(Q33671995)

28 July 2017

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title

Clinical pharmacology of new histamine H1 receptor antagonists (English)

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28 July 2017

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Simons FE

1

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28 July 2017

Simons KJ

series ordinal

2

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28 July 2017

publication date

1 May 1999

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Clinical Pharmacokinetics

28 July 2017

published in

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28 July 2017

volume

36

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28 July 2017

issue

5

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28 July 2017

page(s)

329-352

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The inhibitory actions of azelastine hydrochloride on the early and late bronchoconstrictor responses to inhaled allergen in atopic asthma

28 July 2017

cites work

1 reference

12 December 2020

Pharmacokinetics and dose proportionality of loratadine

1 reference

12 December 2020

Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study

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12 December 2020

Pharmacokinetics of acrivastine after oral and colonic administration

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12 December 2020

Molecular properties and pharmacokinetic behavior of cetirizine, a zwitterionic H1-receptor antagonist

1 reference

12 December 2020

Lack of effect of mizolastine on the safety and pharmacokinetics of digoxin administered orally in repeated doses to healthy volunteers

1 reference

12 December 2020

Histamine blockade after astemizole in children: a single-dose, placebo-controlled study

1 reference

12 December 2020

Single-dose effect of astemizole on bronchoconstriction induced by histamine in asthmatic subjects

1 reference

12 December 2020

Intranasal Azelastine

1 reference

12 December 2020

The pharmacokinetic properties of topical levocabastine. A review

1 reference

12 December 2020

Lack of pharmacodynamic and pharmacokinetic interactions of the antihistamine ebastine with ethanol in healthy subjects

1 reference

12 December 2020

The pharmacokinetics of loratadine in normal geriatric volunteers

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12 December 2020

Cetirizine: a pharmacokinetic and pharmacodynamic evaluation in children with seasonal allergic rhinitis

1 reference

12 December 2020

Protection against histamine-induced bronchoconstriction by loratadine

1 reference

12 December 2020

Dose proportionality and comparison of single and multiple dose pharmacokinetics of fexofenadine (MDL 16455) and its enantiomers in healthy male volunteers

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12 December 2020

Plasma concentrations of astemizole in patients with terminal renal insufficiency, before, during and after hemodialysis

1 reference

12 December 2020

Duration of the effect of astemizole on histamine-inhalation tests

1 reference

12 December 2020

Loratadine administered concomitantly with erythromycin: pharmacokinetic and electrocardiographic evaluations

1 reference

12 December 2020

The eternal triangle: benefit, risk, and cost of therapeutic agents

1 reference

12 December 2020

Cardiac actions of antihistamines

1 reference

12 December 2020

Efficacy of azelastine in perennial allergic rhinitis: clinical and rhinomanometric evaluation

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12 December 2020

Parametrization by nonlinear regression analysis of the active acid metabolite of ebastine using different weighting methods

1 reference

12 December 2020

H1-receptor antagonists. Comparative tolerability and safety

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12 December 2020

Sensitive gas-liquid chromatographic method for the determination of loratadine and its major active metabolite, descarboethoxyloratadine, in human plasma using a nitrogen-phosphorus detector.

1 reference

12 December 2020

The effects of astemizole, cetirizine and loratadine on the time course of weal and flare reactions to histamine, codeine and antigen

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12 December 2020

Pharmacokinetic-pharmacodynamic relationships of H1-antihistamines

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12 December 2020

The in vivo potency and selectivity of azelastine as an H1 histamine-receptor antagonist in human airways and skin

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12 December 2020

Lack of subsensitivity to mizolastine over 8-week treatment

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12 December 2020

Studies of metabolic fate of a new antiallergic agent, azelastine (4-(p-chlorobenzyl)-2-[N-methylperhydroazepinyl-(4)]-1-(2H)-phthalazinone hydrochloride).

1 reference

12 December 2020

Detection and determination of free and plasma protein-bound astemizole by thin-layer chromatography: a useful technique for bioavailability studies

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12 December 2020

Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice

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12 December 2020

Quantitation of H1-receptor antagonists in skin and serum

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12 December 2020

N-Dealkylation and hydroxylation of ebastine by human liver cytochrome P450.

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12 December 2020

Comparative bioavailability of single doses of tablet formulations of cetirizine dihydrochloride in healthy male volunteers

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12 December 2020

Pharmacokinetic analysis of mizolastine in healthy young volunteers after single oral and intravenous doses: noncompartmental approach and compartmental modeling

1 reference

12 December 2020

Onset of action, efficacy, and safety of a single dose of fexofenadine hydrochloride for ragweed allergy using an environmental exposure unit

1 reference

12 December 2020

Pharmacodynamic and pharmacokinetics of BW 825C: a new antihistamine

1 reference

12 December 2020

Comparison of efficacy, safety, and skin test inhibition of cetirizine and astemizole

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12 December 2020

Lack of effect of erythromycin and ketoconazole on the pharmacokinetics and pharmacodynamics of steady-state intranasal levocabastine.

