(Q30807030)

26 June 2017

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title

Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature (English)

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26 June 2017

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Klump B

1

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26 June 2017

Nehls O

2

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26 June 2017

Okech T

3

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26 June 2017

Hsieh CJ

4

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26 June 2017

Gaco V

5

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26 June 2017

Gittinger FS

6

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26 June 2017

Sarbia M

7

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26 June 2017

Borchard F

8

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26 June 2017

Greschniok A

9

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26 June 2017

Gruenagel HH

10

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26 June 2017

Porschen R

11

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26 June 2017

Gregor M

12

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26 June 2017

21 June 2003

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International Journal of Colorectal Disease

26 June 2017

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26 June 2017

19

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26 June 2017

23-42

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26 June 2017

1

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https://scigraph.springernature.com/pub.10.1007/s00384-003-0499-7

26 June 2017

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Expression of the deleted in colorectal cancer gene is related to prognosis in DNA diploid and low proliferative colorectal adenocarcinoma

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Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

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12 December 2020

Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival

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Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma

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Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: preliminary report from an ongoing trial.

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Thymidylate synthase gene amplification in human colon cancer cell lines resistant to 5-fluorouracil

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K-ras gene mutation as a pathogenetic and diagnostic marker in human cancer

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Prognostic significance of p53 abnormalities in colorectal carcinoma detected by PCR-SSCP and immunohistochemical analysis

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12 December 2020

Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance

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12 December 2020

High basal level gene expression of thymidine phosphorylase (platelet-derived endothelial cell growth factor) in colorectal tumors is associated with nonresponse to 5-fluorouracil.

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12 December 2020

P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma

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12 December 2020

Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer

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12 December 2020

Molecular genetics of colorectal cancer

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12 December 2020

Colorectal liver metastasis thymidylate synthase staining correlates with response to hepatic arterial floxuridine

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12 December 2020

K-ras status does not predict successful hepatic resection of colorectal cancer metastasis

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Clues to the pathogenesis of familial colorectal cancer

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12 December 2020

p53 immunoreaction in endoscopic biopsy specimens of colorectal cancer, and its prognostic significance

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12 December 2020

Relationship among p53, stage, and prognosis of large bowel cancer

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12 December 2020

Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy

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12 December 2020

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12 December 2020

Dukes B colorectal cancer: distinct genetic categories and clinical outcome based on proximal or distal tumor location

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12 December 2020

Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator

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12 December 2020

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

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12 December 2020

Where do we stand with 5-fluorouracil?

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12 December 2020

Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers

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12 December 2020

Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas

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12 December 2020

K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers

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12 December 2020

DCC protein as a predictor of distant metastases after curative surgery for rectal cancer.

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12 December 2020

Prognostic role of thymidylate synthase, thymidine phosphorylase/platelet-derived endothelial cell growth factor, and proliferation markers in colorectal cancer

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12 December 2020

Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability

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12 December 2020

Microsatellite instability and high content of activated cytotoxic lymphocytes identify colon cancer patients with a favorable prognosis

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12 December 2020

Microsatellite instability in cancer of the proximal colon

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12 December 2020

Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer

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12 December 2020

Higher levels of thymidylate synthase gene expression are observed in pulmonary as compared with hepatic metastases of colorectal adenocarcinoma

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12 December 2020

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

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12 December 2020

Regulation of thymidylate synthetase activity in cultured mammalian cells

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12 December 2020

Coexpression of Bcl-2, c-Myc, and p53 oncoproteins as prognostic discriminants in patients with colorectal carcinoma

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12 December 2020

Prognostic significance of K-ras and TP53 mutations in the role of adjuvant chemotherapy on survival in patients with Dukes C colon cancer

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12 December 2020

The DCC gene suppresses the malignant phenotype of transformed human epithelial cells

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12 December 2020

An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms

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12 December 2020

Influence of p53 status on prognosis in preoperatively irradiated rectal carcinoma

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12 December 2020

A genetic model for colorectal tumorigenesis

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12 December 2020

Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma

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12 December 2020

DCC: linking tumour suppressor genes and altered cell surface interactions in cancer?

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12 December 2020

Prognostic markers for colorectal cancer: expression of P53 and BCL2.

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12 December 2020

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major

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12 December 2020

Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile

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12 December 2020

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12 December 2020

Thymidylate synthase protein expression in advanced colon cancer: correlation with the site of metastasis and the clinical response to leucovorin-modulated bolus 5-fluorouracil

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12 December 2020

Reduced expression of deleted colorectal carcinoma (DCC) protein in established colon cancers

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12 December 2020

Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor

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12 December 2020

Prognostic significance of TP53 gene mutation in 995 cases of colorectal carcinoma. Influence of tumour site, stage, adjuvant chemotherapy and type of mutation

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12 December 2020

Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer

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12 December 2020

Implications of the p53 tumor-suppressor gene in clinical oncology.

