(Q33797168)

29 July 2017

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title

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel (English)

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29 July 2017

Gilmore TD

1

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29 July 2017

language of work or name

English

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publication date

1 November 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

6925-6937

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29 July 2017

49

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203222

29 July 2017

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cites work

The v-rel oncogene encodes a kappa B enhancer binding protein that inhibits NF-kappa B function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Control of apoptosis by Rel/NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

A nonimmunosuppressive helper virus allows high efficiency induction of B cell lymphomas by reticuloendotheliosis virus strain T.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Expression of v-rel induces mature B-cell lines that reflect the diversity of avian immunoglobulin heavy- and light-chain rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

c-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1/S-phase transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Expression of immunoglobulin genes in the avian embryo bone marrow revealed by retroviral transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Stochastic rearrangement of immunoglobulin variable-region genes in chicken B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Hematopoietic cells transformed in vitro by REVT avian reticuloendotheliosis virus express characteristics of very immature lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

A conditional mutant of vRel containing sequences from the human estrogen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Rearranged NFKB-2 genes in lymphoid neoplasms code for constitutively active nuclear transactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Mapping of a serine-rich domain essential for the transcriptional, antiapoptotic, and transforming activities of the v-Rel oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Degradation of proto-oncoprotein c-Rel by the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Substitution of 5′ helper virus sequences into non-rel portion of reticuloendotheliosis virus strain T suppresses transformation of chicken spleen cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Rearrangements of chicken immunoglobulin genes in lymphoid cells transformed by the avian retroviral oncogene v-rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Rel-associated pp40: an inhibitor of the rel family of transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Differential pp40I kappa B-beta inhibition of DNA binding by rel proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Transformation of chick embryo fibroblasts by reticuloendotheliosis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Isolation and characterization of reticuloendotheliosis virus transformed bone marrow cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Secretion of a virus-regulated factor by clonal variants of reticuloendotheliosis virus-transformed hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Identification of the v-rel protein in REV-T transformed chicken bone marrow cells and expression in Cos1 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

The N-terminal env-derived amino acids of v-rel are required for full transforming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Malignant transformation by mutant Rel proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Different localization of the product of the v-rel oncogene in chicken fibroblasts and spleen cells correlates with transformation by REV-T.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Transactivation of gene expression by nuclear and cytoplasmic rel proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Expression of the oncogene of avian reticuloendotheliosis virus in Escherichia coli and identification of the transforming protein in reticuloendotheliosis virus T-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Transformation by reticuloendotheliosis virus: Development of a focus assay and isolation of a nontransforming virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Hematopoietic cell transformation by reticuloendotheliosis virus: Characterization of the genetic defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Amino-terminal amino acid sequence of the major structural polypeptides of avian retroviruses: sequence homology between reticuloendotheliosis virus p30 and p30s of mammalian retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

c-rel activates but v-rel suppresses transcription from kappa B sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Characterization of a novel promoter insertion in the c-rel locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Interaction of the v-rel protein with an NF-kappa B DNA binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Oncogenic transformation by vrel requires an amino-terminal activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

AP-1 factors play an important role in transformation induced by the v-rel oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Avian lymphomatosis. IX. Mortality and serological response of chickens of various ages to graded doses of T strain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Role of Nr13 in regulation of programmed cell death in the bursa of Fabricius

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Avian reticuloendotheliosis virus: Identification of the hematopoietic target cell for transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Retroviral transformation in vitro of chicken T cells expressing either alpha/beta or gamma/delta T cell receptors by reticuloendotheliosis virus strain T.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Transformation of avian lymphoid cells by reticuloendotheliosis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Expression of the v-rel oncogene in reticuloendotheliosis virus-transformed fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

A protein kinase-A recognition sequence is structurally linked to transformation by p59v-rel and cytoplasmic retention of p68c-rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Induction of apoptosis during normal and neoplastic B-cell development in the bursa of Fabricius

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Activators and target genes of Rel/NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Isolation of a cDNA encoding a novel chicken chemokine homologous to mammalian macrophage inflammatory protein-1 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Characterization of changes in gene expression associated with malignant transformation by the NF-kappaB family member, v-Rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Aberrant rel/nfkb genes and activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Detection and characterization of the protein encoded by the v-rel oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Loss of IkappaB alpha-mediated control over nuclear import and DNA binding enables oncogenic activation of c-Rel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

