(Q33901287)

29 July 2017

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title

Metabolism and pharmacokinetics of oxazaphosphorines (English)

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29 July 2017

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Boddy AV

1

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PubMed ID

10803453

29 July 2017

Yule SM

series ordinal

2

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29 July 2017

1 April 2000

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Clinical Pharmacokinetics

29 July 2017

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29 July 2017

38

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29 July 2017

291-304

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29 July 2017

4

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https://scigraph.springernature.com/pub.10.2165/00003088-200038040-00001

29 July 2017

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cites work

Metabolism of ifosfamide during a 3 day infusion

1 reference

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Pharmacokinetics of ifosfamide and its enantiomers following a single 1 h intravenous infusion of the racemate in patients with small cell lung carcinoma

21 January 2018

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Effect of body weight on the pharmacokinetics of cyclophosphamide in breast cancer patients.

21 January 2018

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12 December 2020

Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance

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12 December 2020

Identification of aldophosphamide as a metabolite of cyclophosphamide in vitro and in vivo in humans

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12 December 2020

An overview of cyclophosphamide and ifosfamide pharmacology

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12 December 2020

Cytochrome P450 expression is a common molecular event in soft tissue sarcomas

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12 December 2020

Metabolic jeopardy with high-dose cyclophosphamide?--not so fast

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12 December 2020

Glutathione depletion as a determinant of sensitivity of human leukemia cells to cyclophosphamide

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12 December 2020

Cyclophosphamide and ifosfamide metabolites in the cerebrospinal fluid of children.

1 reference

12 December 2020

Nonlinear pharmacokinetics of cyclophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation

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12 December 2020

Oxime derivatives of the intermediary oncostatic metabolites of cyclophosphamide and ifosfamide: synthesis and deuterium labeling for applications to metabolite quantification

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12 December 2020

Analytical and preparative high-performance liquid chromatographic separation of the enantiomers of ifosfamide, cyclophosphamide and trofosfamide and their determination in plasma

1 reference

12 December 2020

Bone marrow micrometastases in chemotherapy-responsive advanced breast cancer: effect of ex vivo purging with 4-hydroperoxycyclophosphamide

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12 December 2020

Pharmacokinetics of cyclophosphamide and its metabolites in bone marrow transplantation patients

1 reference

12 December 2020

Pharmacokinetics of intravenous cyclophosphamide in man, estimated by gas-liquid chromatography

1 reference

12 December 2020

Pharmacokinetics and bioavailability of oral ifosfamide

1 reference

12 December 2020

Effect of liver failure on the pharmacokinetics of cyclophosphamide

1 reference

12 December 2020

Liquid chromatographic determination of cyclophosphamide enantiomers in plasma by precolumn chiral derivatization

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12 December 2020

Principal xenobiotic-metabolizing enzyme systems in human head and neck squamous cell carcinoma.

1 reference

12 December 2020

Chemotherapy in 998 unselected childhood acute lymphoblastic leukemia patients. Results and conclusions of the multicenter trial ALL-BFM 86.

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12 December 2020

Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response

1 reference

12 December 2020

Urinary stability of carboxycyclophosphamide and carboxyifosfamide, two major metabolites of the anticancer drugs cyclophosphamide and ifosfamide

1 reference

12 December 2020

Sensitivity of aldehyde dehydrogenases in murine tumor and hematopoietic progenitor cells to inhibition by chloral hydrate as determined by the ability of chloral hydrate to potentiate the cytotoxic action of mafosfamide

1 reference

12 December 2020

Pharmacokinetics of ifosfamide administered according to three different schedules in metastatic soft tissue and bone sarcomas

1 reference

12 December 2020

Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles

1 reference

12 December 2020

Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized, crossover trial

1 reference

12 December 2020

Ifosfamide nephrotoxicity: limited influence of metabolism and mode of administration during repeated therapy in paediatrics

1 reference

12 December 2020

Dechloroethylation of ifosfamide and neurotoxicity

1 reference

12 December 2020

Relative contribution of human erythrocyte aldehyde dehydrogenase to the systemic detoxification of the oxazaphosphorines

