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Integrin activation and structural rearrangement
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
12234369
retrieved
27 June 2017
review article
1 reference
stated in
Europe PubMed Central
title
Integrin activation and structural rearrangement
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
12234369
retrieved
27 June 2017
author name string
Junichi Takagi
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
12234369
retrieved
27 June 2017
Timothy A Springer
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
12234369
retrieved
27 June 2017
publication date
1 August 2002
1 reference
stated in
Europe PubMed Central
PubMed ID
12234369
retrieved
27 June 2017
published in
Immunological Reviews
1 reference
stated in
Europe PubMed Central
PubMed ID
12234369
retrieved
27 June 2017
volume
186
1 reference
stated in
Europe PubMed Central
PubMed ID
12234369
retrieved
27 June 2017
page(s)
141-163
1 reference
stated in
Europe PubMed Central
PubMed ID
12234369
retrieved
27 June 2017
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Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences
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The actin cytoskeleton regulates LFA-1 ligand binding through avidity rather than affinity changes
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Crystal structure of the extracellular segment of integrin alpha Vbeta3
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C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1
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The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding
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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand
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Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha 6beta 4
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Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation
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Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain
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Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface
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A novel Ca2+ binding beta hairpin loop better resembles integrin sequence motifs than the EF hand
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Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model
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A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding
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The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.
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Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)
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The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. Dependence on beta subunit association and prediction of domains.
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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Domains in plexins: links to integrins and transcription factors
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Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family
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Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2).
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Evolution of domain families
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Folding of the conserved domain but not of flanking regions in the integrin beta2 subunit requires association with the alpha subunit
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Crossref
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Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit
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Crossref
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Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3).
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The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3
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Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits
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Defining the repeating elements in the cysteine-rich region (CRR) of the CD18 integrin beta 2 subunit
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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation
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Crossref
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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Two conformations of the integrin A-domain (I-domain): a pathway for activation?
1 reference
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7 January 2021
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Cation binding to the integrin CD11b I domain and activation model assessment
1 reference
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Crossref
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
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Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin
1 reference
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Crossref
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based on heuristic
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The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin
1 reference
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Crossref
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NMR solution structure of the inserted domain of human leukocyte function associated antigen-1
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7 January 2021
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Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain
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Crystal structure of the I domain from integrin alpha2beta1
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Structural basis of collagen recognition by integrin alpha2beta1
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Crystal structure of the alpha1beta1 integrin I-domain: insights into integrin I-domain function
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Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM
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The integrin I domain: crystals, metals and related artefacts.
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The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus
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A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen
1 reference
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7 January 2021
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Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.
1 reference
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7 January 2021
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Computational design of an integrin I domain stabilized in the open high affinity conformation
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De novo protein design: fully automated sequence selection
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An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain
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Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
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An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
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Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding
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Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm
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Functional consequences of integrin gene mutations in mice
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Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
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Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead
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Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction
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7 January 2021
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Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties
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7 January 2021
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Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition
1 reference
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
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Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule
1 reference
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7 January 2021
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A discrete site modulates activation of I domains. Application to integrin alphaMbeta2.
1 reference
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Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib
1 reference
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
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Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1.
1 reference
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Crossref
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
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A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1)
1 reference
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Crossref
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
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Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
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Specific association of CD63 with the VLA-3 and VLA-6 integrins
1 reference
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7 January 2021
based on heuristic
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Alpha 4 beta 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
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Integrin cytoplasmic domains mediate inside-out signal transduction
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Breaking the integrin hinge. A defined structural constraint regulates integrin signaling
1 reference
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7 January 2021
based on heuristic
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Regulation of Adhesion to ICAM-1 by the Cytoplasmic Domain of LFA-1 Integrin β Subunit
1 reference
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Crossref
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https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transmembrane-truncated alphavbeta3 integrin retains high affinity for ligand binding: evidence for an 'inside-out' suppressor?
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7 January 2021
based on heuristic
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The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides
1 reference
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Crossref
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7 January 2021
based on heuristic
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Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).
1 reference
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7 January 2021
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Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Micromolar Ca2+ concentrations are essential for Mg2+-dependent binding of collagen by the integrin alpha 2beta 1 in human platelets
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mapping the intercellular adhesion molecule-1 and -2 binding site on the inserted domain of leukocyte function-associated antigen-1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1034/J.1600-065X.2002.18613.X
1 reference
stated in
Europe PubMed Central
PubMed ID
12234369
retrieved
27 June 2017
PubMed ID
12234369
1 reference
stated in
Europe PubMed Central
PubMed ID
12234369
retrieved
27 June 2017
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