(Q33801346)

29 July 2017

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title

The non-structural 5A protein of hepatitis C virus (English)

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29 July 2017

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Pawlotsky JM

1

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29 July 2017

Germanidis G

series ordinal

2

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29 July 2017

language of work or name

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1 September 1999

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Journal of Viral Hepatitis

29 July 2017

published in

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29 July 2017

volume

6

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29 July 2017

issue

5

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29 July 2017

page(s)

343-356

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Complete 5' noncoding region is necessary for the efficient internal initiation of hepatitis C virus RNA.

29 July 2017

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Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA

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Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus

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The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor

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Production of nonstructural proteins of hepatitis C virus requires a putative viral protease encoded by NS3.

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A central hydrophobic domain of the hepatitis C virus NS4A protein is necessary and sufficient for the activation of the NS3 protease

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Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins

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Pretreatment virus load and multiple amino acid substitutions in the interferon sensitivity-determining region predict the outcome of interferon treatment in patients with chronic genotype 1b hepatitis C virus infection

21 January 2018

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Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit

21 January 2018

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The hepatitis C virus NS2 protein generated by NS2-3 autocleavage is required for NS5A phosphorylation

21 January 2018

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Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins

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Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication

21 January 2018

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21 January 2018

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21 January 2018

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The amino terminal deletion mutants of hepatitis C virus nonstructural protein NS5A function as transcriptional activators in yeast

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21 January 2018

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21 January 2018

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Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase

21 January 2018

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21 January 2018

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Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain I can act as transdominant inhibitors and induce malignant transformation

21 January 2018

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Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein

21 January 2018

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A template for the protein kinase family

21 January 2018

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Protein kinases — structure and function

21 January 2018

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Regulation of the interferon-induced PKR: can viruses cope?

21 January 2018

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Therapy of hepatitis C: overview

21 January 2018

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Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (I

21 January 2018

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Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group

21 January 2018

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Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. International Hepatitis Interventional Therapy Group

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection

21 January 2018

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https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-beta therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

The prognostic relevance of the nonstructural 5A gene interferon sensitivity determining region is different in infections with genotype 1b and 3a isolates of hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

Mutations of hepatitis C virus 1b NS5A 2209-2248 amino acid sequence do not predict the response to recombinant interferon-alfa therapy in French patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

Variation in the hepatitis C virus NS5a region in relation to hypervariable region 1 heterogeneity during interferon treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

Mutations in NS5A region of hepatitis C virus genome correlate with presence of NS5A antibodies and response to interferon therapy for most common European hepatitis C virus genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

Pattern of HCV antibodies with special reference to NS5A reactivity in HCV-infected patients: relation to viral genotype, cryoglobulinemia and response to interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

The interferon sensitivity determining region: all hepatitis C virus isolates are not the same

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

The complete coding sequence of hepatitis C virus genotype 5a, the predominant genotype in South Africa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2893.1999.00185.X

10.1046/J.1365-2893.1999.00185.X

21 January 2018

Identifiers

DOI

1 reference

29 July 2017

1 reference