(Q33273825)

25 July 2017

Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I. (English)

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25 July 2017

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Ern Loh

1

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25 July 2017

Juno Choe

series ordinal

2

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25 July 2017

Lawrence A Loeb

series ordinal

3

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25 July 2017

language of work or name

English

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publication date

14 February 2007

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Journal of Biological Chemistry

25 July 2017

9

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based on heuristic

inferred from page(s)

published in

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25 July 2017

282

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25 July 2017

12201-12209

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25 July 2017

16

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Enzymic synthesis of deoxyribonucleic acid

25 July 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Eukaryotic DNA polymerases: proposal for a revised nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Low fidelity DNA synthesis by human DNA polymerase-eta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Structural Insights into the Origins of DNA Polymerase Fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Error-Prone DNA Polymerases: When Making a Mistake is the Only Way to Get Ahead

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Eukaryotic DNA Polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

21 January 2018

DNA replication fidelity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

A mutant of DNA polymerase I (Klenow fragment) with reduced fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Mutants affecting nucleotide recognition by T7 DNA polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Enhanced fidelity in mismatch extension by DNA polymerase through directed combinatorial enzyme design

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

The conserved active site motif A of Escherichia coli DNA polymerase I is highly mutable

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

In vivo mutagenesis by Escherichia coli DNA polymerase I. Ile(709) in motif A functions in base selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

A single highly mutable catalytic site amino acid is critical for DNA polymerase fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Protein tolerance to random amino acid change

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Base-calling of automated sequencer traces using phred. I. Accuracy assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Toward Automatic Reconstruction of a Highly Resolved Tree of Life

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Compilation, alignment, and phylogenetic relationships of DNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Targeted gene evolution in Escherichia coli using a highly error-prone DNA polymerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Analyzing fidelity of DNA polymerases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Genetic and crystallographic studies of the 3',5'-exonucleolytic site of DNA polymerase I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Overproduction of DnaE protein (alpha subunit of DNA polymerase III) restores viability in a conditionally inviable Escherichia coli strain deficient in DNA polymerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

DNA polymerase active site is highly mutable: evolutionary consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Probing the active site tightness of DNA polymerase in subangstrom increments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Processive DNA synthesis observed in a polymerase crystal suggests a mechanism for the prevention of frameshift mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

DNA polymerase fidelity: kinetics, structure, and checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Kinetic Proofreading: A New Mechanism for Reducing Errors in Biosynthetic Processes Requiring High Specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Genetic studies of the lac repressor. XIV. Analysis of 4000 altered Escherichia coli lac repressors reveals essential and non-essential residues, as well as "spacers" which do not require a specific sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

An attempt to unify the structure of polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Prokaryotic DNA polymerase I: evolution, structure, and "base flipping" mechanism for nucleotide selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Designed divergent evolution of enzyme function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Presence of 18-A long hydrogen bond track in the active site of Escherichia coli DNA polymerase I (Klenow fragment). Its requirement in the stabilization of enzyme-template-primer complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Multiple mutations and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

Structure of DNA polymerase I Klenow fragment bound to duplex DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M611294200

21 January 2018

Identifiers

DOI

10.1074/JBC.M611294200

1 reference

25 July 2017

1 reference