1 reference

12 December 2020

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

1 reference

12 December 2020

Increased intensification and total dose of cyclophosphamide in a doxorubicin-cyclophosphamide regimen for the treatment of primary breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-22

1 reference

12 December 2020

Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase

1 reference

12 December 2020

Adjuvant cyclophosphamide, methotrexate, and fluorouracil in node-positive breast cancer: the results of 20 years of follow-up

1 reference

12 December 2020

Synergistic interactions between cyclophosphamide or melphalan and VP-16 in a human rhabdomyosarcoma xenograft

1 reference

12 December 2020

Trofosfamide: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the oral treatment of cancer

1 reference

12 December 2020

Ifosfamide stereoselective dichloroethylation and neurotoxicity

1 reference

12 December 2020

Saturable metabolism of continuous high-dose ifosfamide with mesna and GM-CSF: a pharmacokinetic study in advanced sarcoma patients. Swiss Group for Clinical Cancer Research (SAKK).

1 reference

12 December 2020

Individual variation in the activation and inactivation of metabolic pathways of cyclophosphamide

1 reference

12 December 2020

Biologic and therapeutic efficacy of mafosfamide in patients with metastatic renal cell carcinoma

1 reference

12 December 2020

Prolongation of ifosfamide elimination half-life in obese patients due to altered drug distribution

1 reference

12 December 2020

The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion

1 reference

12 December 2020

The comparative pharmacology of cyclophosphamide and ifosfamide

1 reference

12 December 2020

A phase I study of SR-2508 and cyclophosphamide administered by intravenous injection

1 reference

12 December 2020

Sequence-dependent hematological toxicity associated with the 3-hour paclitaxel/cyclophosphamide doublet

1 reference

12 December 2020

Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer

1 reference

12 December 2020

Chemotherapeutic agent permeability to normal brain and delivery to avian sarcoma virus-induced brain tumors in the rodent: observations on problems of drug delivery

1 reference

12 December 2020

Biliary elimination of cyclophosphamide in man

1 reference

12 December 2020

Cyclophosphamide and 4-Hydroxycyclophosphamide/aldophosphamide kinetics in patients receiving high-dose cyclophosphamide chemotherapy

1 reference

12 December 2020

High-dose melphalan and cyclophosphamide with autologous bone marrow rescue for recurrent/progressive malignant brain tumors in children: a pilot pediatric oncology group study.

1 reference

12 December 2020

A mechanism-based pharmacokinetic-enzyme model for cyclophosphamide autoinduction in breast cancer patients

1 reference

12 December 2020

Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans

1 reference

12 December 2020

Short-term versus continuous infusion: no influence on ifosfamide side-chain metabolism

1 reference

12 December 2020

Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis

1 reference

12 December 2020

The role of DNA damage in the resistance of human chronic myeloid leukemia cells to cyclophosphamide analogues

1 reference

12 December 2020

Antitumor activity of optical isomers of cyclophosphamide, ifosfamide and trofosfamide as compared to clinically used racemates

1 reference

12 December 2020

Pharmacokinetics of high-dose cyclophosphamide for bone marrow transplantation

1 reference

12 December 2020

Fractionated administration of high-dose cyclophosphamide: influence on dose-dependent changes in pharmacokinetics and metabolism

1 reference

12 December 2020

Quantitation by gas chromatography-chemical ionization mass spectrometry of cyclophosphamide, phosphoramide mustard, and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapy

1 reference

12 December 2020

Combined thin-layer chromatography-photography-densitometry for the quantification of ifosfamide and its principal metabolites in urine, cerebrospinal fluid and plasma

1 reference

12 December 2020

DNA damage in cyclophosphamide-resistant tumor cells: the role of glutathione.

