

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

28 October 2013

Guide to Pharmacology Target ID

1614

1 reference

https://www.guidetopharmacology.org/coronavirus.jsp

22 April 2020

0 references

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

Transporter Classification Database ID

English

2.A.22.6.3

2 references

Transporter Classification database

retrieved

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata