(Q33583266)

28 July 2017

Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells (English)

1 reference

28 July 2017

N Suzuki

1

1 reference

28 July 2017

J Urano

series ordinal

2

1 reference

28 July 2017

F Tamanoi

series ordinal

3

1 reference

28 July 2017

language of work or name

English

0 references

publication date

1 December 1998

1 reference

Proceedings of the National Academy of Sciences of the United States of America

28 July 2017

1 reference

28 July 2017

95

1 reference

28 July 2017

15356-15361

1 reference

28 July 2017

26

1 reference

Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

28 July 2018

Caspases: enemies within

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

BCL-2 family: regulators of cell death

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Bax directly induces release of cytochrome c from isolated mitochondria

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Caspases and caspase inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Double identity for proteins of the Bcl-2 family

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Homozygous codeletion and differential decreased expression of p15INK4b, p16INK4a-alpha and p16INK4a-beta in mouse lung tumor cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Protein prenylation: molecular mechanisms and functional consequences

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

28 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

Apoptosis in the absence of cytochrome c accumulation in the cytosol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

Apoptosis by death factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

Advances in the development of farnesyltransferase inhibitors: substrate recognition by protein farnesyltransferase.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=28047

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

31 October 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

From bench top to bedside

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

Inhibition of growth factor-induced protein synthesis by a selective MEK inhibitor in aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

Intracellular K+ suppresses the activation of apoptosis in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.26.15356

The farnesyltransferase inhibitor, FPT inhibitor III upregulates Bax and Bcl-xs expression and induces apoptosis in human ovarian cancer cells

21 January 2018

1 reference

12 December 2020

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase

1 reference

12 December 2020

Persistence of cytochrome c binding to membranes at physiological mitochondrial intermembrane space ionic strength

1 reference

12 December 2020

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines

1 reference

12 December 2020

Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956

1 reference

12 December 2020

Involvement of caspase family proteases in FPT inhibitor III-induced apoptosis in human ovarian cancer cells

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.95.26.15356

1 reference

28 July 2017

0 references

1 reference

28 July 2017

1 reference