1 reference

12 December 2020

Metabolism and pharmacokinetics of oral and intravenous ifosfamide

1 reference

12 December 2020

Variability in the pharmacokinetics of cyclophosphamide, methotrexate and 5-fluorouracil in women receiving adjuvant treatment for breast cancer

1 reference

12 December 2020

Intratumoral activation and enhanced chemotherapeutic effect of oxazaphosphorines following cytochrome P-450 gene transfer: development of a combined chemotherapy/cancer gene therapy strategy

1 reference

12 December 2020

The pharmacokinetics and metabolism of ifosfamide during bolus and infusional administration: a randomized cross-over study

1 reference

12 December 2020

Dose escalation of cyclophosphamide in patients with breast cancer: consequences for pharmacokinetics and metabolism

1 reference

12 December 2020

Conditioning regimen-dependent disposition of cyclophosphamide and hydroxycyclophosphamide in human marrow transplantation patients

1 reference

12 December 2020

Repeated high-dose cyclophosphamide administration in bone marrow transplantation: exposure to activated metabolites

1 reference

12 December 2020

Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde

1 reference

12 December 2020

Measurement of DNA cross-linking in patients on ifosfamide therapy using the single cell gel electrophoresis (comet) assay

1 reference

12 December 2020

Nonpredictable pharmacokinetic behavior of high-dose cyclophosphamide in combination with cisplatin and 1,3-bis(2-chloroethyl)-1-nitrosourea

1 reference

12 December 2020

Pharmacokinetics of cyclophosphamide and alkylating activity in man after intravenous and oral administration

1 reference

12 December 2020

Cyclophosphamide metabolism in children with Fanconi's anaemia

1 reference

12 December 2020

Preclinical studies and clinical correlation of the effect of alkylating dose.

1 reference

12 December 2020

Pharmacokinetics of intravenous and oral cyclophosphamide in the presence of methotrexate and fluorouracil

1 reference

12 December 2020

Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture

1 reference

12 December 2020

Investigation of the major human hepatic cytochrome P450 involved in 4-hydroxylation and N-dechloroethylation of trofosfamide

1 reference

12 December 2020

The effect of route of administration and fractionation of dose on the metabolism of ifosfamide

1 reference

12 December 2020

Bioavailability of ifosfamide in patients with bronchial carcinoma

1 reference

12 December 2020

The Biotransformation of Cyclophosphamide in Man: Influence of Prednisone

1 reference

12 December 2020

Pharmacokinetics, metabolism and clinical effect of ifosfamide in breast cancer patients

1 reference

12 December 2020

Therapeutic effects of single-push or fractionated injections or continuous infusion of oxazaphosphorines (cyclophosphamide, ifosfamide, Asta Z 7557)

1 reference

12 December 2020

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

1 reference

12 December 2020

Determination of cyclophosphamide and its metabolites in human plasma by high-performance liquid chromatography-mass spectrometry

1 reference

12 December 2020

Ifosfamide metabolism and pharmacokinetics (review).

1 reference

12 December 2020

Clinical pharmacokinetics of cyclophosphamide

1 reference

12 December 2020

Results of treatment of advanced-stage Burkitt's lymphoma and B cell (SIg+) acute lymphoblastic leukemia with high-dose fractionated cyclophosphamide and coordinated high-dose methotrexate and cytarabine

1 reference

12 December 2020

Stereoselective pharmacokinetics and metabolism of the enantiomers of cyclophosphamide. Preliminary results in humans and rabbits

1 reference

12 December 2020

Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer.

1 reference

12 December 2020

Cyclophosphamide pharmacokinetics in children

1 reference

12 December 2020

Alkylating agents: in vitro studies of cross-resistance patterns in human cell lines.

1 reference

12 December 2020

Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines

1 reference

12 December 2020

The determination of cyclophosphamide and its metabolites in blood plasma as stable trifluoroacetyl derivatives by electron capture chemical ionization gas chromatography/mass spectrometry

1 reference

12 December 2020

Intrathecal 4-hydroperoxycyclophosphamide: neurotoxicity, cerebrospinal fluid pharmacokinetics, and antitumor activity in a rabbit model of VX2 leptomeningeal carcinomatosis

1 reference

12 December 2020

Expression of xenobiotic metabolizing enzymes in breast cancer.

