(Q31162696)

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Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute [...]

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11 January 2020

Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance (English)

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11 January 2020

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phosphorylation

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based on heuristic

inferred from title

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based on heuristic

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Michael J. Quon

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11 January 2020

Maureen A. Harrington

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Maureen A Harrington

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11 January 2020

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Jeong-a Kim

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11 January 2020

Deborah C Yeh

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11 January 2020

Marel Ver

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11 January 2020

Yunhua Li

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11 January 2020

Andrea Carranza

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11 January 2020

Thomas P Conrads

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11 January 2020

Timothy D Veenstra

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22 April 2005

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11 January 2020

Journal of Biological Chemistry

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11 January 2020

280

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11 January 2020

23173-23183

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11 January 2020

24

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11 January 2020

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Obesity is associated with macrophage accumulation in adipose tissue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Tumor necrosis factor alpha: a key component of the obesity-diabetes link

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

A central role for JNK in obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Insulin signalling: metabolic pathways and mechanisms for specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Tumor necrosis factor-alpha- and hyperglycemia-induced insulin resistance. Evidence for different mechanisms and different effects on insulin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Micrococci and peptidoglycan activate TLR2-->MyD88-->IRAK-->TRAF-->NIK-->IKK-->NF-kappaB signal transduction pathway that induces transcription of interleukin-8

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Modulation of tumor necrosis factor and interleukin-1-dependent NF-kappaB activity by mPLK/IRAK.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-κB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Developmental and tissue-specific expression of mouse pelle-like protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Transfection of DNA into isolated rat adipose cells by electroporation: evaluation of promoter activity in transfected adipose cells which are highly responsive to insulin after one day in culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Regulation of interleukin receptor-associated kinase (IRAK) phosphorylation and signaling by iota protein kinase C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

The insulin receptor substrate (IRS)-1 pleckstrin homology domain functions in downstream signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Heterologous pleckstrin homology domains do not couple IRS-1 to the insulin receptor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Insulin receptor substrate-1 pleckstrin homology and phosphotyrosine-binding domains are both involved in plasma membrane targeting

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

IRS pleckstrin homology domains bind to acidic motifs in proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Role of pleckstrin homology domain in regulating membrane targeting and metabolic function of insulin receptor substrate 3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Engineering the phosphoinositide-binding profile of a class I pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Structure and Dynamics of the Phospholipase C-δ1 Pleckstrin Homology Domain Located at the Lipid Bilayer Surface

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

The role of the PH domain in the signal-dependent membrane targeting of Sos.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor alpha (TNFalpha)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501439200

21 January 2018

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10.1074/JBC.M501439200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15849359%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15849359%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

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