(Q30992376)

28 June 2017

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title

Mass spectrometry innovations in drug discovery and development (English)

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28 June 2017

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Papac DI

1

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PubMed ID

11405282

28 June 2017

Shahrokh Z

series ordinal

2

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28 June 2017

1 February 2001

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28 June 2017

Pharmaceutical Research

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28 June 2017

18

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28 June 2017

131-145

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28 June 2017

2

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The glycosylation heterogeneity of recombinant human IFN-gamma

28 June 2017

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12 December 2020

Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening

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12 December 2020

Electrospray interface for liquid chromatographs and mass spectrometers

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12 December 2020

Application of evaporative light scattering detection to the characterization of combinatorial and parallel synthesis libraries for pharmaceutical drug discovery.

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12 December 2020

Evaluation of isotope ratio (IR) mass spectrometry for the study of drug metabolism

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12 December 2020

Screening for high-affinity ligands to the Src SH2 domain using capillary isoelectric focusing-electrospray ionization ion trap mass spectrometry

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12 December 2020

Characterization of SH2-ligand interactions via library affinity selection with mass spectrometric detection

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12 December 2020

Strategies and recent technologies in drug discovery

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12 December 2020

Analytical performance of accelerator mass spectrometry and liquid scintillation counting for detection of 14C-labeled atrazine metabolites in human urine.

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12 December 2020

Comparison of plasma sample purification by manual liquid-liquid extraction, automated 96-well liquid-liquid extraction and automated 96-well solid-phase extraction for analysis by high-performance liquid chromatography with tandem mass spectrometry

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12 December 2020

Error-tolerant identification of peptides in sequence databases by peptide sequence tags

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12 December 2020

Quantification and rapid metabolite identification in drug discovery using API time-of-flight LC/MS.

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12 December 2020

Liquid chromatography-mass spectrometry with on-line solid-phase extraction by a restricted-access C18 precolumn for direct plasma and urine injection

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12 December 2020

Application of capillary electrophoresis, liquid chromatography, electrospray-mass spectrometry and matrix-assisted laser desorption/ionization - time of flight - mass spectrometry to the characterization of recombinant human erythropoietin

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12 December 2020

Accelerator mass spectrometry

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12 December 2020

High-sensitivity analysis and sequencing of peptides and proteins by quadrupole ion trap mass spectrometry.

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12 December 2020

The use of high-performance anion-exchange chromatography and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to monitor and identify oligosaccharide degradation

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12 December 2020

Electrophoresis combined with novel mass spectrometry techniques: powerful tools for the analysis of proteins and proteomes.

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12 December 2020

Analytical properties of the nanoelectrospray ion source

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12 December 2020

Protein identification by peptide mass fingerprinting.

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12 December 2020

Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability

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12 December 2020

Performance of human mass balance studies with stable isotope-labeled drug and continuous flow-isotope ratio mass spectrometry: a progress report

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12 December 2020

Atmospheric pressure ionization LC/MS/MS techniques for drug disposition studies

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12 December 2020

Application of liquid chromatography-mass spectrometry(n) analyses to the characterization of novel glyburide metabolites formed in vitro

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12 December 2020

Assays of ligand-human serum albumin binding using pulsed ultrafiltration and liquid chromatography-mass spectrometry

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12 December 2020

Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry.

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12 December 2020

A novel interface for on-line coupling of liquid capillary chromatography with matrix-assisted laser desorption/ionization detection

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12 December 2020

Role of accurate mass measurement (+/- 10 ppm) in protein identification strategies employing MS or MS/MS and database searching.

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12 December 2020

Optimization of the cleavage reaction for cyanylated cysteinyl proteins for efficient and simplified mass mapping

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12 December 2020

Disulfide structure of the heparin binding domain in vascular endothelial growth factor: characterization of posttranslational modifications in VEGF.

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12 December 2020

Sample pooling to expedite bioanalysis and pharmacokinetic research

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12 December 2020

Differentiation of 'isobaric' peptides and human milk oligosaccharides by exact mass measurements using electrospray ionization orthogonal time-of-flight analysis

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12 December 2020

Towards an automated approach for protein identification in proteome projects

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12 December 2020

Accurate mass measurements using MALDI-TOF with delayed extraction

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12 December 2020

Capillary electrophoresis/electrospray ionization high mass accuracy time-of-flight mass spectrometry for protein identification using peptide mapping.

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12 December 2020

Mapping of recombinant hemoglobin using immobilized trypsin cartridges

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12 December 2020

A novel geometry mass spectrometer, the Q-TOF, for low-femtomole/attomole-range biopolymer sequencing

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12 December 2020

Cell line and site specific comparative analysis of the N-linked oligosaccharides on human ICAM-1des454-532 by electrospray ionization mass spectrometry

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12 December 2020

Moricizine bioavailability via simultaneous, dual, stable isotope administration: bioequivalence implications

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12 December 2020

Column-switching high-performance liquid chromatography combined with ionspray tandem mass spectrometry for the simultaneous determination of the platelet inhibitor Ro 44-3888 and its pro-drug and precursor metabolite in plasma

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12 December 2020

Characterization of the tryptic map of recombinant DNA derived tissue plasminogen activator by high-performance liquid chromatography-electrospray ionization mass spectrometry

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12 December 2020

Replacing 14C with stable isotopes in drug metabolism studies

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12 December 2020

Matrix-assisted laser desorption mass spectrometric analysis of a pegylated recombinant protein

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12 December 2020

Metabolite profiling study of propranolol in rat using LC/MS/MS analysis

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12 December 2020

Proteome analysis of glycoforms: a review of strategies for the microcharacterisation of glycoproteins separated by two-dimensional polyacrylamide gel electrophoresis.

