(Q30427620)

21 June 2017

1 reference

title

The adenomatous polyposis coli (APC) tumor suppressor (English)

1 reference

21 June 2017

1 reference

P Polakis

1

1 reference

PubMed ID

9196022

21 June 2017

language of work or name

English

0 references

publication date

1 June 1997

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Biochimica et Biophysica Acta

21 June 2017

1 reference

21 June 2017

1332

1 reference

21 June 2017

F127-47

1 reference

21 June 2017

3

1 reference

Identification of FAP locus genes from chromosome 5q21

21 June 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Identification of deletion mutations and three new genes at the familial polyposis locus

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

APC mutations occur early during colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

APC gene: database of germline and somatic mutations in human tumors and cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Mutations in the APC gene and their implications for protein structure and function

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Association of the APC gene product with beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Association of the APC tumor suppressor protein with catenins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Genotype-phenotype correlations of new causative APC gene mutations in patients with familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Familial adenomatous polyposis: desmoid tumours and lack of ophthalmic lesions (CHRPE) associated with APC mutations beyond codon 1444.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Restriction of ocular fundus lesions to a specific subgroup of APC mutations in adenomatous polyposis coli patients.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Genotype-phenotype correlation between position of constitutional APC gene mutation and CHRPE expression in familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Phenotypic expression in familial adenomatous polyposis: partial prediction by mutation analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Familial adenomatous polyposis: mutation at codon 1309 and early onset of colon cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP).

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Suppression of intestinal neoplasia by DNA hypomethylation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

A genetic model for colorectal tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome).

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Alpha-helical coiled coils: more facts and better predictions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

A repeating amino acid motif shared by proteins with diverse cellular roles

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Pendulin, a Drosophila protein with cell cycle-dependent nuclear localization, is required for normal cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Isolation of a protein that is essential for the first step of nuclear protein import

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

PF16 encodes a protein with armadillo repeats and localizes to a single microtubule of the central apparatus in Chlamydomonas flagella

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Secondary structure of an armadillo single repeat from the APC protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Functional interaction of beta-catenin with the transcription factor LEF-1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

beta-Catenin associates with the actin-bundling protein fascin in a noncadherin complex

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Identification and characterization of the familial adenomatous polyposis coli gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

A short core region of E-cadherin is essential for catenin binding and is highly phosphorylated

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Analysis of the primary sequence and microtubule-binding region of the Drosophila 205K MAP

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Microtubule-associated protein MAP2 shares a microtubule binding motif with tau protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Turcot's syndrome: evidence for linkage to the adenomatous polyposis coli (APC) locus.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The molecular basis of Turcot's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Overexpression of cadherins and underexpression of beta-catenin inhibit dorsal mesoderm induction in early Xenopus embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Signal transduction of beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Cell adhesion and signal transduction: the Armadillo connection

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

c-erbB-2 gene product directly associates with beta-catenin and plakoglobin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Single amino acid substitutions in proteins of the armadillo gene family abolish their binding to alpha-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Deletion of an amino-terminal sequence beta-catenin in vivo and promotes hyperphosporylation of the adenomatous polyposis coli tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Tumor suppression in Drosophila is causally related to the function of the lethal(2) tumorous imaginal discs gene, a dnaJ homolog.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

In situ detection of enterocytic apoptosis in normal colonic mucosa and in familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Synergy between Apc min and an activated ras mutation is sufficient to induce colon carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Components of wingless signalling in Drosophila.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

A new member of the frizzled family from Drosophila functions as a Wingless receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The dishevelled protein is modified by wingless signaling in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Signal transduction through beta-catenin and specification of cell fate during embryogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Injected Wnt RNA induces a complete body axis in Xenopus embryos

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Adenomatous polyposis coli tumor suppressor protein has signaling activity in Xenopus laevis embryos resulting in the induction of an ectopic dorsoanterior axis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

A soluble form of Wnt-1 protein with mitogenic activity on mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

ApcMin: a mouse model for intestinal and mammary tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Loss of E-cadherin-dependent cell-cell adhesion due to mutation of the beta-catenin gene in a human cancer cell line, HSC-39

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Expression cloning of oncogenes by retroviral transfer of cDNA libraries

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Age of onset in familial adenomatous polyposis: heterogeneity within families and among APC mutations.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Identical APC exon 15 mutations result in a variable phenotype in familial adenomatous polyposis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Phenotypic variability of familial adenomatous polyposis in 11 unrelated families with identical APC gene mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Attenuated familial adenomatous polyposis (AFAP). A phenotypically and genotypically distinctive variant of FAP.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Alleles of the APC gene: an attenuated form of familial polyposis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

APC mutation associated with late onset of familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Mutation in a splice-donor site of the APC gene in a family with polyposis and late age of colonic cancer death

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

APC mutation in the alternatively spliced region of exon 9 associated with late onset familial adenomatous polyposis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

Novel germline APC gene mutation in a large familial adenomatous polyposis kindred displaying variable phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2897%2900008-5

7 January 2021

10.1016/S0304-419X(97)00008-5

Identifiers

DOI

1 reference

21 June 2017

1 reference

PubMed ID

9196022