A threshold nuclear level of the v-Rel oncoprotein is required for transformation of avian lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Characterisation of cell lines transformed in vivo and in vitro by reticuloendotheliosis virus-T strain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

A recombinant murine retrovirus expressing v-rel is cytopathic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Nucleotide sequence of v-rel: the oncogene of reticuloendotheliosis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Activation of oncogenicity of the c-rel proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

The v-rel oncogene product is complexed to a 40-kDa phosphoprotein in transformed lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

The transforming protein of avian reticuloendotheliosis virus is a soluble cytoplasmic protein which is associated with a protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Interaction of the v-Rel oncoprotein with NF-kappaB and IkappaB proteins: heterodimers of a transformation-defective v-Rel mutant and NF-2 are functional in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Lymphomas resembling lymphoid leukosis in chickens inoculated with reticuloendotheliosis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Avian reticuloendotheliosis virus contains a new class of oncogene of Turkey origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Functional interaction of the v-Rel and c-Rel oncoproteins with the TATA-binding protein and association with transcription factor IIB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

The v-Rel oncoprotein complexes with new Rel- and RelA-related proteins in transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

ch-IAP1, a member of the inhibitor-of-apoptosis protein family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

v-rel Induces ectopic expression of an adhesion molecule, DM-GRASP, during B-lymphoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Rearrangement and diversification of immunoglobulin light-chain genes in lymphoid cells transformed by reticuloendotheliosis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

The v-rel oncogene of avian reticuloendotheliosis virus transforms immature and mature lymphoid cells of the B cell lineage in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

Rel blocks both anti-Fas- and TNF alpha-induced apoptosis and an intact Rel transactivation domain is essential for this effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

A chicken c-Rel-estrogen receptor chimeric protein shows conditional nuclear localization, DNA binding, transformation and transcriptional activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Avian reticuloendotheliosis viruses: evolutionary linkage with mammalian type C retroviruses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

The Rel family: models for transcriptional regulation and oncogenic transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Reticuloendotheliosis virus: detection of immunological relationship to mammalian type C retroviruses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Structure and expression of c-rel, the cellular homolog to the oncogene of reticuloendotheliosis virus strain T

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Avian reticuloendotheliosis virus-transformed lymphoid cells contain multiple pp59v-rel complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Heterologous C-terminal sequences disrupt transcriptional activation and oncogenesis by p59v-rel.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

v-rel oncoproteins in the nucleus and in the cytoplasm transform chicken spleen cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Avian reticuloendotheliosis virus: characterization of genome structure by heteroduplex mapping

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Isolation and development of a reticuloendotheliosis virus-transformed lymphoblastoid cell line from chicken spleen cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Separation of reticuloendotheliosis virus from avian tumor viruses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Insertion of several different DNAs in reticuloendotheliosis virus strain T suppresses transformation by reducing the amount of subgenomic mRNA.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Differences in kappaB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Specific integration of REV proviruses in avian bursal lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Caspases: the proteases of the apoptotic pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Avian reticuloendotheliosis virus (strain T). IV. Infectivity and transmissibility in day-old cockerels.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Genome of Reticuloendotheliosis Virus: Characterization by Use of Cloned Proviral DNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

vRel is an inactive member of the Rel family of transcriptional activating proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Avian I kappa B alpha is transcriptionally induced by c-Rel and v-Rel with different kinetics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

NF-kappa B p100 is one of the high-molecular-weight proteins complexed with the v-Rel oncoprotein in transformed chicken spleen cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Localization of the v-rel protein in reticuloendotheliosis virus strain T-transformed lymphoid cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Alterations within pp59v-rel-containing protein complexes following the stimulation of REV-T-transformed lymphoid cells with zinc

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Spectrum of infectivity and transmission of the T-virus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Serine phosphorylation of the v-rel oncogene product/pp40 complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

The v-rel oncogene: insights into the mechanism of transcriptional activation, repression, and transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Tolerance, viral shedding, and neoplasia in chickens infected with non-defective reticuloendotheliosis viruses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

A mutant Rel-homology domain promotes transcription by p50/NFkappaB1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

v-Rel prevents apoptosis in transformed lymphoid cells and blocks TNFalpha-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203222

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203222

1 reference

Dimensions Publication ID

29 July 2017

1035605625

0 references

Fatcat ID

release_nsweiqprt5g2tdw4xm5q5azidu

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nsweiqprt5g2tdw4xm5q5azidu

24 November 2022

mapped directly with Wikidata item

1 reference