(Q33664107)

28 July 2017

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title

CD28/CTLA-4 and CD80/CD86 families: signaling and function (English)

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28 July 2017

J M Slavik

1

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28 July 2017

J E Hutchcroft

series ordinal

2

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28 July 2017

B E Bierer

series ordinal

3

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28 July 2017

1 January 1999

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28 July 2017

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28 July 2017

19

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28 July 2017

1-24

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28 July 2017

1

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https://scigraph.springernature.com/pub.10.1007/bf02786473

28 July 2017

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cites work

The role of the CD28 receptor during T cell responses to antigen

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

Evidence that a kinase distinct from protein kinase C and phosphatidylinositol 3-kinase mediates ligation-dependent serine/threonine phosphorylation of the T-lymphocyte co-stimulatory molecule CD28.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

How MAP kinases are regulated

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

CD28: a signalling perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

Signalling through CD28 T-cell activation pathway involves an inositol phospholipid-specific phospholipase C activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

CD28-mediated costimulation in the absence of phosphatidylinositol 3-kinase association and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

T-cell activation by the CD28 ligand B7 is required for cardiac allograft rejection in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02786473

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity.

21 January 2018

1 reference

12 December 2020

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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12 December 2020

CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice

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12 December 2020

Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation

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12 December 2020

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation

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12 December 2020

Absence of B7-dependent responses in CD28-deficient mice

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12 December 2020

CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the map kinases: ERK2 and Jun kinases

1 reference

12 December 2020

Activation of src family kinase lck following CD28 crosslinking in the Jurkat leukemic cell line

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12 December 2020

T cell antigen receptor signal transduction pathways

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12 December 2020

The T cell receptor/CD3 complex: a dynamic protein ensemble

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12 December 2020

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

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12 December 2020

Costimulation and autoimmunity

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12 December 2020

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor

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12 December 2020

Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

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12 December 2020

Interactions of CD80 and CD86 with CD28 and CTLA4

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12 December 2020

Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells

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12 December 2020

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells

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12 December 2020

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

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12 December 2020

Mitogen-activated protein kinase pathways

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12 December 2020

Treatment of murine lupus with CTLA4Ig

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12 December 2020

CD28 ligation in T-cell activation: evidence for two signal transduction pathways

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12 December 2020

CD28 signals through acidic sphingomyelinase

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12 December 2020

Comparison of CD28-B7.1 and B7.2 functional interaction in resting human T cells: phosphatidylinositol 3-kinase association to CD28 and cytokine production

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12 December 2020

Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses

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12 December 2020

B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

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12 December 2020

Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement

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12 December 2020

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2

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12 December 2020

Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling

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12 December 2020

Rho as a regulator of the cytoskeleton.

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12 December 2020

The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28

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12 December 2020

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity

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12 December 2020

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

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12 December 2020

IL-4 and IL-2 upregulate the expression of antigen B7, the B cell counterstructure to T cell CD28: an amplification mechanism for T-B cell interactions

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12 December 2020

CTLA-4 ligation blocks CD28-dependent T cell activation

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12 December 2020

CD28 co-stimulatory regimes differ in their dependence on phosphatidylinositol 3-kinase: common co-signals induced by CD80 and CD86

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12 December 2020

Signal transduction by CD28 costimulatory receptor on T cells. B7-1 and B7-2 regulation of tyrosine kinase adaptor molecules

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12 December 2020

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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12 December 2020

T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1.

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12 December 2020

Biased dependency of CD80 versus CD86 in the induction of transcription factors regulating the human IL-2 promoter.

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12 December 2020

Differential signaling by lymphocyte antigen receptors.

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12 December 2020

Multiple p21ras effector pathways regulate nuclear factor of activated T cells.

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12 December 2020

PLC gamma 1, a possible mediator of T cell receptor function

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12 December 2020

Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions

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12 December 2020

Cross-linking CD28 leads to activation of 70-kDa S6 kinase

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12 December 2020

Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis

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12 December 2020

Differential recognition by CD28 of its cognate counter receptors CD80 (B7.1) and B70 (B7.2): analysis by site directed mutagenesis

1 reference

12 December 2020

In search of a function for the Ras-like GTPase Rap1.

1 reference

12 December 2020

Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B.

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12 December 2020

The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.

