(Q33774967)

29 July 2017

1 reference

title

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity (English)

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29 July 2017

Ali IU

1

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29 July 2017

Schriml LM

series ordinal

2

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29 July 2017

Dean M

series ordinal

3

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29 July 2017

language of work or name

English

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publication date

1 November 1999

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Journal of the National Cancer Institute

29 July 2017

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29 July 2017

91

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29 July 2017

1922-1932

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29 July 2017

22

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

29 July 2017

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Cowden syndrome and Lhermitte-Duclos disease in a family: a single genetic syndrome with pleiotropy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Inherited mutations in PTEN that are associated with breast cancer, cowden disease, and juvenile polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Germline mutations in PTEN are present in Bannayan-Zonana syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

The genetic basis of Cowden's syndrome: three novel mutations in PTEN/MMAC1/TEP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Identification of a novel PTEN mutation (L139X) in a patient with Cowden disease and Sjögren's syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Lhermitte-Duclos disease as a component of Cowden's syndrome. Case report and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

PTEN and inherited hamartoma-cancer syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Variant manifestation of Cowden disease in Japan: hamartomatous polyposis of the digestive tract with mutation of the PTEN gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

A gene for familial juvenile polyposis maps to chromosome 18q21.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Microsatellite instability in sporadic endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

PTEN1 is frequently mutated in primary endometrial carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Frameshift mutation: determinants of specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

A tiger behind many doors: multiple genetic pathways to malignant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

PTEN mutations in gliomas and glioneuronal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

p53 and PTEN gene mutations in gemistocytic astrocytomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Mutation in the PTEN/MMAC1 gene in archival low grade and high grade gliomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

PTEN/MMAC1/TEP1 involvement in primary prostate cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

p53 and APC gene mutations: software and databases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

The coordinated action of protein tyrosine phosphatases and kinases in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Phosphatases and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

21 January 2018

Identifiers

DOI

10.1093/JNCI/91.22.1922

1 reference

29 July 2017

1 reference