(Q33234000)

24 July 2017

title

Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors (English)

1 reference

24 July 2017

Chengxin Zhi

1

1 reference

24 July 2017

Zheng-Yu Long

2

1 reference

24 July 2017

Andrzej Manikowski

3

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24 July 2017

Jeanne Comstock

4

1 reference

24 July 2017

Wei-Chu Xu

5

1 reference

24 July 2017

Neal C Brown

6

1 reference

24 July 2017

Paul M Tarantino

7

1 reference

24 July 2017

Karsten A Holm

8

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24 July 2017

Edward J Dix

9

1 reference

24 July 2017

George E Wright

10

1 reference

24 July 2017

Marjorie H Barnes

11

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24 July 2017

Michelle M Butler

12

1 reference

24 July 2017

Kimberly A Foster

13

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24 July 2017

William A LaMarr

14

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24 July 2017

Benoit Bachand

15

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24 July 2017

Richard Bethell

16

1 reference

24 July 2017

Caroline Cadilhac

17

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24 July 2017

Sylvie Charron

18

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24 July 2017

Serge Lamothe

19

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24 July 2017

Irina Motorina

20

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24 July 2017

Richard Storer

21

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24 July 2017

language of work or name

English

0 references

publication date

1 February 2006

1 reference

Journal of Medicinal Chemistry

24 July 2017

published in

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24 July 2017

volume

49

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24 July 2017

issue

4

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24 July 2017

page(s)

1455-1465

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Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound

24 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Biological characterization of novel inhibitors of the gram-positive DNA polymerase IIIC enzyme

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Inhibitors of DNA polymerase III as novel antimicrobial agents against gram-positive eubacteria

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Fluoroquinolone toxicity profiles: a review focusing on newer agents

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Dual-action antibiotic hybrids

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Ciprofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Biotransformation of selected gyrase inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

1-Substituted 7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8- difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids. New quantitative structure-activity relationships at N1 for the quinolone antibacterials.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Structure-activity relationships of the fluoroquinolones

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Bacillus subtilis DNA polymerase III: complete sequence, overexpression, and characterization of the polC gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Synthesis, antibacterial activities, and pharmacological properties of enantiomers of temafloxacin hydrochloride

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Inhibition of Bacillus subtilis DNA polymerase III by arylhydrazinopyrimidines. Novel properties of 2-thiouracil derivatives

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Antibody to B. subtilis DNA polymerase III: use in enzyme purification and examination of homology among replication-specific DNA polymerases

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and Gram-positive bacterial growth

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

DNA gyrase and DNA topoisomerase of Bacillus subtilis: expression and characterization of recombinant enzymes encoded by the gyrA, gyrB and parC, parE genes.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Glycosylation of fluoroquinolones through direct and oxygenated polymethylene linkages as a sugar-mediated active transport system for antimicrobials

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2566945

Quantitative structure-activity relationships of antibacterial agents, 7-heterocyclic amine substituted 1-cyclopropyl-6,8-difluoro-4-oxoquinoline-3-carboxylic acids

31 October 2018

1 reference

12 December 2020

6-Anilinouracil-based inhibitors of Bacillus subtilis DNA polymerase III: antipolymerase and antimicrobial structure-activity relationships based on substitution at uracil N3

1 reference

12 December 2020

Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids

1 reference

12 December 2020

Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM0510023

1 reference

24 July 2017

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24 July 2017

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