(Q30359686)

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Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association

scientific article

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scholarly article

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Europe PubMed Central

16 August 2017

Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association (English)

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Europe PubMed Central

16 August 2017

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Christian Delles

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Christian Delles

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Aldons Jake Lusis

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Aldons J Lusis

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Joseph Loscalzo

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Joseph Loscalzo

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L Kristin Newby

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L Kristin Newby

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Donna K Arnett

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Caroline S. Fox

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Caroline S Fox

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Christopher J O'Donnell

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Christopher J O'Donnell

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Mason W. Freeman

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Mason W Freeman

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Jennifer L Hall

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Euan A Ashley

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Mary B Engler

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Julie A Johnson

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David E Lanfear

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Stephen B Liggett

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Calum A MacRae

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Kiran Musunuru

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Stephen S Rich

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Andre Terzic

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American Heart Association Council on Functional Genomics and Translational Biology, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Quality of Care and Outcomes Research, and Council on Epidemiology and Prevention

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16 April 2015

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1715-1736

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16 August 2017

U.S. Food and Drug Administration approval summary: omacetaxine mepesuccinate as treatment for chronic myeloid leukemia

1 reference

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2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

1 reference

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Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association

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Cardiac structural and sarcomere genes associated with cardiomyopathy exhibit marked intolerance of genetic variation.

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The mammalian gene function resource: the International Knockout Mouse Consortium

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Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project

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Linking disease associations with regulatory information in the human genome

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Decoding the human genome

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An integrated encyclopedia of DNA elements in the human genome

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Classification of human genomic regions based on experimentally determined binding sites of more than 100 transcription-related factors

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Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function

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Association of trypanolytic ApoL1 variants with kidney disease in African Americans

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Uncovering the complexity of transcriptomes with RNA-Seq.

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Relationship of microparticles to progenitor cells as a measure of vascular health in a diabetic population

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Network systems biology for drug discovery

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Traversing the valley of death: a guide to assessing prospects for translational success

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PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations

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How to improve R&D productivity: the pharmaceutical industry's grand challenge

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Association between a literature-based genetic risk score and cardiovascular events in women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Cell fate specification in the C. elegans embryo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

A review of current large-scale mouse knockout efforts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

A high-resolution association mapping panel for the dissection of complex traits in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Defining the pathogenicity of DNA sequence variation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

WormBase: a comprehensive resource for nematode research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Drug-sensitized zebrafish screen identifies multiple genes, including GINS3, as regulators of myocardial repolarization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

The pre-clinical animal model in the translational research of interventional cardiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Systems genetics of complex traits in Drosophila melanogaster

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Estimation of the warfarin dose with clinical and pharmacogenetic data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Cytochrome p-450 polymorphisms and response to clopidogrel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Genetic determinants of response to clopidogrel and cardiovascular events

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Common variants at 30 loci contribute to polygenic dyslipidemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

MYH9 is associated with nondiabetic end-stage renal disease in African Americans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

An integrative genomics approach to infer causal associations between gene expression and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Molecular and cellular mechanisms of cardiac arrhythmias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

A receptor-mediated pathway for cholesterol homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Citrinin, an inhibitor of cholesterol synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Inhibition of in vitro cholesterol synthesis by fatty acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Purification and characterization of the two molecular forms of Aspergillus oryzae acid protease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

3 June 2018

Do pharmacogenetics have a role in the dosing of vitamin K antagonists?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

A randomized trial of genotype-guided dosing of warfarin.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

A randomized trial of genotype-guided dosing of acenocoumarol and phenprocoumon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

Personalized antiplatelet therapy according to CYP2C19 genotype after percutaneous coronary intervention: a randomized control trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

TALEN-mediated precise genome modification by homologous recombination in zebrafish.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

Integrating clinical pharmacology concepts in individualized therapy with tyrosine kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

Neoadjuvant chemotherapy and bevacizumab for HER2-negative breast cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

Next-generation genome-wide association studies: time to focus on phenotype?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration: a systematic meta-analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

Genetics of atherosclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4825323

26 November 2018

Presenting ENCODE

1 reference

https://pubmed.ncbi.nlm.nih.gov/25882488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/25882488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and biological activity of the active metabolite of clopidogrel

1 reference

https://pubmed.ncbi.nlm.nih.gov/25882488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disparities in incidence of diabetic end-stage renal disease according to race and type of diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25882488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational research: Crossing the valley of death

1 reference

https://pubmed.ncbi.nlm.nih.gov/25882488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol-lowering blockbuster candidates speed into Phase III trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/25882488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/25882488

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIR.0000000000000211

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

1 reference

Europe PubMed Central

16 August 2017

ResearchGate publication ID

0 references

Sitelinks

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