(Q32058433)

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Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry

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scholarly article

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Europe PubMed Central

6 July 2017

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry (English)

1 reference

Europe PubMed Central

6 July 2017

electrophoresis

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author name string

Qiu Y

1

1 reference

Europe PubMed Central

6 July 2017

Benet LZ

2

1 reference

Europe PubMed Central

6 July 2017

Burlingame AL

3

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Europe PubMed Central

6 July 2017

language of work or name

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publication date

1 July 1998

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Europe PubMed Central

6 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

6 July 2017

273

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Europe PubMed Central

6 July 2017

17940-17953

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Europe PubMed Central

6 July 2017

28

1 reference

Europe PubMed Central

6 July 2017

Cytochrome P-450 isozyme selectivity in the oxidation of acetaminophen.

1 reference

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21 January 2018

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

1 reference

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21 January 2018

Cytotoxic effects of N-acetyl-p-benzoquinone imine, a common arylating intermediate of paracetamol and N-hydroxyparacetamol

1 reference

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21 January 2018

Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism

1 reference

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21 January 2018

Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.

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21 January 2018

Immunochemical analysis of acetaminophen covalent binding to proteins. Partial characterization of the major acetaminophen-binding liver proteins

1 reference

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21 January 2018

Purification, antibody production, and partial amino acid sequence of the 58-kDa acetaminophen-binding liver proteins

1 reference

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21 January 2018

A metabolite of acetaminophen covalently binds to the 56 kDa selenium binding protein

1 reference

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21 January 2018

Identification of the mouse liver 44-kDa acetaminophen-binding protein as a subunit of glutamine synthetase.

1 reference

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21 January 2018

Improvement of the solubilization of proteins in two-dimensional electrophoresis with immobilized pH gradients

1 reference

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21 January 2018

In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis

1 reference

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21 January 2018

Mass spectrometric and Edman sequencing of lipocortin I isolated by two-dimensional SDS/PAGE of human melanoma lysates

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21 January 2018

Twenty years of two-dimensional electrophoresis: past, present and future

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21 January 2018

Rapid mass spectrometric peptide sequencing and mass matching for characterization of human melanoma proteins isolated by two-dimensional PAGE.

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21 January 2018

Complementary DNA sequencing: expressed sequence tags and human genome project

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21 January 2018

Different patterns of regulation of the genes encoding the closely related 56 kDa selenium- and acetaminophen-binding proteins in normal tissues and during carcinogenesis

1 reference

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21 January 2018

Isolation, characterization, and chromosomal mapping of a novel cDNA clone encoding human selenium binding protein

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21 January 2018

Brief history of chemical carcinogenesis.

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21 January 2018

The role of metabolic activation in drug toxicity

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21 January 2018

Molecular mechanisms of the hepatotoxicity caused by acetaminophen

1 reference

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21 January 2018

Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention

1 reference

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21 January 2018

Specific targets of covalent drug-protein interactions in hepatocytes and their toxicological significance in drug-induced liver injury

1 reference

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21 January 2018

Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury.

1 reference

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21 January 2018

Identification of cytokine-regulated proteins in normal and malignant cells by the combination of two-dimensional polyacrylamide gel electrophoresis, mass spectrometry, Edman degradation and immunoblotting and approaches to the analysis of their fun

1 reference

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21 January 2018

Immobilized pH gradient two-dimensional gel electrophoresis and mass spectrometric identification of cytokine-regulated proteins in ME-180 cervical carcinoma cells

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21 January 2018

Isoelectric focusing in immobilized pH gradients: recent analytical and preparative developments

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21 January 2018

Urate oxidase: primary structure and evolutionary implications

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21 January 2018

Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels

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21 January 2018

Peptide sequence determination by matrix-assisted laser desorption ionization employing a tandem double focusing magnetic-Orthogonal acceleration time-of-flight mass spectrometer

1 reference

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21 January 2018

Two-dimensional electrophoresis of membrane proteins: a current challenge for immobilized pH gradients

1 reference

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21 January 2018

N-acetyl-p-benzoquinone imine-induced changes in the energy metabolism in hepatocytes.

1 reference

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21 January 2018

Mitochondrial dysfunction in paracetamol hepatotoxicity: in vitro studies in isolated mouse hepatocytes

1 reference

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21 January 2018

In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria

1 reference

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21 January 2018

The toxicological relevance of paracetamol-induced inhibition of hepatic respiration and ATP depletion

1 reference

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21 January 2018

Reversible and irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI).

1 reference

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21 January 2018

Impaired mitochondrial oxidative energy metabolism following paracetamol-induced hepatotoxicity in the rat.

1 reference

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21 January 2018

Selective alterations in the patterns of newly synthesized proteins by acetaminophen and its dimethylated analogues in primary cultures of mouse hepatocytes

1 reference

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21 January 2018

Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties

1 reference

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21 January 2018

Alpha,beta-unsaturated carbonyl compounds: inhibition of rat liver glutathione S-transferase isozymes and chemical reaction with reduced glutathione

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21 January 2018

Activation of the microsomal glutathione S-transferase by metabolites of alpha-methyldopa

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21 January 2018

Purification, mass spectrometric characterization, and covalent modification of murine glutathione S-transferases.

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21 January 2018

Acetaminophen hepatotoxicity: correspondence of selective protein arylation in human and mouse liver in vitro, in culture, and in vivo

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21 January 2018

Modulation of macrophage functioning abrogates the acute hepatotoxicity of acetaminophen.

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21 January 2018

The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution

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21 January 2018

Superoxide dismutase and catalase protect cultured hepatocytes from the cytotoxicity of acetaminophen.

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21 January 2018

Three models of free radical-induced cell injury

1 reference

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21 January 2018

The role of covalent binding to microsomal proteins in the hepatotoxicity of acetaminophen.

1 reference

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21 January 2018

Identifiers

10.1074/JBC.273.28.17940

1 reference

Europe PubMed Central

6 July 2017

1 reference

Europe PubMed Central

6 July 2017

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