(Q33543083)

27 July 2017

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title

Molecular chemotherapy for breast cancer (English)

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27 July 2017

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Patterson A

1

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PubMed ID

10084362

27 July 2017

Harris AL

series ordinal

2

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27 July 2017

1 February 1999

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27 July 2017

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27 July 2017

14

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27 July 2017

75-90

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27 July 2017

2

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https://scigraph.springernature.com/pub.10.2165/00002512-199914020-00001

27 July 2017

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cites work

Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression

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12 December 2020

Oxygen sensing and molecular adaptation to hypoxia

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12 December 2020

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.

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12 December 2020

Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069

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12 December 2020

Artificial P450/reductase fusion enzymes: what can we learn from their structures?

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12 December 2020

Gene therapy for cancer using tumour-specific prodrug activation.

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12 December 2020

The choice of prodrugs for gene directed enzyme prodrug therapy of cancer.

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12 December 2020

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy

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12 December 2020

Gene transfer using a novel fusion protein, GAL4/invasin

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12 December 2020

c-erbB-2 expression in benign and malignant breast disease

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12 December 2020

In vivo electrically mediated protein and gene transfer in murine melanoma

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12 December 2020

N-myc protein expression in human breast carcinoma: prognostic implications

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12 December 2020

High-level expression in Escherichia coli of enzymatically active fusion proteins containing the domains of mammalian cytochromes P450 and NADPH-P450 reductase flavoprotein

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12 December 2020

Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer

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12 December 2020

Localization of CEA messenger RNA by in situ hybridization in normal colonic mucosa and colorectal adenocarcinomas

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12 December 2020

Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer

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12 December 2020

c-erbB-2 protein expression in node negative breast cancer

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12 December 2020

Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group.

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12 December 2020

Enhancer sequences of the DF3 gene regulate expression of the herpes simplex virus thymidine kinase gene and confer sensitivity of human breast cancer cells to ganciclovir.

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12 December 2020

Partial regression, yet incomplete eradication of mammary tumors in transgenic mice by retrovirally mediated HSVtk transfer 'in vivo'.

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12 December 2020

MDA468 growth inhibition by EGF is associated with the induction of the cyclin-dependent kinase inhibitor p21WAF1.

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12 December 2020

Expression of the secretory leukoprotease inhibitor gene in epithelial cells

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12 December 2020

Acid pH in tumors and its potential for therapeutic exploitation

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12 December 2020

Induction of glucose-regulated proteins during anaerobic exposure and of heat-shock proteins after reoxygenation

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12 December 2020

Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage

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12 December 2020

Plateau-phase cultures: an experimental model for identifying drugs which are bioactivated within the microenvironment of solid tumours.

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12 December 2020

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12 December 2020

Molecular characterization of prostate-specific antigen messenger RNA expressed in breast tumors.

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12 December 2020

Gene therapy targeted by radiation preferentially radiosensitizes tumor cells.

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12 December 2020

A biological role for Egr-1 in cell survival following ultra-violet irradiation

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12 December 2020

CEA and NCA in benign and malignant breast tumors

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12 December 2020

Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir

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12 December 2020

Insulin-like growth factor II mRNA expression in human breast cancer

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12 December 2020

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

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12 December 2020

Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells

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12 December 2020

Transcriptional regulation of the carcinoembryonic antigen gene. Identification of regulatory elements and multiple nuclear factors

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12 December 2020

Investigation of alternative prodrugs for use with E. coli nitroreductase in 'suicide gene' approaches to cancer therapy.

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12 December 2020

Isolation of an X-ray-responsive element in the promoter region of tissue-type plasminogen activator: potential uses of X-ray-responsive elements for gene therapy.

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12 December 2020

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy

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12 December 2020

Regulation of p21WAF1/CIP1 expression by p53-independent pathways.

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12 December 2020

Analysis of C-myc messenger-RNA expression in primary breast carcinomas with clinical follow-up

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12 December 2020

Metabolic suicide genes in gene therapy

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12 December 2020

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy

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12 December 2020

Oxygen in human tumors: correlations between methods of measurement and response to therapy. Summary of a workshop held November 19-20, 1992, at the National Cancer Institute, Bethesda, Maryland.

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12 December 2020

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

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12 December 2020

Analysis of the tissue-specific promoter of the MUC1 gene.