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12 December 2020

CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase

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12 December 2020

CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line

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12 December 2020

Interleukin-10 inhibits B7 and intercellular adhesion molecule-1 expression on human monocytes

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12 December 2020

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse

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12 December 2020

The role of B7-1 and B7-2 costimulation for the generation of CTL responses in vivo.

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12 December 2020

Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4

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12 December 2020

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

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12 December 2020

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

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12 December 2020

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation

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12 December 2020

CD28-B7 interactions in T-cell activation.

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12 December 2020

The role of p21ras in CD28 signal transduction: triggering of CD28 with antibodies, but not the ligand B7-1, activates p21ras

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12 December 2020

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

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12 December 2020

Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin

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12 December 2020

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

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12 December 2020

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

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12 December 2020

Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice

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12 December 2020

T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras

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12 December 2020

Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production

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12 December 2020

IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.

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12 December 2020

Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg

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12 December 2020

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression

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12 December 2020

Two distinct intracytoplasmic regions of the T-cell adhesion molecule CD28 participate in phosphatidylinositol 3-kinase association

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12 December 2020

A novel protein-tyrosine kinase, tec, is preferentially expressed in liver

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12 December 2020

Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice

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12 December 2020

CTLA4 mediates antigen-specific apoptosis of human T cells

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12 December 2020

BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2

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12 December 2020

B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas

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12 December 2020

The mitogen-activated protein kinases, ERK1 and ERK2.

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12 December 2020

Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

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12 December 2020

Both CD28 ligands CD80 (B7-1) and CD86 (B7-2) activate phosphatidylinositol 3-kinase, and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion.

1 reference

12 December 2020

Coordinate transactivation of the interleukin-2 CD28 response element by c-Rel and ATF-1/CREB2.

1 reference

12 December 2020

Costimulation of tumor-reactive CD4+ and CD8+ T lymphocytes by B7, a natural ligand for CD28, can be used to treat established mouse melanoma

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12 December 2020

Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance

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12 December 2020

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1 reference

12 December 2020

Weak peptide agonists reveal functional differences in B7-1 and B7-2 costimulation of human T cell clones

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12 December 2020

The B7 and CD28 receptor families

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12 December 2020

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

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12 December 2020

Lymphocyte signalling: a coordinating role for Vav?

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12 December 2020

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

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12 December 2020

A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells

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12 December 2020

Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase

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12 December 2020

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6

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12 December 2020

Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy.

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12 December 2020

A cell culture model for T lymphocyte clonal anergy

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12 December 2020

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

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12 December 2020

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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12 December 2020

A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function

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12 December 2020

Signal transduction. How receptors turn Ras on.

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12 December 2020

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk

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12 December 2020

Rho family members: activators of MAP kinase cascades.

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12 December 2020

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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12 December 2020

Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells

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12 December 2020

CD28/B7 system of T cell costimulation

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12 December 2020

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production

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12 December 2020

Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal

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12 December 2020

Itk negatively regulates induction of T cell proliferation by CD28 costimulation

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12 December 2020

Regulation of surface and intracellular expression of CTLA4 on mouse T cells

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12 December 2020

B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells

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12 December 2020

CD28-mediated up-regulation of beta 1-integrin adhesion involves phosphatidylinositol 3-kinase.

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12 December 2020

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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12 December 2020

T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells

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12 December 2020

New perspectives of CD28-B7-mediated T cell costimulation

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12 December 2020

The role of tyrosine phosphorylation and PTP-1C in CTLA-4 signal transduction.

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12 December 2020

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

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12 December 2020

Signaling through CD28/CTLA-4 family receptors: puzzling participation of phosphatidylinositol-3 kinase

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12 December 2020

Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q

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12 December 2020

Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1

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12 December 2020

Parallel signal processing among mammalian MAPKs

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12 December 2020

The two-signal model of lymphocyte activation twenty-one years later

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12 December 2020

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

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12 December 2020

Sphingomyelin-ceramide turnover in CD28 costimulatory signaling

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12 December 2020

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

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12 December 2020

SH2 domains recognize specific phosphopeptide sequences

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12 December 2020

The BB1 monoclonal antibody recognizes both cell surface CD74 (MHC class II-associated invariant chain) as well as B7-1 (CD80), resolving the question regarding a third CD28/CTLA-4 counterreceptor

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12 December 2020

Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

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12 December 2020

B7-1 is superior to B7-2 costimulation in the induction and maintenance of T cell-mediated antileukemia immunity. Further evidence that B7-1 and B7-2 are functionally distinct

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12 December 2020

Differential T cell costimulatory requirements in CD28-deficient mice

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12 December 2020

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

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12 December 2020

CTLA-4 can function as a negative regulator of T cell activation

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12 December 2020

CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system

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12 December 2020

Stimulation through the TCR/CD3 complex up-regulates the CD2 surface expression on human T lymphocytes

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12 December 2020

Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production

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12 December 2020

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4.

