(Q33520113)

27 July 2017

title

Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway (English)

1 reference

27 July 2017

Shreyas Das

1

1 reference

27 July 2017

Bryan N Becker

series ordinal

2

1 reference

27 July 2017

F Michael Hoffmann

series ordinal

3

1 reference

27 July 2017

Janet E Mertz

series ordinal

4

1 reference

27 July 2017

publication date

21 December 2009

1 reference

27 July 2017

1 reference

27 July 2017

volume

10

1 reference

27 July 2017

page(s)

94

1 reference

Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells

27 July 2017

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21 June 2018

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Delta-crystallin enhancer binding factor 1 controls the epithelial to mesenchymal transition phenotype and resistance to the epidermal growth factor receptor inhibitor erlotinib in human head and neck squamous cell carcinoma lines

21 June 2018

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21 June 2018

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Transcriptional regulation of cell polarity in EMT and cancer

21 June 2018

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21 June 2018

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21 June 2018

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HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition

21 June 2018

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A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition

21 June 2018

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21 June 2018

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Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis

21 June 2018

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Expression of the ZEB1 (deltaEF1) transcription factor in human: additional insights

21 June 2018

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The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2

21 June 2018

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The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

21 June 2018

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Zeb1 links epithelial-mesenchymal transition and cellular senescence

21 June 2018

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The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy

21 June 2018

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Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

21 June 2018

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Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

21 June 2018

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Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies

21 June 2018

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Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2.

21 June 2018

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Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment.

21 June 2018

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Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition

21 June 2018

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Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.

21 June 2018

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DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation

21 June 2018

1 reference

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Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA

21 June 2018

1 reference

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Matrix metalloproteinases and cellular motility in development and disease.

21 June 2018

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Regulation of Par6 by extracellular signals

21 June 2018

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A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.

21 June 2018

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

21 June 2018

1 reference

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TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation

21 June 2018

1 reference

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Development of TGF-beta signalling inhibitors for cancer therapy

21 June 2018

1 reference

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Activation of the Erk pathway is required for TGF-beta1-induced EMT in vitro

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression

21 June 2018

1 reference

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New insights into TGF-beta-Smad signalling

21 June 2018

1 reference

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Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition.

21 June 2018

1 reference

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Linking TGF-beta-mediated Cdc25A inhibition and cytoskeletal regulation through RhoA/p160(ROCK) signaling.

21 June 2018

1 reference

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Cell migration: Rho GTPases lead the way

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Epithelial-mesenchymal transitions in development and pathologies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Mechanisms, mechanics and function of epithelial-mesenchymal transitions in early development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Renal fibrosis. Extracellular matrix microenvironment regulates migratory behavior of activated tubular epithelial cells

21 June 2018

1 reference

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Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation

21 June 2018

1 reference

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TGF-beta1 is an autocrine mediator of renal tubular epithelial cell growth and collagen IV production

21 June 2018

1 reference

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 June 2018

1 reference

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Leaving the neighborhood: molecular mechanisms involved during epithelial-mesenchymal transition.

21 June 2018

1 reference

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The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Tubulointerstitial changes as a major determinant in the progression of renal damage

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

The microRNA-200 family regulates epithelial to mesenchymal transition.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Phase I clinical trial of a TGF-beta antisense-modified tumor cell vaccine in patients with advanced glioma

31 October 2018

1 reference

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Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Conditional gene targeting in the kidney

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Spatiotemporal regulation of morphogenetic molecules during in vitro branching of the isolated ureteric bud: toward a model of branching through budding in the developing kidney

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Reversal of experimental renal fibrosis by BMP7 provides insights into novel therapeutic strategies for chronic kidney disease

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2806300

Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20025777

12 December 2020

inferred from PubMed ID database lookup

The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20025777

12 December 2020

inferred from PubMed ID database lookup

Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20025777

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1186/1471-2121-10-94

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/iz5hhkfc3ncd7kprdvcfrkdto4

30 July 2022

Dimensions Publication ID

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-2121-10-94

release_iz5hhkfc3ncd7kprdvcfrkdto4

9 September 2019

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/iz5hhkfc3ncd7kprdvcfrkdto4

30 July 2022

https://api.fatcat.wiki/v0/release/iz5hhkfc3ncd7kprdvcfrkdto4

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/iz5hhkfc3ncd7kprdvcfrkdto4

1 reference

30 July 2022