1 reference

12 December 2020

Analysis of C-myc amplification by the differential polymerase chain-reaction (d-PCR), study in breast-cancer

1 reference

12 December 2020

Targeting gene expression to hypoxic tumor cells

1 reference

12 December 2020

Oxygen regulated 80 kDa protein and glucose regulated 78kDa protein are identical.

1 reference

12 December 2020

Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo

1 reference

12 December 2020

Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

1 reference

12 December 2020

Gene transfer technologies for the gene therapy of cancer.

1 reference

12 December 2020

Characterization of cis-acting elements regulating transcription of the human DF3 breast carcinoma-associated antigen (MUC1) gene

1 reference

12 December 2020

Immediate X-ray-inducible responses from mammalian cells.

1 reference

12 December 2020

HER-2/neu oncogene expression and proliferation in breast cancers

1 reference

12 December 2020

Recent developments in the design of bioreductive drugs

1 reference

12 December 2020

Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: correlation with steroid receptors

1 reference

12 December 2020

Carcinoembryonic antigen gene family: molecular biology and clinical perspectives

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12 December 2020

Mathematical modelling of oxygen supply and oxygenation in tumor tissues: Prognostic, therapeutic, and experimental implications

1 reference

12 December 2020

Multifactorial analysis of p53 alteration in human cancer: a review

1 reference

12 December 2020

The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

1 reference

12 December 2020

Tumor progression: potential role of unstable genomic changes

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12 December 2020

The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies

1 reference

12 December 2020

Overexpression of the c-erbB-2 protein in human breast tumor cell lines

1 reference

12 December 2020

Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer

1 reference

12 December 2020

Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins

1 reference

12 December 2020

Expression of the c-erbB2 gene in the BT474 human mammary tumor cell line: measurement of c-erbB2 mRNA half-life.

1 reference

12 December 2020

Defining a role for c-Myc in breast tumorigenesis.

1 reference

12 December 2020

The interaction of taxol and vinblastine with radiation induction of p53 and p21 WAF1/CIP1.

1 reference

12 December 2020

p53 protein expression in breast carcinomas. Comparative study with the wild type p53 induced proteins mdm2 and p21/waf1

1 reference

12 December 2020

Human prostate-specific antigen: structural and functional similarity with serine proteases

1 reference

12 December 2020

Sequence-specific DNA binding by the c-Myc protein

1 reference

12 December 2020

The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications

1 reference

12 December 2020

HER-2/neu, c-Myc and cyclin-A in human breast cancer

1 reference

12 December 2020

Prognostic significance of her-2/neu expression in breast cancer and its relationship to other prognostic factors

1 reference

12 December 2020

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1

1 reference

12 December 2020

Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

1 reference

12 December 2020

Use of the stress-inducible grp78/BiP promoter in targeting high level gene expression in fibrosarcoma in vivo.

1 reference

12 December 2020

Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells.

1 reference

12 December 2020

HER-2/neu amplification predicts poor survival in node-positive breast cancer

1 reference

12 December 2020

Spatial and temporal control of gene therapy using ionizing radiation

1 reference

12 December 2020

Absence of p21 expression is associated with abnormal p53 in human breast carcinomas

1 reference

12 December 2020

Strategy for achieving selective killing of carcinomas.

1 reference

12 December 2020

Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents

1 reference

12 December 2020

Egr-1 negatively regulates human tumor cell growth via the DNA-binding domain.

1 reference

12 December 2020

AP2 inhibits cancer cell growth and activates p21WAF1/CIP1 expression

1 reference

12 December 2020

Expression of c-myc proteins in breast cancer as related to established prognostic factors and survival

1 reference

12 December 2020

Induction of glucose regulated proteins during growth of a murine tumor

1 reference

12 December 2020

Characterization of monoclonal antibodies to carcinoembryonic antigen with increased tumor specificity.

1 reference

12 December 2020

Insulin-like growth factor receptor expression and function in human breast cancer

1 reference

12 December 2020

Expression of the cyclin-dependent kinase inhibitors p16INK4, p15INK4B and p21WAF1/CIP1 in human breast cancer

1 reference

12 December 2020

Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

1 reference

12 December 2020

Oxygen regulated gene expression: erythropoietin as a model system

1 reference

12 December 2020

The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy

1 reference

12 December 2020

Clinical and pathologic significance of the c-erbB-2 (HER-2/neu) oncogene

1 reference

12 December 2020

Drug sensitivity ("suicide") genes for selective cancer chemotherapy.

