(Q33797150)

29 July 2017

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title

Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts (English)

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29 July 2017

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S Gerondakis

1

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29 July 2017

M Grossmann

2

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29 July 2017

Y Nakamura

3

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29 July 2017

T Pohl

4

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29 July 2017

R Grumont

5

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29 July 2017

language of work or name

English

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publication date

1 November 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

6888-6895

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29 July 2017

49

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203236

29 July 2017

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cites work

Genetic approaches to study Rel/NF-kappa B/I kappa B function in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Expression of constitutively active IkappaB beta in T cells of transgenic mice: persistent NF-kappaB activity is required for T-cell immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Control of apoptosis by Rel/NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Expression of relB is required for the development of thymic medulla and dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Inhibition of NF-kappaB activity results in disruption of the apical ectodermal ridge and aberrant limb morphogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Requirement for NF-kappaB in osteoclast and B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

The regulation and roles of Rel/NF-kappa B transcription factors during lymphocyte activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Control of development and immunity by rel transcription factors in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Role of Rel/NF-kappaB transcription factors during the outgrowth of the vertebrate limb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Multiple signals converging on NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein I kappa B alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Aberrant rel/nfkb genes and activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Immunological defects in mice with a targeted disruption in Bcl-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Limb and skin abnormalities in mice lacking IKKalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

p50-NF-kappaB complexes partially compensate for the absence of RelB: severely increased pathology in p50(-/-)relB(-/-) double-knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

IEX-1L, an apoptosis inhibitor involved in NF-kappaB-mediated cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

7 January 2021

Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

7 January 2021

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

7 January 2021

RelB is essential for the development of myeloid-related CD8alpha- dendritic cells but not of lymphoid-related CD8alpha+ dendritic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203236

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203236

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Dimensions Publication ID

29 July 2017

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1 reference