(Q30277715)

16 August 2017

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53. (English)

1 reference

16 August 2017

Alberto Podjarny

10

0 references

author name string

Denise Martinez-Zapien

1

1 reference

16 August 2017

Francesc Xavier Ruiz

2

1 reference

16 August 2017

Juline Poirson

3

1 reference

16 August 2017

André Mitschler

4

1 reference

16 August 2017

Juan Ramirez

5

1 reference

16 August 2017

Anne Forster

6

1 reference

16 August 2017

Alexandra Cousido-Siah

7

1 reference

16 August 2017

Murielle Masson

8

1 reference

16 August 2017

Scott Vande Pol

9

1 reference

16 August 2017

Gilles Travé

11

1 reference

16 August 2017

Katia Zanier

12

1 reference

16 August 2017

language of work or name

English

0 references

publication date

20 January 2016

1 reference

16 August 2017

1 reference

16 August 2017

529

1 reference

16 August 2017

541-545

1 reference

16 August 2017

7587

1 reference

describes a project that uses

16 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4853763/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Intracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides

1 reference

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The E6AP binding pocket of the HPV16 E6 oncoprotein provides a docking site for a small inhibitory peptide unrelated to E6AP, indicating druggability of E6

3 June 2018

1 reference

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Identification and characterization of small molecule human papillomavirus E6 inhibitors

3 June 2018

1 reference

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Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function

3 June 2018

1 reference

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The active form of E6-associated protein (E6AP)/UBE3A ubiquitin ligase is an oligomer

3 June 2018

1 reference

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Papillomavirus E6 oncoproteins

3 June 2018

1 reference

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Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins

3 June 2018

1 reference

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Peptide interactions stabilize and restructure human papillomavirus type 16 E6 to interact with p53

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53

3 June 2018

1 reference

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Benchmarking a luciferase complementation assay for detecting protein complexes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain

3 June 2018

1 reference

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p53 degradation activity, expression, and subcellular localization of E6 proteins from 29 human papillomavirus genotypes

3 June 2018

1 reference

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How viruses hijack cell regulation

3 June 2018

1 reference

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Degradation of p53 by human Alphapapillomavirus E6 proteins shows a stronger correlation with phylogeny than oncogenicity

3 June 2018

1 reference

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A synergistic approach to protein crystallization: combination of a fixed-arm carrier with surface entropy reduction.

3 June 2018

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

3 June 2018

1 reference

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MolProbity: all-atom structure validation for macromolecular crystallography

3 June 2018

1 reference

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Phasercrystallographic software

3 June 2018

1 reference

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Structure of the human p53 core domain in the absence of DNA

3 June 2018

1 reference

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Crystal structure of SV40 large T-antigen bound to p53: interplay between a viral oncoprotein and a cellular tumor suppressor

3 June 2018

1 reference

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Comparative analysis of 19 genital human papillomavirus types with regard to p53 degradation, immortalization, phylogeny, and epidemiologic risk classification

3 June 2018

1 reference

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Coot: model-building tools for molecular graphics

3 June 2018

1 reference

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Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells

3 June 2018

1 reference

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Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

High-risk human papillomavirus E6 protein has two distinct binding sites within p53, of which only one determines degradation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

Mutational analysis of human papillomavirus type 16 E6 protein: transforming function for human cells and degradation of p53 in vitro

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

Comprehensive control of human papillomavirus infections and related diseases.

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE16481

A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa cervical cancer cells.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE16481

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE16481

Comprehensive control of human papillomavirus infections and related diseases.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4853763

A sequence element of p53 that determines its susceptibility to viral oncoprotein-targeted degradation

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26789255

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NATURE16481

1 reference

Dimensions Publication ID

16 August 2017

1002339397

0 references

Fatcat ID

release_obhz6y4onbbbpixxwjjoxl3pbi

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/obhz6y4onbbbpixxwjjoxl3pbi

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

16 August 2017

1 reference