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12 December 2020

The pharmacology and use of H1-receptor-antagonist drugs

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12 December 2020

The effect of activated charcoal on the absorption and elimination of astemizole

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12 December 2020

Onset of action of astemizole

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12 December 2020

Inhibition of histamine-induced skin wheal and flare after 5 days of mizolastine

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12 December 2020

Lack of subsensitivity to loratadine during long-term dosing during 12 weeks

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12 December 2020

Single dose pharmacokinetics of cetirizine in young and elderly volunteers

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12 December 2020

Pharmacokinetics, pharmacodynamics, and tolerance of single- and multiple-dose fexofenadine hydrochloride in healthy male volunteers

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12 December 2020

High-performance thin-layer chromatography for the determination of cetirizine in human plasma and its use in pharmacokinetic studies

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12 December 2020

Determination of mizolastine, a new antihistaminic drug, in human plasma by liquid-liquid extraction, solid-phase extraction and column-switching techniques in combination with high-performance liquid chromatography

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12 December 2020

Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis.

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12 December 2020

Cetirizine. A reappraisal of its pharmacological properties and therapeutic use in selected allergic disorders

1 reference

12 December 2020

Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.

1 reference

12 December 2020

Effects of loratadine (SCH 29851) in suppression of histamine-induced skin wheals

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12 December 2020

Pharmacokinetics of Loratadine in Pediatric Subjects.

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12 December 2020

Suppression of histamine-induced wheal response by loratadine (SCH 29851) over 28 days in man.

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12 December 2020

Pharmacokinetics of loratadine and pseudoephedrine following single and multiple doses of once- versus twice-daily combination tablet formulations in healthy adult males.

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12 December 2020

Cimetidine does not influence the metabolism of the H1-receptor antagonist ebastine to its active metabolite carebastine.

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12 December 2020

Loratadine: multiple-dose pharmacokinetics.

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12 December 2020

The inhibitory effect of TMK688, a novel anti-allergic drug having both 5-lipoxygenase inhibitory activity and anti-histamine activity, against bronchoconstriction, leukotriene production and inflammatory cell infiltration in sensitized guinea pigs

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12 December 2020

Pharmacokinetics of astemizole in children

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12 December 2020

The effect of cetirizine and loratadine on codeine-induced histamine release in human skin in vivo assessed by cutaneous microdialysis

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12 December 2020

Cardiovascular safety of fexofenadine HCl.

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12 December 2020

A pharmacokinetic evaluation of the second-generation H1-receptor antagonist cetirizine in very young children

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12 December 2020

Pharmacokinetics of cetirizine in the elderly and patients with renal insufficiency

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12 December 2020

Mizolastine: antihistaminic activity from preclinical data to clinical evaluation

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12 December 2020

Pharmacokinetics of orally administered levocabastine in patients with renal insufficiency

1 reference

12 December 2020

Effect of cetirizine, a new histamine H1 antagonist, on airway dynamics and responsiveness to inhaled histamine in mild asthma

1 reference

12 December 2020

Pharmacological Modulation by Cetirizine and Ebastine of the Cutaneous Reactivity to Histamine

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12 December 2020

Efficacy and safety of fexofenadine hydrochloride for treatment of seasonal allergic rhinitis

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12 December 2020

Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders

1 reference

12 December 2020

Dose-response relationship of the H1-histamine antagonist, ebastine, against histamine and methacholine-induced bronchoconstriction in patients with asthma

1 reference

12 December 2020

Duration of effect of loratadine and terfenadine administered once a day for one week on cutaneous and inhaled reactivity to histamine

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12 December 2020

Comparison of the suppressive effect of astemizole, terfenadine, and hydroxyzine on histamine-induced wheals and flares in humans

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12 December 2020

Quantitative gas chromatographic-mass spectrometric analysis of acrivastine and a metabolite in human plasma

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12 December 2020

Comparison of the onset of H1-antagonism with acrivastine and terfenadine by histamine bronchial challenge in volunteers

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12 December 2020

Pharmacological modulation by cetirizine and loratadine of antigen and histamine-induced skin weals and flares, and late accumulation of eosinophils

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12 December 2020

Influence of itraconazole on the pharmacokinetics and electrocardiographic effects of astemizole

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12 December 2020

Effect of the H2-antagonist cimetidine on the pharmacokinetics and pharmacodynamics of the H1-antagonists hydroxyzine and cetirizine in patients with chronic urticaria

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12 December 2020

Steady-state pharmacokinetics and electrocardiographic pharmacodynamics of clarithromycin and loratadine after individual or concomitant administration

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12 December 2020

Ebastine. a review of its pharmacological properties and clinical efficacy in the treatment of allergic disorders

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12 December 2020

Tolerability and pharmacokinetics of single and multiple doses of azelastine hydrochloride in elderly volunteers.

