(Q33716190)

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Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer

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Europe PubMed Central

28 July 2017

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Europe PubMed Central

Mechanism of protein kinase B activation by insulin/insulin-like growth factor-1 revealed by specific inhibitors of phosphoinositide 3-kinase--significance for diabetes and cancer (English)

1 reference

Europe PubMed Central

28 July 2017

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based on heuristic

inferred from title

5

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Europe PubMed Central

28 July 2017

6

object named as

Hemmings BA

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Europe PubMed Central

28 July 2017

author name string

Galetic I

1

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Europe PubMed Central

28 July 2017

Andjelkovic M

2

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Europe PubMed Central

28 July 2017

Meier R

3

1 reference

Europe PubMed Central

28 July 2017

Brodbeck D

4

1 reference

Europe PubMed Central

28 July 2017

publication date

1 May 1999

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Europe PubMed Central

28 July 2017

Pharmacology & Therapeutics

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Europe PubMed Central

28 July 2017

82

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Europe PubMed Central

28 July 2017

409-425

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Europe PubMed Central

28 July 2017

2-3

1 reference

Europe PubMed Central

28 July 2017

Phosphatidylinositol 3-kinase related kinases

1 reference

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7 January 2021

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inferred from DOI database lookup

Assessment of the roles of mitogen-activated protein kinase, phosphatidylinositol 3-kinase, protein kinase B, and protein kinase C in insulin inhibition of cAMP-induced phosphoenolpyruvate carboxykinase gene transcription

1 reference

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7 January 2021

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Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1 reference

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7 January 2021

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Mechanism of activation of protein kinase B by insulin and IGF-1

1 reference

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7 January 2021

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Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

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Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Role of translocation in the activation and function of protein kinase B

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Cell nonautonomy of C. elegans daf-2 function in the regulation of diapause and life span

1 reference

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7 January 2021

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

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7 January 2021

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Incidence of homogeneously staining regions in non-Hodgkin lymphomas

1 reference

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7 January 2021

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A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

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7 January 2021

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inferred from DOI database lookup

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

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7 January 2021

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inferred from DOI database lookup

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

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inferred from DOI database lookup

The activation of p38 and apoptosis by the inhibition of Erk is antagonized by the phosphoinositide 3-kinase/Akt pathway

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inositol trisphosphate and calcium signalling

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of threonine 638 critically controls the dephosphorylation and inactivation of protein kinase Calpha.

1 reference

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7 January 2021

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inferred from DOI database lookup

Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A signaling pathway to translational control

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin increases the association of Akt-2 with Glut4-containing vesicles

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Oncogenes and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

1 reference

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7 January 2021

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inferred from DOI database lookup

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factor-binding protein-1 gene expression through a conserved insulin response sequence

1 reference

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7 January 2021

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inferred from DOI database lookup

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

PI 3-kinase is a dual specificity enzyme: autoregulation by an intrinsic protein-serine kinase activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Signalling by receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The pleckstrin homology domain of phospholipase C-delta 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Functions of ceramide in coordinating cellular responses to stress

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Pleckstrin domain homology

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Dimerization of cell surface receptors in signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Akt signaling: linking membrane events to life and death decisions

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

PH domains--a universal membrane adapter

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

PtdIns(3,4,5)P3 gets its message across

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Tyrosine phosphorylation: past, present and future

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the binding site for inositol phosphates in a PH domain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific binding of the Akt-1 protein kinase to phosphatidylinositol 3,4,5-trisphosphate without subsequent activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning of a second form of rac protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of signal transduction and signal diversity by receptor oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction through MAP kinase cascades

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Life without the IRS

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the pleckstrin homology domain from beta-spectrin.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The riddle of MAP kinase signaling specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The TGF-beta family and its composite receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

A putative modular domain present in diverse signaling proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of p70/p85 S6 kinase by a pathway independent of p21ras

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Isolation of DNA sequences amplified at chromosome 19q13.1-q13.2 including the AKT2 locus in human pancreatic cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The IRS-1 signaling system

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Stress-activated protein kinases: activation, regulation and function.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein modules and signalling networks

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulating cell proliferation: as easy as APC.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

p70 S6 kinase: an enigma with variations

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: involvement of MEK upstream of Bad phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

The pleckstrin homology domain: an intriguing multifunctional protein module

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin 3-dependent survival by the Akt protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Thymic lymphoma induction by the AKT8 murine retrovirus

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Sphingomyelin breakdown and cell fate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

TOR signalling and control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

G-Protein-coupled receptors and Fcgamma-receptors mediate activation of Akt/protein kinase B in human phagocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Signalling through the lipid products of phosphoinositide-3-OH kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential regulation of the HepG2 and adipocyte/muscle glucose transporters in 3T3L1 adipocytes. Effect of chronic glucose deprivation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction by receptors with tyrosine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphoinositide 3-kinases: a conserved family of signal transducers

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Upstream stimulatory factor binding to the E-box at -65 is required for insulin regulation of the fatty acid synthase promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulin stimulation of the fatty acid synthase promoter is mediated by the phosphatidylinositol 3-kinase pathway. Involvement of protein kinase B/Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction by lymphocyte antigen receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Intracellular signalling: putting JAKs on the kinase MAP.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Integrin-linked protein kinase regulates fibronectin matrix assembly, E-cadherin expression, and tumorigenicity

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Solution structure of a pleckstrin-homology domain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2898%2900071-0

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0163-7258(98)00071-0

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

ResearchGate publication ID

0 references

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