(Q33843055)

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An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells

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Europe PubMed Central

PubMed publication ID

29 July 2017

An RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

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author name string

Meilen C Muñoz

1

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Europe PubMed Central

PubMed publication ID

29 July 2017

Diana A Yanez

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

Jeremy M Stark

3

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Europe PubMed Central

PubMed publication ID

29 July 2017

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publication date

14 May 2014

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Europe PubMed Central

PubMed publication ID

29 July 2017

number of pages

14

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Nucleic Acids Research

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Europe PubMed Central

PubMed publication ID

29 July 2017

42

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Europe PubMed Central

PubMed publication ID

29 July 2017

12

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Europe PubMed Central

PubMed publication ID

29 July 2017

7720-7733

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Europe PubMed Central

PubMed publication ID

29 July 2017

copyright license

Creative Commons Attribution 3.0 Unported

4 October 2016

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April 2022 Public Data File from Crossref

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Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

1 reference

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28 July 2018

The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A.

1 reference

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Genome engineering using the CRISPR-Cas9 system

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28 July 2018

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

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RNA-guided human genome engineering via Cas9

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Multiplex genome engineering using CRISPR/Cas systems

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28 July 2018

RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1

1 reference

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28 July 2018

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

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Coupling endonucleases with DNA end-processing enzymes to drive gene disruption

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TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes

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28 July 2018

RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1.

1 reference

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Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks

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28 July 2018

A novel ubiquitin mark at the N-terminal tail of histone H2As targeted by RNF168 ubiquitin ligase

1 reference

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28 July 2018

A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network

1 reference

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28 July 2018

Correct end use during end joining of multiple chromosomal double strand breaks is influenced by repair protein RAD50, DNA-dependent protein kinase DNA-PKcs, and transcription context

1 reference

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28 July 2018

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

1 reference

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Integrated genomic analyses of ovarian carcinoma

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Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome

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Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

1 reference

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UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway

1 reference

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28 July 2018

Targeting homologous recombination repair defects in cancer

1 reference

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ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

1 reference

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

1 reference

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Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

1 reference

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28 July 2018

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

1 reference

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28 July 2018

The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination

1 reference

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A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

1 reference

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Limiting the persistence of a chromosome break diminishes its mutagenic potential

1 reference

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28 July 2018

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

1 reference

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Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

1 reference

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Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair

1 reference

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28 July 2018

Activation of the cellular DNA damage response in the absence of DNA lesions

1 reference

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28 July 2018

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

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RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

Control of sister chromatid recombination by histone H2AX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

Genetic steps of mammalian homologous repair with distinct mutagenic consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

53BP1 is required for class switch recombination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4081061

28 July 2018

RNF168, a new RING finger, MIU-containing protein that modifies chromatin by ubiquitination of histones H2A and H2AX

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU421

21 January 2018

Push back to respond better: regulatory inhibition of the DNA double-strand break response

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU421

21 January 2018

Loss of 53BP1 is a gain for BRCA1 mutant cells.

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU421

21 January 2018

I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU421

21 January 2018

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU421

21 January 2018

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU421

21 January 2018

Critical roles of ring finger protein RNF8 in replication stress responses

1 reference

https://api.crossref.org/works/10.1093%2FNAR%2FGKU421

21 January 2018

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

1 reference

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21 January 2018

Identifiers

10.1093/NAR/GKU421

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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