1 reference

12 December 2020

Insertion and extension of acyclic, dideoxy, and ara nucleotides by herpesviridae, human alpha and human beta polymerases. A unique inhibition mechanism for 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate

1 reference

12 December 2020

Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. In situ hybridization study and implication for a new in vivo functional model

1 reference

12 December 2020

In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.

1 reference

12 December 2020

Sensitization of human breast cancer cells to cyclophosphamide and ifosfamide by transfer of a liver cytochrome P450 gene.

1 reference

12 December 2020

Differential responsiveness of human breast cancer cell lines MCF-7 and T47D to growth factors and 17 beta-estradiol

1 reference

12 December 2020

p21/waf1/cip1 and mdm-2 expression in breast carcinoma patients as related to prognosis

1 reference

12 December 2020

Relationship between abnormal p53 protein and failure to express p21 protein in human breast carcinomas

1 reference

12 December 2020

p21(WAF1/CIP1) response to genotoxic agents in wild-type TP53 expressing breast primary tumours

1 reference

12 December 2020

p21(Waf1/Cip1) and p53 protein expression in breast cancer

1 reference

12 December 2020

Influence of c-myc on the progression of human breast cancer.

1 reference

12 December 2020

Basic fibroblast growth factor enhancement of adenovirus-mediated delivery of the herpes simplex virus thymidine kinase gene results in augmented therapeutic benefit in a murine model of ovarian cancer.

1 reference

12 December 2020

Antiprogestin inhibition of cell cycle progression in T-47D breast cancer cells is accompanied by induction of the cyclin-dependent kinase inhibitor p21.

1 reference

12 December 2020

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system

1 reference

12 December 2020

Gene therapy strategies for carcinoma of the breast

1 reference

12 December 2020

Use of targeted cationic liposomes in enhanced DNA delivery to cancer cells.

1 reference

12 December 2020

Architectural accommodation in the complex of four p53 DNA binding domain peptides with the p21/waf1/cip1 DNA response element

1 reference

12 December 2020

Carcinoembryonic antigen immunocytochemistry in primary breast cancer

1 reference

12 December 2020

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis

1 reference

12 December 2020

Preclinical studies and clinical correlation of the effect of alkylating dose.

1 reference

12 December 2020

Transcriptional regulatory sequences of carcinoembryonic antigen: identification and use with cytosine deaminase for tumor-specific gene therapy

1 reference

12 December 2020

Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter

1 reference

12 December 2020

Inhibition of tumor growth by direct intratumoral gene transfer of herpes simplex virus thymidine kinase gene with DNA-liposome complexes

1 reference

12 December 2020

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements

1 reference

12 December 2020

Immunoreactive prostate-specific antigen levels in female and male breast tumors and its association with steroid hormone receptors and patient age

1 reference

12 December 2020

Prostate-specific antigen promoter driven gene therapy targeting DNA polymerase-alpha and topoisomerase II alpha in prostate cancer.

1 reference

12 December 2020

Determinants of tumor blood flow: a review

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12 December 2020

TP53 and MYC gene alterations independently predict poor prognosis in breast cancer patients

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12 December 2020

DNA vaccination for cancer treatment.

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12 December 2020

The extent of heterocellular communication mediated by gap junctions is predictive of bystander tumor cytotoxicity in vitro

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12 December 2020

Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I

1 reference

12 December 2020

Genetic radiotherapy overcomes tumor resistance to cytotoxic agents.

1 reference

12 December 2020

Oncogene protein co-expression. Value of Ha-ras, c-myc, c-fos, and p53 as prognostic discriminants for breast carcinoma

1 reference

12 December 2020

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells

1 reference

12 December 2020

Prognostic value of erb-B2 and myc amplification in breast cancer imprints

1 reference

12 December 2020

Two GC boxes (Sp1 sites) are involved in regulation of the activity of the epithelium-specific MUC1 promoter.

1 reference

12 December 2020

Genetic alterations of c-myc, c-erbB-2, and c-Ha-ras protooncogenes and clinical associations in human breast carcinomas

1 reference

12 December 2020

Myc and Max proteins possess distinct transcriptional activities

1 reference

12 December 2020

Immunohistochemical c-erbB-2 protooncogene expression and nuclear DNA content in human mammary carcinoma in situ

1 reference

12 December 2020

C-ERBB-2 oncogens protein inIn situ and invasive lobular breast neoplasia

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12 December 2020

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

12 December 2020

Potentiation of cytochrome P450/cyclophosphamide-based cancer gene therapy by coexpression of the P450 reductase gene

1 reference

12 December 2020

The role of oxygen tension distribution on the radiation response of human breast carcinoma

1 reference

12 December 2020

Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines.

