(Q33897308)

English

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24726384%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells (English)

1 reference

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14 March 2020

1 reference

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tumor progression

1 reference

based on heuristic

inferred from title

4

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14 March 2020

9

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14 March 2020

Pier Paolo Pandolfi

18

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14 March 2020

Sabina Signoretti

7

object named as

Sabina Signoretti

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14 March 2020

5

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Kerri Burgess

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14 March 2020

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author name string

Han Xie

1

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14 March 2020

Jun-Ichi Hanai

2

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14 March 2020

Jian-Guo Ren

3

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14 March 2020

Parul Bhargava

6

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14 March 2020

Julia Billiard

8

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14 March 2020

Aaron Grant

10

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14 March 2020

Xiaoen Wang

11

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14 March 2020

Pawel K Lorkiewicz

12

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14 March 2020

Sabrina Schatzman

13

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14 March 2020

Michael Bousamra

14

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14 March 2020

Andrew N Lane

15

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14 March 2020

Richard M Higashi

16

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14 March 2020

Teresa W M Fan

17

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14 March 2020

Vikas P Sukhatme

19

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14 March 2020

Pankaj Seth

20

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14 March 2020

publication date

10 April 2014

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14 March 2020

Cell Metabolism

1 reference

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14 March 2020

19

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14 March 2020

795-809

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14 March 2020

5

1 reference

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14 March 2020

Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

ATP citrate lyase knockdown impacts cancer stem cells in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

1 reference

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28 July 2018

Metabolic differentiation in the embryonic retina

1 reference

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28 July 2018

Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Stable isotope-resolved metabolomics and applications for drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Stable isotope resolved metabolomics of lung cancer in a SCID mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Cancer stem cells, hypoxia and metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Cancer cell metabolism: Warburg and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

The epithelial-mesenchymal transition generates cells with properties of stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Isotopomer-based metabolomic analysis by NMR and mass spectrometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Development of new mouse lung tumor models expressing EGFR T790M mutants associated with clinical resistance to kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Maximizing mouse cancer models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

ATP citrate lyase inhibition can suppress tumor cell growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

On the Origin of Cancer Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Prospective identification of tumorigenic breast cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Correlation of high lactate levels in head and neck tumors with incidence of metastasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

28 July 2018

LDH-A silencing suppresses breast cancer tumorigenicity through induction of oxidative stress mediated mitochondrial pathway apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

29 October 2018

KRAS mutations in non-small cell lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

29 October 2018

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer

1 reference

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29 October 2018

Cancer stem cells in solid tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

29 October 2018

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

29 October 2018

Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4096909

29 October 2018

Why do cancers have high aerobic glycolysis?

1 reference

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29 October 2018

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

1 reference

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29 October 2018

The tumour microenvironment: causes and consequences of hypoxia and acidity. Introduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/24726384

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo 13 carbon metabolic imaging at 3T with hyperpolarized 13C-1-pyruvate

1 reference

https://pubmed.ncbi.nlm.nih.gov/24726384

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular detection of early lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24726384

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory effect of tumor cell-derived lactic acid on human T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24726384

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.CMET.2014.03.003

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Europe PubMed Central

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14 March 2020

1 reference

Europe PubMed Central

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14 March 2020

1 reference

Europe PubMed Central

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14 March 2020

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