(Q33801327)

English

The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy

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scholarly article

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy (English)

1 reference

Europe PubMed Central

29 July 2017

Hepatitis C virus

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Bartenschlager R

1

1 reference

Europe PubMed Central

29 July 2017

publication date

1 May 1999

1 reference

Europe PubMed Central

29 July 2017

Journal of Viral Hepatitis

1 reference

Europe PubMed Central

29 July 2017

6

1 reference

Europe PubMed Central

29 July 2017

165-181

1 reference

Europe PubMed Central

29 July 2017

3

1 reference

Europe PubMed Central

29 July 2017

Chronic hepatitis C: the virus, its discovery and the natural history of the disease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Epidemiology of hepatitis C

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Therapy of hepatitis C: overview

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Virus-encoded proteinases of the Flaviviridae

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Secondary structure of the 5' nontranslated regions of hepatitis C virus and pestivirus genomic RNAs

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

A novel sequence found at the 3' terminus of hepatitis C virus genome

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Analysis of hepatitis C virus capsid, E1, and E2/NS1 proteins expressed in insect cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Homotypic interaction and multimerization of hepatitis C virus core protein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Analysis of hepatitis C virus core protein interaction domains

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Suppression of apoptotic cell death by hepatitis C virus core protein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Transcriptional repression of p53 promoter by hepatitis C virus core protein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Expression and characterization of glycoprotein gp35 of hepatitis C virus using recombinant vaccinia virus

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Complex processing and protein:protein interactions in the E2:NS2 region of HCV.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

A second hepatitis C virus-encoded proteinase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Two proteinase activities in HCV polypeptide expressed in insect cells using baculovirus vector.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

In vitro cleavage of hepatitis C virus polyprotein substrates by purified recombinant NS3 protease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Expression, purification, and partial characterization of HCV RNA polymerase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Expression of recombinant hepatitis C virus non-structural protein 5B in Escherichia coli

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Hepatitis C virus core protein: carboxy-terminal boundaries of two processed species suggest cleavage by a signal peptide peptidase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Hepatitis C virus NS2-3 proteinase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Families of metalloendopeptidases and their relationships

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Mechanism of autoproteolysis at the NS2-NS3 junction of the hepatitis C virus polyprotein

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Purification and characterization of the NS3 serine protease domain of hepatitis C virus expressed in Saccharomyces cerevisiae.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

In vitro activity of hepatitis C virus protease NS3 purified from recombinant Baculovirus-infected Sf9 cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Enhancement of hepatitis C virus NS3 proteinase activity by association with NS4A-specific synthetic peptides: identification of sequence and critical residues of NS4A for the cofactor activity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

A zinc binding site in viral serine proteinases

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Substrate specificity of the NS3 serine proteinase of hepatitis C virus as determined by mutagenesis at the NS3/NS4A junction

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Substrate specificity of the hepatitis C virus serine protease NS3.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Redesigning the substrate specificity of the hepatitis C virus NS3 protease.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Determinants of substrate specificity in the NS3 serine proteinase of the hepatitis C virus.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Differential roles of the 5' untranslated regions of cucumber mosaic virus RNAs 1, 2, 3 and 4 in translational competition

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Poly(U) binding activity of hepatitis C virus NS3 protein, a putative RNA helicase

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

An in vitro assay for hepatitis C virus NS3 serine proteinase.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

The hepatitis C virus NS3 serine proteinase and NS4A cofactor: establishment of a cell-free trans-processing assay

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

In vivo and in vitro trans-cleavage activity of hepatitis C virus serine proteinase expressed by recombinant baculoviruses

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Recombinant baculovirus-expressed NS3 proteinase of hepatitis C virus shows activity in cell-based and in vitro assays

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Synthetic depsipeptide substrates for the assay of human hepatitis C virus protease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Expression of a hepatitis C virus NS3 protease-NS4A fusion protein in Escherichia coli

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Bacterial expression and analysis of cleavage activity of HCV serine proteinase using recombinant and synthetic substrate.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Establishment of an in vitro assay system for screening hepatitis C virus protease inhibitors using high performance liquid chromatography

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

A continuous assay of hepatitis C virus protease based on resonance energy transfer depsipeptide substrates

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Enzymatic characterization of purified NS3 serine proteinase of hepatitis C virus expressed in Escherichia coli

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Product inhibition of the hepatitis C virus NS3 protease

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Potent peptide inhibitors of human hepatitis C virus NS3 protease are obtained by optimizing the cleavage products

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Isolation of RNA aptamers specific to the NS3 protein of hepatitis C virus from a pool of completely random RNA.

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Novel hepatitis C virus protease inhibitors: thiazolidine derivatives

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

A novel method for analysis of viral proteinase activity encoded by hepatitis C virus in cultured cells

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Generation of a novel poliovirus with a requirement of hepatitis C virus protease NS3 activity

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Identification of two flavivirus-like genomes in the GB hepatitis agent

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Viral cysteine proteinases

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Management of hepatitis C

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00152.X

21 January 2018

Identifiers

10.1046/J.1365-2893.1999.00152.X

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

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