(Q30495754)

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CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

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scholarly article

1 reference

Europe PubMed Central

19 October 2017

CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations (English)

1 reference

Europe PubMed Central

19 October 2017

0 references

Serine/threonine kinase 25a

1 reference

GOA release 2020-03-11

CCM2 scaffold protein

1 reference

GOA release 2020-03-11

Programmed cell death 10b

1 reference

GOA release 2020-03-11

Programmed cell death 10a

1 reference

GOA release 2020-03-11

circulatory system

1 reference

based on heuristic

inferred from title

Annarita Di Lorenzo

3

1 reference

Europe PubMed Central

19 October 2017

Xiangjian Zheng

object named as

Xiangjian Zheng

1

0 references

William C. Sessa

12

object named as

William C Sessa

1 reference

Europe PubMed Central

19 October 2017

author name string

Chong Xu

2

1 reference

Europe PubMed Central

19 October 2017

Benjamin Kleaveland

4

1 reference

Europe PubMed Central

19 October 2017

Zhiying Zou

5

1 reference

Europe PubMed Central

19 October 2017

Christoph Seiler

6

1 reference

Europe PubMed Central

19 October 2017

Mei Chen

7

1 reference

Europe PubMed Central

19 October 2017

Lan Cheng

8

1 reference

Europe PubMed Central

19 October 2017

Jiping Xiao

9

1 reference

Europe PubMed Central

19 October 2017

Jie He

10

1 reference

Europe PubMed Central

19 October 2017

Michael A Pack

11

1 reference

Europe PubMed Central

19 October 2017

Mark L Kahn

13

1 reference

Europe PubMed Central

19 October 2017

language of work or name

0 references

publication date

1 July 2010

1 reference

Europe PubMed Central

19 October 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

19 October 2017

120

1 reference

Europe PubMed Central

19 October 2017

2795-2804

1 reference

Europe PubMed Central

19 October 2017

8

1 reference

Europe PubMed Central

19 October 2017

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Novel CCM1, CCM2, and CCM3 mutations in patients with cerebral cavernous malformations: in-frame deletion in CCM2 prevents formation of a CCM1/CCM2/CCM3 protein complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

CCM3 mutations are uncommon in cerebral cavernous malformations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Epithelial cell shape and Rho small GTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Mutations in apoptosis-related gene, PDCD10, cause cerebral cavernous malformation 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Mutations within the programmed cell death 10 gene cause cerebral cavernous malformations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Sensitive genetic biomarkers for determining apoptosis in the brown bullhead (Ameiurus nebulosus).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Mutations within the MGC4607 gene cause cerebral cavernous malformations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Genome-wide RNAi screening in Caenorhabditis elegans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Mutations in the gene encoding KRIT1, a Krev-1/rap1a binding protein, cause cerebral cavernous malformations (CCM1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational change

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Association of Krev-1/rap1a with Krit1, a novel ankyrin repeat-containing protein encoded by a gene mapping to 7q21-22

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Lysophosphatidic acid increases tight junction permeability in cultured brain endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Cerebral cavernous malformations. Incidence and familial occurrence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

20 June 2018

Proteomic identification of the cerebral cavernous malformation signaling complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

26 November 2018

Interaction between krit1 and malcavernin: implications for the pathogenesis of cerebral cavernous malformations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

26 November 2018

santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

26 November 2018

Ultrastructural characteristics of hemorrhagic, nonhemorrhagic, and recurrent cavernous malformations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

26 November 2018

Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

26 November 2018

Zebrafish intestinal fatty acid binding protein (I-FABP) gene promoter drives gut-specific expression in stable transgenic fish.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

26 November 2018

heart of glass regulates the concentric growth of the heart in zebrafish.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

26 November 2018

Ultrastructural pathological features of cerebrovascular malformations: a preliminary report.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2912181

26 November 2018

C-terminal threonine phosphorylation activates ERM proteins to link the cell's cortical lipid bilayer to the cytoskeleton

1 reference

https://pubmed.ncbi.nlm.nih.gov/20592472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognizing and defining true Ras binding domains I: biochemical analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20592472

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI39679

1 reference

Europe PubMed Central

19 October 2017

1 reference

Europe PubMed Central

19 October 2017

1 reference

Europe PubMed Central

19 October 2017

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