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Cell-cycle inhibitors: three families united by a common cause
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
review article
1 reference
stated in
Europe PubMed Central
title
Cell-cycle inhibitors: three families united by a common cause
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
author
Anxo Vidal
1 reference
stated in
ORCID Public Data File 2021
author name string
Vidal A
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
Koff A
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
language of work or name
English
0 references
publication date
1 April 2000
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
published in
Gene
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
volume
247
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
page(s)
1-15
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
issue
1-2
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
cites work
Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.
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Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.
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Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter.
1 reference
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Crossref
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7 January 2021
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inferred from DOI database lookup
Retinoblastoma protein recruits histone deacetylase to repress transcription
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Radiation-induced cell cycle arrest compromised by p21 deficiency
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
p21 is a critical CDK2 regulator essential for proliferation control in Rb-deficient cells
1 reference
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Crossref
reference URL
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7 January 2021
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inferred from DOI database lookup
TGF-beta1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth.
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Crossref
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7 January 2021
based on heuristic
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Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Dual cyclin-binding domains are required for p107 to function as a kinase inhibitor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement for a functional Rb-1 gene in murine development
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
New insights into the tumor suppression function of P27(kip1)
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Shared role of the pRB-related p130 and p107 proteins in limb development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Association of human cyclin E with a periodic G1-S phase protein kinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The regulation of E2F by pRB-family proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
WAF1, a potential mediator of p53 tumor suppression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TGF beta inhibition of Cdk4 synthesis is linked to cell cycle arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the cell cycle by the Rb tumor suppressor family.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The murine gene p27Kip1 is haplo-insufficient for tumour suppression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transcriptional Regulation of the p21(WAF1/CIP1)Gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rescue of Cyclin D1 Deficiency by Knockin Cyclin E
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genomic imprinting of human p57KIP2 and its reduced expression in Wilms' tumors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Translational control of p27Kip1 accumulation during the cell cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of an Rb mutation in the mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis of the p16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Strain-dependent myeloid hyperplasia, growth deficiency, and accelerated cell cycle in mice lacking the Rb-related p107 gene.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of p107: functional overlap between p107 and Rb
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Genes in the RB pathway and their knockout in mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Specific enzymatic dephosphorylation of the retinoblastoma protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin E-induced S phase without activation of the pRb/E2F pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rb interacts with histone deacetylase to repress transcription
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rapamycin resistance tied to defective regulation of p27Kip1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Retinoblastoma protein represses transcription by recruiting a histone deacetylase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Induced expression of p16(INK4a) inhibits both CDK4- and CDK2-associated kinase activity by reassortment of cyclin-CDK-inhibitor complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
D-type cyclin-dependent kinase activity in mammalian cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Growth suppression by p16ink4 requires functional retinoblastoma protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin-dependent kinases: engines, clocks, and microprocessors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The retinoblastoma gene family: cousins with overlapping interests.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p130 is dispensable in peripheral T lymphocytes: evidence for functional compensation by p107 and pRB.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Early loss of the retinoblastoma gene is associated with impaired growth inhibitory innervation during melanotroph carcinogenesis in Rb+/- mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the cyclin E gene by transcription factor E2F1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin-dependent regulation of G1 in mammalian fibroblasts.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
G1 events and regulation of cell proliferation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p27 and Rb are on overlapping pathways suppressing tumorigenesis in mice.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin D-CDK subunit arrangement is dependent on the availability of competing INK4 and p21 class inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p107 is a suppressor of retinoblastoma development in pRb-deficient mice
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The INK4 family of cell cycle inhibitors in cancer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of the INK4a locus in tumor suppression and cell mortality.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin E-CDK2 is a regulator of p27Kip1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mammalian G1 cyclins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cancer cell cycles
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Tumor surveillance via the ARF-p53 pathway.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CDK inhibitors: positive and negative regulators of G1-phase progression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin D1 provides a link between development and oncogenesis in the retina and breast.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cell cycle control of DNA replication.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HuR regulates p21 mRNA stabilization by UV light
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of active transcriptional repression by the retinoblastoma protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p130 and p107 use a conserved domain to inhibit cellular cyclin-dependent kinase activity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p21 is a universal inhibitor of cyclin kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p21(CIP1) and p57(KIP2) control muscle differentiation at the myogenin step
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
INK4d-deficient mice are fertile despite testicular atrophy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0378-1119%2800%2900092-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0378-1119(00)00092-5
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
PubMed ID
10773440
1 reference
stated in
Europe PubMed Central
PubMed ID
10773440
retrieved
29 July 2017
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