(Q33197915)

English

Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.

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scholarly article

1 reference

Europe PubMed Central

23 July 2017

Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. (English)

1 reference

Europe PubMed Central

23 July 2017

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phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Wesley D Block

1

1 reference

Europe PubMed Central

23 July 2017

Yaping Yu

2

1 reference

Europe PubMed Central

23 July 2017

Susan P Lees-Miller

3

1 reference

Europe PubMed Central

23 July 2017

language of work or name

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publication date

10 February 2004

1 reference

Europe PubMed Central

23 July 2017

Nucleic Acids Research

1 reference

Europe PubMed Central

23 July 2017

32

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Europe PubMed Central

23 July 2017

997-1005

1 reference

Europe PubMed Central

23 July 2017

3

1 reference

Europe PubMed Central

23 July 2017

Repair of DNA double strand breaks by non-homologous end joining

1 reference

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The role of ATM and ATR in DNA damage-induced cell cycle control

1 reference

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Mechanism and regulation of human non-homologous DNA end-joining

1 reference

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28 July 2018

The phosphorylation domain of the 32-kDa subunit of replication protein A (RPA) modulates RPA-DNA interactions. Evidence for an intersubunit interaction

1 reference

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Checkpoint signaling: epigenetic events sound the DNA strand-breaks alarm to the ATM protein kinase

1 reference

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ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Apoptosis induced by topoisomerase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

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RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

BRCA1 modulates ionizing radiation-induced nuclear focus formation by the replication protein A p34 subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Purification and characterization of ATM from human placenta. A manganese-dependent, wortmannin-sensitive serine/threonine protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Complementation of the radiosensitive M059J cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Roles of replication protein A and DNA-dependent protein kinase in the regulation of DNA replication following DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Phosphorylation of replication protein A middle subunit (RPA32) leads to a disassembly of the RPA heterotrimer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Characterization of ATM expression, localization, and associated DNA-dependent protein kinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Ataxia-telangiectasia and the Nijmegen breakage syndrome: related disorders but genes apart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Mapping of amino acid residues in the p34 subunit of human single-stranded DNA-binding protein phosphorylated by DNA-dependent protein kinase and Cdc2 kinase in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Ionizing radiation-induced phosphorylation of RPA p34 is deficient in ataxia telangiectasia and reduced in aged normal fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Proteolytic mapping of human replication protein A: evidence for multiple structural domains and a conformational change upon interaction with single-stranded DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

DNA unwinding by replication protein A is a property of the 70 kDa subunit and is facilitated by phosphorylation of the 32 kDa subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

Recombinant replication protein A: expression, complex formation, and functional characterization

1 reference

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Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase

1 reference

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Radiation-induced DNA damage and repair in cells of a radiosensitive human malignant glioma cell line

1 reference

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28 July 2018

Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

28 July 2018

cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication

1 reference

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28 July 2018

The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX.

1 reference

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31 October 2018

Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

31 October 2018

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

31 October 2018

ATM and related protein kinases: safeguarding genome integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

31 October 2018

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

31 October 2018

Replication protein A2 phosphorylation after DNA damage by the coordinated action of ataxia telangiectasia-mutated and DNA-dependent protein kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

31 October 2018

Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

31 October 2018

UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

31 October 2018

Post-translational modifications and activation of p53 by genotoxic stresses

1 reference

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31 October 2018

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

31 October 2018

Conversion of topoisomerase I cleavage complexes on the leading strand of ribosomal DNA into 5'-phosphorylated DNA double-strand breaks by replication runoff

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

31 October 2018

Adozelesin triggers DNA damage response pathways and arrests SV40 DNA replication through replication protein A inactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373400

31 October 2018

The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells

1 reference

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31 October 2018

The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication

1 reference

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31 October 2018

Induction of DNA damage responses by adozelesin is S phase-specific and dependent on active replication forks

1 reference

https://pubmed.ncbi.nlm.nih.gov/14872059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons

1 reference

https://pubmed.ncbi.nlm.nih.gov/14872059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta

1 reference

https://pubmed.ncbi.nlm.nih.gov/14872059

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/NAR/GKH265

1 reference

Europe PubMed Central

23 July 2017

1 reference

Europe PubMed Central

23 July 2017

1 reference

Europe PubMed Central

23 July 2017

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