1 reference

12 December 2020

Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene.

1 reference

12 December 2020

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

1 reference

12 December 2020

Local regression of breast tumors following intramammary ganciclovir administration in double transgenic mice expressing neu oncogene and herpes simplex virus thymidine kinase

1 reference

12 December 2020

Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins

1 reference

12 December 2020

Ionizing radiation and teniposide increase p21(waf1/cip1) and promote Rb dephosphorylation but fail to suppress E2F activity in MCF-7 breast tumor cells

1 reference

12 December 2020

In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation

1 reference

12 December 2020

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer

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12 December 2020

Measuring Tumor Hypoxia

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12 December 2020

Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast Tumors

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12 December 2020

c-erbB-2 amplification in node-negative human breast cancer

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12 December 2020

Transcriptional regulation of DF3 gene expression in human MCF-7 breast carcinoma cells

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12 December 2020

Tissue specific promoters in targeting systemically delivered gene therapy.

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12 December 2020

Fluorouracil: biochemistry and pharmacology

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12 December 2020

Quantitation of HER-2/neu and c-myc gene amplification in breast carcinoma using fluorescence in situ hybridization

1 reference

12 December 2020

HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma

1 reference

12 December 2020

c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes

1 reference

12 December 2020

Definition of the expression of the human carcinoembryonic antigen and non-specific cross-reacting antigen in human breast and lung carcinomas

1 reference

12 December 2020

A novel transcription factor, OB2-1, is required for overexpression of the proto-oncogene c-erbB-2 in mammary tumour lines

1 reference

12 December 2020

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer

1 reference

12 December 2020

Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: correlation with serum prostate-specific antigen

1 reference

12 December 2020

Breast cancer selective gene expression and therapy mediated by recombinant adenoviruses containing the DF3/MUC1 promoter

1 reference

12 December 2020

Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity

1 reference

12 December 2020

Hypoxia and drug resistance

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12 December 2020

Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase

1 reference

12 December 2020

Multihormonal regulation of the progesterone receptor in MCF-7 human breast cancer cells: interrelationships among insulin/insulin-like growth factor-I, serum, and estrogen

1 reference

12 December 2020

Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo.

1 reference

12 December 2020

Studies on the rate-limiting enzyme component in the microsomal monooxygenase system. Incorporation of purified NADPH-cytochrome c reductase and cytochrome P-450 into rat liver microsomes

1 reference

12 December 2020

Detection of prostate-specific antigen immunoreactivity in breast tumors

1 reference

12 December 2020

Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy

1 reference

12 December 2020

Critical determination of the frequency of c-erbB-2 amplification in breast cancer

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12 December 2020

Prostate-specific antigen is a new favorable prognostic indicator for women with breast cancer.

1 reference

12 December 2020

Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours

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12 December 2020

Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma

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12 December 2020

Substrate-dependent competition of different P450 isozymes for limiting NADPH-cytochrome P450 reductase

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12 December 2020

Immunohistologic c-myc protein in benign breast disease and cancer.

1 reference

12 December 2020

Eradication of Myc-overexpressing small cell lung cancer cells transfected with herpes simplex virus thymidine kinase gene containing Myc-Max response elements

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12 December 2020

Clinical applications of carcinoembryonic antigen

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12 December 2020

c-myc amplification is a better prognostic factor than HER2/neu amplification in primary breast cancer

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12 December 2020

Characterization of the human L-plastin gene promoter in normal and neoplastic cells

1 reference

12 December 2020

Regulation of a hybrid gene by glucose and temperature in hamster fibroblasts.

1 reference

12 December 2020

Tissue distribution of antileukoprotease and lysozyme in humans.

1 reference

12 December 2020

Tumor hypoxia: its impact on cancer therapy

1 reference

12 December 2020

Prognostic value of p21(WAF1) and p53 expression in breast carcinoma: an immunohistochemical study in 261 patients with long-term follow-up.

1 reference

12 December 2020

10.2165/00002512-199914020-00001

Identifiers

DOI

1 reference

PubMed ID

10084362

Dimensions Publication ID

27 July 2017

0 references

1 reference

PubMed ID

10084362