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12 December 2020

Packed column supercritical fluid chromatography/mass spectrometry for high-throughput analysis. Part 2.

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12 December 2020

Identifying small-molecule lead compounds: the screening approach to drug discovery

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12 December 2020

Flow injection with chemical reaction interface-isotope ratio mass spectrometry: an alternative to off-line combustion for detecting low levels of enriched 13C in mass balance studies.

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12 December 2020

Characterization of tyrosine sulfate residues in antihemophilic recombinant factor VIII by liquid chromatography electrospray ionization tandem mass spectrometry and amino acid analysis

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12 December 2020

Micellar electrokinetic chromatography-mass spectrometry

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12 December 2020

Column switching in high-performance liquid chromatography with tandem mass spectrometric detection for high-throughput preclinical pharmacokinetic studies

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12 December 2020

Biomedical applications of accelerator mass spectrometry-isotope measurements at the level of the atom

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12 December 2020

The use of sequential high-performance liquid chromatography and capillary zone electrophoresis to separate the glycosylated peptides from recombinant tissue plasminogen activator to a detailed level of microheterogeneity

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12 December 2020

Identifying proteins and post-translational modifications by mass spectrometry.

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12 December 2020

A rotating ball inlet for on-line MALDI mass spectrometry

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12 December 2020

Reliable automatic protein identification from matrix-assisted laser desorption/ionization mass spectrometric peptide fingerprints

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12 December 2020

Peptide mass maps: a highly informative approach to protein identification

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12 December 2020

Affinity selection and mass spectrometry-based strategies to identify lead compounds in combinatorial libraries

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12 December 2020

The quadrupole ion trap mass spectrometer--a small solution to a big challenge.

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12 December 2020

High-speed screening of combinatorial libraries by gradient packed-column supercritical fluid chromatography

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12 December 2020

Rapid liquid chromatography with tandem mass spectrometry-based screening procedures for studies on the biotransformation of drug candidates

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12 December 2020

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags

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12 December 2020

Strategies for locating disulfide bonds in a monoclonal antibody via mass spectrometry

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12 December 2020

Pharmacokinetic and metabolism studies using uniformly stable isotope labeled proteins with HPLC/CRIMS detection

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12 December 2020

Formulation development and primary degradation pathways for recombinant human nerve growth factor.

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12 December 2020

The use of stable isotope labeling and liquid chromatography-tandem mass spectrometry techniques to simultaneously determine the oral and ophthalmic bioavailability of timolol in dogs

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12 December 2020

Off-line coupling of capillary electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

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12 December 2020

Analysis of hybridoma cell culture processes by SDS/gel capillary electrophoresis and matrix-assisted laser desorption ionization-time-of-flight MS.

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12 December 2020

Development of disulfide peptide mapping and determination of disulfide structure of recombinant human osteoprotegerin chimera produced in Escherichia coli

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12 December 2020

Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases

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12 December 2020

Identification of in vitro metabolites of Indinavir by "intelligent automated LC-MS/MS" (INTAMS) utilizing triple quadrupole tandem mass spectrometry.

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12 December 2020

Application of new analytical technology to the production of a "well-characterized biological".

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12 December 2020

Liquid chromatography/chemical reaction interface mass spectrometry as an alternative to radioisotopes for quantitative drug metabolism studies

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12 December 2020

Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons

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12 December 2020

High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation.

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12 December 2020

Characterization of benzodiazepine "combinatorial" chemical libraries by on-line immunoaffinity extraction, coupled column HPLC-ion spray mass spectrometry-tandem mass spectrometry

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12 December 2020

Rapid drug metabolite profiling using fast liquid chromatography, automated multiple-stage mass spectrometry and receptor-binding

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12 December 2020

Ionspray mass spectrometry of marine toxins. III. Analysis of paralytic shellfish poisoning toxins by flow-injection analysis, liquid chromatography/mass spectrometry and capillary electrophoresis/mass spectrometry

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12 December 2020

Structure elucidation of three isomeric metabolites of SYN-2836, a novel antifungal agent, in dogs via liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry methodologies.

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12 December 2020

The rapid identification of drug metabolites using capillary liquid chromatography coupled to an ion trap mass spectrometer

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12 December 2020

Susceptibility of rhDNase I to glycation in the dry-powder state.

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12 December 2020

High throughput liquid chromatography/mass spectrometric analyses using a novel multiplexed electrospray interface

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12 December 2020

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

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12 December 2020

Use of Caco-2 cells and LC/MS/MS to screen a peptide combinatorial library for permeable structures

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12 December 2020

Coupling capillary high-performance liquid chromatography to matrix-assisted laser desorption/ionization mass spectrometry and N-terminal sequencing of peptides via automated microblotting onto membrane substrates.

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12 December 2020

An integrated approach to proteome analysis: identification of proteins associated with cardiac hypertrophy

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12 December 2020

Consideration of conformational transitions and racemization during process development of recombinant glucagon-like peptide-1.

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12 December 2020

High-precision continuous-flow isotope ratio mass spectrometry

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12 December 2020

Determination of Pranlukast and its metabolites in human plasma by LC/MS/MS with PROSPEKT on-line solid-phase extraction

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12 December 2020

High throughput purification of combinatorial libraries

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12 December 2020

Mass spectrometry and the age of the proteome

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12 December 2020

Use of mass spectrometric molecular weight information to identify proteins in sequence databases

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12 December 2020

Identifiers

DOI

10.1023/A:1011049231231

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28 June 2017

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PubMed ID

11405282