(Q30839839)

27 June 2017

Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine (English)

1 reference

27 June 2017

1 reference

Hisaya Kawate

1

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27 June 2017

Daniel M Landis

series ordinal

2

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27 June 2017

Lawrence A Loeb

series ordinal

3

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27 June 2017

language of work or name

English

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publication date

29 July 2002

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Journal of Biological Chemistry

27 June 2017

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27 June 2017

277

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27 June 2017

36304-36311

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27 June 2017

39

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The catalytic mechanism and structure of thymidylate synthase

27 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Thymine metabolism and thymineless death in prokaryotes and eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Thymidylate synthase inhibitors in cancer therapy: direct and indirect inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Probing the folate-binding site of human thymidylate synthase by site-directed mutagenesis. Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Crystal structure of a deletion mutant of human thymidylate synthase Δ (7-29) and its ternary complex with Tomudex and dUMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

On the fidelity of DNA replication: manganese mutagenesis in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Fidelity of DNA synthesis by the Thermus aquaticus DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

21 January 2018

The Protein Data Bank

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Memory landscapes of single-enzyme molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Raster3D Version 2.0. A program for photorealistic molecular graphics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M204956200

21 January 2018

Identifiers

DOI

10.1074/JBC.M204956200

1 reference

27 June 2017

1 reference