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12 December 2020

Overexpression of cyclin D1 and p53 associated with disease recurrence in colorectal adenocarcinoma

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12 December 2020

Prognostic influence of p53 nuclear overexpression in colorectal carcinoma

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12 December 2020

Association of p53 mutations with short survival in colorectal cancer

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12 December 2020

Cytoplasmic accumulation of p53 protein: an independent prognostic indicator in colorectal adenocarcinomas.

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12 December 2020

Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: a Southwest Oncology Group study.

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12 December 2020

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history

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12 December 2020

Influence of tumor localization on the prognostic value of P53 protein in colorectal adenocarcinomas

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12 December 2020

Detection of DCC and Ki-ras gene alterations in colorectal carcinoma tissue as prognostic markers for liver metastatic recurrence

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12 December 2020

Decreased expression of DCC mRNA in human colorectal cancers

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12 December 2020

Overexpression of p53 and long-term survival in colon carcinoma

1 reference

12 December 2020

Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers

1 reference

12 December 2020

P53 mutations in primary tumors and subsequent liver metastases are related to survival in patients with colorectal carcinoma who undergo liver resection

1 reference

12 December 2020

p53 nuclear protein overexpression in colorectal cancer: a dominant predictor of survival in patients with advanced hepatic metastases

1 reference

12 December 2020

Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression.

1 reference

12 December 2020

Immunohistochemical determination of p53 protein does not predict clinical response in advanced colorectal cancer with low thymidylate synthase expression receiving a bolus 5-fluorouracil-leucovorin combination

1 reference

12 December 2020

Replication error in colorectal carcinoma: association with loss of heterozygosity at mismatch repair loci and clinicopathological variables

1 reference

12 December 2020

Thymidylate synthase protein expression in primary colorectal cancer compared with the corresponding distant metastases and relationship with the clinical response to 5-fluorouracil

1 reference

12 December 2020

Genetic mapping of a locus predisposing to human colorectal cancer

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12 December 2020

p53 nuclear overexpression may not be an independent prognostic marker in early colorectal cancer

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12 December 2020

The significance of allelic deletions and aneuploidy in colorectal carcinoma. Results of a 5-year follow-up study

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12 December 2020

The prognostic significance of p53 expression for survival and local control in rectal carcinoma treated with surgery and postoperative radiotherapy

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12 December 2020

Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases

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12 December 2020

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

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12 December 2020

Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis.

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12 December 2020

Cancer statistics, 1997.

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12 December 2020

Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity

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12 December 2020

Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer

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12 December 2020

p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer?

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12 December 2020

A new prognostic factor for colorectal carcinoma, thymidylate synthase, and its therapeutic significance

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12 December 2020

p53 nuclear overexpression: an independent predictor of survival in lymph node--positive colorectal cancer patients.

1 reference

12 December 2020

Expression of platelet-derived endothelial cell growth factor correlates with good prognosis in patients with colorectal carcinoma

1 reference

12 December 2020

Microsatellite instability is a favorable prognostic indicator in patients with colorectal cancer receiving chemotherapy

1 reference

12 December 2020

Vascular endothelial growth factor expression, S-phase fraction and thymidylate synthase quantitation in node-positive colon cancer: relationships with tumor recurrence and resistance to adjuvant chemotherapy

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12 December 2020

p53 point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival.

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12 December 2020

The DCC protein and prognosis in colorectal cancer

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12 December 2020

Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma

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12 December 2020

K-ras and p16 aberrations confer poor prognosis in human colorectal cancer

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12 December 2020

p53 in colorectal cancer: clinicopathological correlation and prognostic significance

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12 December 2020

Thymidylate synthase expression: an independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer

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12 December 2020

The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer

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12 December 2020

Enzymes of uracil catabolism in normal and neoplastic human tissues

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12 December 2020

Mutations of Ki-ras and p53 genes in colorectal cancer and their prognostic significance.

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12 December 2020

The spread of rectal cancer and its effect on prognosis

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12 December 2020

Loss of Bcl-2 expression correlates with tumour recurrence in colorectal cancer

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12 December 2020

Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors

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12 December 2020

p53 tumor suppressor gene mutations predict decreased survival of patients with sporadic colorectal carcinoma.

1 reference

12 December 2020

Loss of heterozygosity at 18q21 is indicative of recurrence and therefore poor prognosis in a subset of colorectal cancers.

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12 December 2020

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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12 December 2020

Association of tumour site and sex with survival benefit from adjuvant chemotherapy in colorectal cancer

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12 December 2020

Prognostic value of p53 overexpression and c-Ki-ras gene mutations in colorectal cancer

1 reference

12 December 2020

Molecular predictors of survival after adjuvant chemotherapy for colon cancer

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12 December 2020

Prediction of recurrence in B-C stages of colorectal cancer by p53 nuclear overexpression in comparison with standard pathological features

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12 December 2020

10.1007/S00384-003-0499-7

Identifiers

DOI

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Dimensions Publication ID

26 June 2017

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