(Q30165392)

9 June 2017

1 reference

title

The Nck family of adapter proteins: regulators of actin cytoskeleton (English)

1 reference

9 June 2017

0 references

0 references

László Buday

1

1 reference

PubMed ID

12034353

9 June 2017

Livius Wunderlich

series ordinal

2

1 reference

PubMed ID

12034353

9 June 2017

Peter Tamás

series ordinal

3

1 reference

9 June 2017

1 September 2002

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9 June 2017

9

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inferred from page(s)

published in

Cellular Signalling

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9 June 2017

14

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9 June 2017

723-731

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9 June 2017

9

1 reference

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

9 June 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Identification of Nck family genes, chromosomal localization, expression, and signaling specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2).

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Localization of human ARF2 and NCK genes and 13 other NotI-linking clones to chromosome 3 by fluorescence in situ hybridization.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Binding of NCK to SOS and activation of ras-dependent gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Dominant-negative mutants of the SH2/SH3 adapters Nck and Grb2 inhibit MAP kinase activation and mesoderm-specific gene induction by eFGF in Xenopus

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

SH2/SH3 signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Recruitment of Dok-R to the EGF receptor through its PTB domain is required for attenuation of Erk MAP kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Hepatocyte growth factor induces activation of Nck and phospholipase C-gamma in lung carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The multiple endocrine neoplasia type 2B point mutation switches the specificity of the Ret tyrosine kinase towards cellular substrates that are susceptible to interact with Crk and Nck

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Characterization of a novel member of the DOK family that binds and modulates Abl signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Inhibition of the motility and growth of B16F10 mouse melanoma cells by dominant negative mutants of Dok-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

SH2 domains recognize specific phosphopeptide sequences

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

A single point mutation switches the specificity of group III Src homology (SH) 2 domains to that of group I SH2 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Prediction and analysis of SH2 domain-phosphopeptide interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

A Novel Ligand for SH3 Domains

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Activation of the Abl tyrosine kinase in vivo by Src homology 3 domains from the Src homology 2/Src homology 3 adaptor Nck.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Requirement of multiple SH3 domains of Nck for ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

A casein kinase I activity is constitutively associated with Nck.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Identification and kinetic analysis of the interaction between Nck-2 and DOCK180

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

SH3 binding domains in the dopamine D4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Characterization of interactions of Nck with Sos and dynamin

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Identification of a mouse p21Cdc42/Rac activated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

R-Ras contains a proline-rich site that binds to SH3 domains and is required for integrin activation by R-Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adaptor protein that is developmentally regulated during cardiac myocyte differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

TNIK, a novel member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

MAP kinase pathways in yeast: for mating and more

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Signaling by the germinal center kinase family of protein kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

1 reference

7 January 2021

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Mechanism of activation of Pak1 kinase by membrane localization

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

A novel regulator of p21-activated kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Interaction of paxillin with p21-activated Kinase (PAK). Association of paxillin alpha with the kinase-inactive and the Cdc42-activated forms of PAK3.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Cell adhesion regulates the interaction between Nck and p21-activated kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Signaling to actin dynamics

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

A new LIM protein containing an autoepitope homologous to "senescent cell antigen"

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The Ste20 kinase misshapen regulates both photoreceptor axon targeting and dorsal closure, acting downstream of distinct signals

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2802%2900027-X

7 January 2021

10.1016/S0898-6568(02)00027-X

Identifiers

DOI

1 reference

9 June 2017

1 reference

PubMed ID

12034353