(Q33847590)

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Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation

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Europe PubMed Central

PubMed publication ID

29 July 2017

Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation (English)

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Europe PubMed Central

PubMed publication ID

29 July 2017

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24619359%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Stefan G. Roberts

8

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9 June 2020

Brigitte Royer-Pokora

10

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Brigitte Royer-Pokora

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9 June 2020

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Heinrich Schwindt

2

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9 June 2020

Artur Brandt

3

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9 June 2020

Manfred Beier

4

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9 June 2020

Nicole Görldt

5

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9 June 2020

Paul Romaniuk

6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24619359%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Eneda Toska

7

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24619359%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Hans-Dieter Royer

9

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9 June 2020

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11 March 2014

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29 July 2017

Human Molecular Genetics

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9 June 2020

23

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Europe PubMed Central

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9 June 2020

15

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24619359%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

3958-3974

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24619359%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

describes a project that uses

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Europe PubMed Central

22 June 2022

https://europepmc.org/article/PMC/4082364

based on heuristic

inferred from PubMed Central ID database lookup

p53 Dimers associate with a head-to-tail response element to repress cyclin B transcription

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

WT1 and its transcriptional cofactor BASP1 redirect the differentiation pathway of an established blood cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

p53-dependent repression of polo-like kinase-1 (PLK1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Correct mRNA processing at a mutant TT splice donor in FANCC ameliorates the clinical phenotype in patients and is enhanced by delivery of suppressor U1 snRNAs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Wilms tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells and express molecular markers of paraxial mesoderm

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Transcriptional control of the proliferation cluster by the tumor suppressor p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

A versatile viral system for expression and depletion of proteins in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Contribution of individual amino acids to the RNA binding activity of the Wilms' tumor suppressor protein WT1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Oncogene addiction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Wt1 negatively regulates beta-catenin signaling during testis development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

The post-transcriptional roles of WT1, a multifunctional zinc-finger protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

A tumor suppressor and oncogene: the WT1 story.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

The modulation of WTI transcription function by cofactors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Common markers of proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Transcriptional regulation by WT1 in development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

The p53 response: emerging levels of co-factor complexity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

The Wilms tumor suppressor-1 target gene podocalyxin is transcriptionally repressed by p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

WT1 regulates the expression of the major glomerular podocyte membrane protein Podocalyxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Presence of WT1, the Wilm's tumor suppressor gene product, in nuclear poly(A)(+) ribonucleoprotein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Overlapping RNA and DNA binding domains of the wt1 tumor suppressor gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

RNA binding by the Wilms tumor suppressor zinc finger proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Truncated WT1 mutants alter the subnuclear localization of the wild-type protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Wilms' tumour gene and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

High affinity binding sites for the Wilms' tumour suppressor protein WT1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Binding of the Wilms' tumor locus zinc finger protein to the EGR-1 consensus sequence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

Transcriptional repression mediated by the WT1 Wilms tumor gene product

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

5 July 2018

An RNA recognition motif in Wilms' tumour protein (WT1) revealed by structural modelling.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU111

21 January 2018

Analysis of native WT1 protein from frozen human kidney and Wilms' tumors

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU111

21 January 2018

Nuclear transport of Wilms' tumour protein Wt1 involves importins α and β.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU111

21 January 2018

Characterization of RNA aptamer binding by the Wilms' tumor suppressor protein WT1.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU111

21 January 2018

Leukemia associated mutant Wilms' tumor gene 1 protein promotes expansion of human hematopoietic progenitor cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU111

21 January 2018

CDC20, a potential cancer therapeutic target, is negatively regulated by p53.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU111

21 January 2018

Two molecular subgroups of Wilms' tumors with or without WT1 mutations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4082364

29 October 2018

WT1--more than a transcription factor?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24619359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript

1 reference

https://pubmed.ncbi.nlm.nih.gov/24619359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of individual base pairs to the interaction of TFIIIA with the Xenopus 5S RNA gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/24619359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forced expression of the Wilms tumor 1 (WT1) gene inhibits proliferation of human hematopoietic CD34(+) progenitor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24619359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1093/HMG/DDU111

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24619359%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24619359%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24619359%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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