(Q31141832)

29 June 2017

title

Discovering potent and selective reversible inhibitors of enzymes in complex proteomes (English)

1 reference

29 June 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12740587

1 January 2024

biomedical engineering

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1 January 2024

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Applied Microbiology and Biotechnology

1 January 2024

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1 January 2024

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4

Benjamin F Cravatt

1 reference

29 June 2017

Donmienne Leung

1

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29 June 2017

Christophe Hardouin

series ordinal

2

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29 June 2017

Dale L. Boger

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12740587

1 January 2024

Benjamin F. Cravatt

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12740587

1 January 2024

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12740587

1 January 2024

publication date

12 May 2003

1 reference

full work available at URL

29 June 2017

http://www.nature.com/articles/nbt826.pdf

file format

Portable Document Format

1 reference

http://www.nature.com/articles/nbt826

1 January 2024

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1 January 2024

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29 June 2017

volume

21

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29 June 2017

issue

6

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29 June 2017

page(s)

687-691

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Combinatorial strategies for targeting protein families: application to the proteases

29 June 2017

cites work

1 reference

7 January 2021

Parallel array and mixture-based synthetic combinatorial chemistry: tools for the next millennium

1 reference

7 January 2021

Technological advances in high-throughput screening

1 reference

7 January 2021

Activity-based protein profiling: the serine hydrolases

1 reference

7 January 2021

Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes

1 reference

7 January 2021

Profiling serine hydrolase activities in complex proteomes

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7 January 2021

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

1 reference

7 January 2021

Chemical strategies for functional proteomics

1 reference

7 January 2021

Chemical approaches for functionally probing the proteome

1 reference

7 January 2021

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design

1 reference

7 January 2021

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

1 reference

7 January 2021

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

1 reference

7 January 2021

Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition

1 reference

7 January 2021

Complex of alpha-chymotrypsin and N-acetyl-L-leucyl-L-phenylalanyl trifluoromethyl ketone: structural studies with NMR spectroscopy

1 reference

7 January 2021

NMR structural studies of the tight complex between a trifluoromethyl ketone inhibitor and the 85-kDa human phospholipase A2

1 reference

7 January 2021

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

1 reference

7 January 2021

Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site

1 reference

7 January 2021

Cluster analysis and display of genome-wide expression patterns

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7 January 2021

Profiling the specific reactivity of the proteome with non-directed activity-based probes

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7 January 2021

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

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7 January 2021

Modulation of anxiety through blockade of anandamide hydrolysis

1 reference

7 January 2021

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

1 reference

7 January 2021

Protease inhibitors: current status and future prospects

1 reference

7 January 2021

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

1 reference

7 January 2021

Identifiers

DOI

10.1038/NBT826

1 reference

Dimensions Publication ID

29 June 2017

1008350278

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