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12 December 2020

Cetirizine Pharmacokinetics and Pharmacodynamics in Primary Biliary Cirrhosis

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12 December 2020

Effect of haemodialysis on the pharmacokinetics of cetirizine

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12 December 2020

Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever

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12 December 2020

Suppression of the skin reaction to histamine by ebastine

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12 December 2020

Topical azelastine has a 12-hour duration of action as assessed by histamine challenge-induced exudation of alpha 2-macroglobulin into human nasal airways

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12 December 2020

Determination of azelastine and desmethylazelastine in human plasma by high-performance liquid chromatography

1 reference

12 December 2020

Comparison of the effects of single doses of the new H1-receptor antagonists loratadine and terfenadine versus placebo in children

1 reference

12 December 2020

Pharmacodynamics and pharmacokinetics of mizolastine (SL 85.0324), a new nonsedative H1 antihistamine

1 reference

12 December 2020

The clinical pharmacology of fexofenadine in children

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12 December 2020

Effects of mizolastine, a new antihistamine, on psychomotor performance and memory in elderly subjects.

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12 December 2020

Peripheral H1-blockade effect of fexofenadine

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12 December 2020

Determination of loratadine and pheniramine from human serum by gas chromatography-mass spectrometry

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12 December 2020

Pharmacokinetics and pharmacodynamics of cetirizine in infants and toddlers

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12 December 2020

Suppression of histamine-induced skin reactions by loratadine and cetirizine diHCl.

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12 December 2020

Cetirizine inhibition of histamine-induced bronchospasm

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12 December 2020

Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance

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12 December 2020

Inhibiting effect of cetirizine on histamine-induced and 48/80-induced wheals and flares, experimental dermographism, and cold-induced urticaria

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12 December 2020

Mizolastine: a review of its use in allergic rhinitis and chronic idiopathic urticaria

1 reference

12 December 2020

Astemizole. A nonsedating antihistamine with fast and sustained activity

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12 December 2020

Pharmacokinetics of cetirizine in 2- to 6-year-old children

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12 December 2020

Tolerability, pharmacokinetics and dose linearity of azelastine hydrochloride in healthy subjects

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12 December 2020

A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects

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12 December 2020

Effect of azelastine on bronchoconstriction induced by histamine and leukotriene C4 in patients with extrinsic asthma

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12 December 2020

Lack of effect of azelastine and ketoconazole coadministration on electrocardiographic parameters in healthy volunteers.

1 reference

12 December 2020

Single-dose pharmacokinetics of cetirizine in patients with chronic liver disease

1 reference

12 December 2020

Levocabastine. A review of its pharmacological properties and therapeutic potential as a topical antihistamine in allergic rhinitis and conjunctivitis

1 reference

12 December 2020

Astemizole, a potent histamine H1-receptor antagonist: effect in allergic rhinoconjunctivitis, on antigen and histamine induced skin weal responses and relationship to serum levels

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12 December 2020

Pharmacokinetics of loratadine in patients with renal insufficiency

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12 December 2020

Gas chromatographic method for the determination of cetirizine in plasma

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12 December 2020

Excretion of loratadine in human breast milk

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12 December 2020

Effect of food on the bioavailability of fexofenadine hydrochloride (MDL 16455A).

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12 December 2020

Mechanism of the cardiotoxic actions of terfenadine

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12 December 2020

Azelastine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential

1 reference

12 December 2020

Cutaneous antihistaminic action of cetirizine and dose-related EEG concomitants of sedation in man

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12 December 2020

Plasma and skin suction-blister-fluid pharmacokinetics and time course of the effects of oral mizolastine

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12 December 2020

Comparison of the effect of loratadine on the airway and skin responses to histamine, methacholine, and allergen in subjects with asthma

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12 December 2020

Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine

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12 December 2020

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12 December 2020

Comparative wheal and flare study of mizolastine vs terfenadine, cetirizine, loratadine and placebo in healthy volunteers.

1 reference

12 December 2020

Time of onset of action of acrivastine in the skin of pollen-allergic subjects. A double-blind, randomized, placebo-controlled comparative study

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12 December 2020

Synthesis and pharmacology of combined histamine H1-/H2-receptor antagonists containing diphenhydramine and cyproheptadine derivatives.

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12 December 2020

Influence of food on the oral bioavailability of loratadine and pseudoephedrine from extended-release tablets in healthy volunteers

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12 December 2020

Loratadine. A reappraisal of its pharmacological properties and therapeutic use in allergic disorders

1 reference

12 December 2020

Population pharmacokinetic analysis of mizolastine and validation from sparse data on patients using the nonparametric maximum likelihood method

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12 December 2020

The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects

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12 December 2020

The comparative actions and adverse effect profile of single doses of H1-receptor antihistamines in the airways and skin of subjects with asthma

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12 December 2020

Initiation of the effects of acrivastine and cetirizine on histamine-induced wheals and itch in human skin

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12 December 2020

Pharmacokinetics and pharmacodynamics of ebastine in children

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12 December 2020

The metabolism and pharmacokinetics of 14C-cetirizine in humans

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12 December 2020

Spectrophotometric quantification of astemizole and its demethylated metabolite in urine after TLC separation

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12 December 2020

Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects.

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12 December 2020

Optically active analogues of ebastine: synthesis and effect of chirality on their antihistaminic and antimuscarinic activity

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12 December 2020

Intranasal azelastine. A review of its efficacy in the management of allergic rhinitis

1 reference

12 December 2020

10.2165/00003088-199936050-00003

Identifiers

DOI

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Dimensions Publication ID

28 July 2017

1053088486

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