(Q33702276)

28 July 2017

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title

Polymorphic human cytochrome P450 enzymes: an opportunity for individualized drug treatment (English)

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28 July 2017

Ingelman-Sundberg M

1

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28 July 2017

Oscarson M

series ordinal

2

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28 July 2017

McLellan RA

series ordinal

3

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28 July 2017

publication date

1 August 1999

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Trends in Pharmacological Sciences

28 July 2017

published in

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28 July 2017

volume

20

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28 July 2017

issue

8

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28 July 2017

page(s)

342-349

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Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985)

28 July 2017

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Modification of Clinical Presentation of Prostate Tumors by a Novel Genetic Variant in CYP3A4

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Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

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7 January 2021

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution

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Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

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7 January 2021

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

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Characterisation and PCR-based detection of a CYP2A6 gene deletion found at a high frequency in a Chinese population

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7 January 2021

Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase

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7 January 2021

A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished debrisoquine hydroxylase activity

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7 January 2021

The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase

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7 January 2021

Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms.

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7 January 2021

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

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7 January 2021

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Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP2D6 genes

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7 January 2021

Characterization of a Human GlutathioneS-Transferase μ Cluster Containing a DuplicatedGSTM1Gene that Causes Ultrarapid Enzyme Activity

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7 January 2021

Molecular basis for rational megaprescribing in ultrarapid hydroxylators of debrisoquine

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7 January 2021

10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes*

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7 January 2021

Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity

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7 January 2021

Quick Onset of Severe Abdominal Pain After Codeine in an Ultrarapid Metabolizer of Debrisoquine

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7 January 2021

Relationship between plasma desipramine levels, CYP2D6 phenotype and clinical response to desipramine: a prospective study

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7 January 2021

Disposition of fluvoxamine in humans is determined by the polymorphic CYP2D6 and also by the CYP1A2 activity

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7 January 2021

The disposition of fluoxetine but not sertraline is altered in poor metabolizers of debrisoquin

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7 January 2021

Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine

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7 January 2021

Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms

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7 January 2021

The CYP2D6 genotype predicts the oral clearance of the neuroleptic agents perphenazine and zuclopenthixol

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7 January 2021

Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine

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7 January 2021

Impaired oxidation of debrisoquine in patients with perhexiline neuropathy

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7 January 2021

The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine

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7 January 2021

Rapid determination of CYP2D6 phenotype during propafenone therapy by analysing urinary excretion of propafenone glucuronides

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7 January 2021

The cytochrome P450 2D6 (CYP2D6) enzyme polymorphism: screening costs and influence on clinical outcomes in psychiatry

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Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

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7 January 2021

Genetically deficient CYP2D6 metabolism provides protection against oral opiate dependence

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Effect of CYP2C19 polymorphism on serum levels of vitamin B12 in patients on long-term omeprazole treatment

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7 January 2021

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7 January 2021

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7 January 2021

Nicotine metabolism defect reduces smoking

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7 January 2021

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7 January 2021

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7 January 2021

Xenobiotic and endobiotic inhibitors of cytochrome P-450dbl function, the target of the debrisoquine/sparteine type polymorphism

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7 January 2021

Molecular cloning of a family of xenobiotic-inducible drosophilid cytochrome P450s: Evidence for involvement in host-plant allelochemical resistance

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7 January 2021

Involvement of cytochrome P450 in host-plant utilization by Sonoran Desert Drosophila

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Molecular heterogeneity at the CYP2D gene locus in Nicaraguans: impact of gene-flow from Europe

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7 January 2021

Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County

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7 January 2021

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Identifiers

DOI

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28 July 2017

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