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12 December 2020

CD28 receptor crosslinking induces tyrosine phosphorylation of PLC gamma 1

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12 December 2020

A new member of the immunoglobulin superfamily--CTLA-4

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12 December 2020

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

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12 December 2020

Differential down-regulation of CD28 by B7-1 and B7-2 engagement

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12 December 2020

Genetic and mutational analysis of the T-cell antigen receptor

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12 December 2020

B70 antigen is a second ligand for CTLA-4 and CD28.

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12 December 2020

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation

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12 December 2020

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

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12 December 2020

CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line

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12 December 2020

Subcellular localization of CD80 receptors is dependent on an intact cytoplasmic tail and is required for CD28-dependent T cell costimulation.

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12 December 2020

CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells

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12 December 2020

Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule

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12 December 2020

T cell receptor-associated alpha-phosphatidylinositol 3-kinase becomes activated by T cell receptor cross-linking and requires pp56lck

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12 December 2020

Signal transduction by lymphocyte antigen receptors

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12 December 2020

TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12

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12 December 2020

Costimulation of IL-4 production by murine B7-1 and B7-2 molecules

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12 December 2020

Identification of residues in the V domain of CD80 (B7-1) implicated in functional interactions with CD28 and CTLA4

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12 December 2020

T-cell antigen receptor ligation induces tyrosine phosphorylation of phospholipase C-gamma 1

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12 December 2020

Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins

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12 December 2020

PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface

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12 December 2020

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7

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12 December 2020

Two regions in the CD80 cytoplasmic tail regulate CD80 redistribution and T cell costimulation

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12 December 2020

The regulation and function of p21ras in T cells

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12 December 2020

Activation of p21-CDC42/Rac-activated kinases by CD28 signaling: p21-activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals

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12 December 2020

B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro

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12 December 2020

Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28

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12 December 2020

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function

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12 December 2020

Expression and functional significance of an additional ligand for CTLA-4.

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12 December 2020

Antigen receptor tail clue.

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12 December 2020

Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK.

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12 December 2020

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation

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12 December 2020

Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.

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12 December 2020

CD28 of T lymphocytes associates with phosphatidylinositol 3-kinase

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12 December 2020

Resting and anergic B cells are defective in CD28-dependent costimulation of naive CD4+ T cells.

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12 December 2020

Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion

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12 December 2020

CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL

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12 December 2020

JNK is involved in signal integration during costimulation of T lymphocytes.

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12 December 2020

Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C

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12 December 2020

Disulfide linkage of the zeta and eta chains of the T cell receptor. Possible identification of two structural classes of receptors.

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12 December 2020

Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

1 reference

12 December 2020

Regulation of beta 1-integrin-mediated cell adhesion by the Cbl adaptor protein.

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12 December 2020

T cell receptor/CD3 and CD28 use distinct intracellular signaling pathways

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12 December 2020

Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells

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12 December 2020

Ligation of the T cell receptor complex results in activation of the Ras/Raf-1/MEK/MAPK cascade in human T lymphocytes

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12 December 2020

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

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12 December 2020

Genomic organization and transcriptional regulation of the RANTES chemokine gene

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12 December 2020

Phosphatidylinositol 3-kinase

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12 December 2020

Blocked Ras activation in anergic CD4+ T cells

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12 December 2020

Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes

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12 December 2020

p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation

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12 December 2020

Characterization of the structure and function of a novel MAP kinase kinase (MKK6)

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12 December 2020

Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway.

1 reference

12 December 2020

Thymocyte development is normal in CTLA-4-deficient mice

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12 December 2020

Analysis of the site of interaction of CD28 with its counter-receptors CD80 and CD86 and correlation with function.

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12 December 2020

Identifiers

DOI

10.1007/BF02786473

1 reference

Dimensions Publication ID

28 July 2017

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