1 reference

12 December 2020

Cyclophosphamide levels in serum and spinal fluid of multiple sclerosis patients treated with immunosuppression

1 reference

12 December 2020

Comparison of continuous infusion and bolus administration of ifosfamide in children

1 reference

12 December 2020

High-performance liquid chromatographic determination of stabilized 4-hydroxyifosfamide in human plasma and erythrocytes

1 reference

12 December 2020

Total body irradiation, thiotepa, and cyclophosphamide as a conditioning regimen for children with acute lymphoblastic leukemia in first or second remission undergoing bone marrow transplantation with HLA-identical siblings

1 reference

12 December 2020

A study of 5 day fractionated ifosfamide pharmacokinetics in consecutive treatment cycles

1 reference

12 December 2020

Phase I trial with pharmacokinetic analyses of high-dose carboplatin, etoposide, and cyclophosphamide with autologous bone marrow transplantation in patients with refractory germ cell tumors

1 reference

12 December 2020

A simple outpatient treatment with oral ifosfamide and oral etoposide for patients with small cell lung cancer (SCLC).

1 reference

12 December 2020

Comparative pharmacokinetics and alkylating activity of fractionated intravenous and oral ifosfamide in patients with bronchogenic carcinoma

1 reference

12 December 2020

The disposition of cyclophosphamide in a group of myeloma patients

1 reference

12 December 2020

The effect of fluconazole on cyclophosphamide metabolism in children

1 reference

12 December 2020

Lack of Ranitidine Effects on Cyclophosphamide Bon Marrow Toxicity or Metabolism: A Placebo-Controlled Clinical Trial

1 reference

12 December 2020

Some studies on the distribution and effects of cyclophosphamide (NSC-26271) in normal and neoplastic tissue

1 reference

12 December 2020

Pharmacokinetics and metabolism of ifosfamide administered as a continuous infusion in children

1 reference

12 December 2020

Cyclophosphamide metabolism in children

1 reference

12 December 2020

Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and -resistant medulloblastoma cell lines

1 reference

12 December 2020

Enantioselective induction of cyclophosphamide metabolism by phenytoin.

1 reference

12 December 2020

Comparative pharmacokinetics of oral and intravenous ifosfamide/mesna/methylene blue therapy.

1 reference

12 December 2020

Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards

1 reference

12 December 2020

Phenotypically deficient urinary elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients

1 reference

12 December 2020

Identification of the class-3 aldehyde dehydrogenases present in human MCF-7/0 breast adenocarcinoma cells and normal human breast tissue

1 reference

12 December 2020

Transport of the new chemotherapeutic agent beta-D-glucosylisophosphoramide mustard (D-19575) into tumor cells is mediated by the Na+-D-glucose cotransporter SAAT1

1 reference

12 December 2020

Isophosphoramide Mustard and Its Mechanism of Bisalkylation.

1 reference

12 December 2020

Effect of renal insufficiency on the pharmacokinetics of cyclophosphamide and some of its metabolites

1 reference

12 December 2020

Ifosfamide clinical pharmacokinetics

1 reference

12 December 2020

The enigma of ifosfamide encephalopathy.

1 reference

12 December 2020

The partitioning of phosphoramide mustard and its aziridinium ions among alkylation and P-N bond hydrolysis reactions

1 reference

12 December 2020

Apoptosis induced by anticancer drugs

1 reference

12 December 2020

Metabolism of oxazaphosphorines

1 reference

12 December 2020

Oxidation of cyclophosphamide to 4-hydroxycyclophosphamide and deschloroethylcyclophosphamide in human liver microsomes

1 reference

12 December 2020

Relationship between DNA cross-links, cell cycle, and apoptosis in Burkitt's lymphoma cell lines differing in sensitivity to nitrogen mustard

1 reference

12 December 2020

Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy

1 reference

12 December 2020

Pharmacokinetics of (R)- and (S)-cyclophosphamide and their dechloroethylated metabolites in cancer patients

1 reference

12 December 2020

Decreased half life of cyclophosphamide in patients under continual treatment

1 reference

12 December 2020

10.2165/00003088-200038040-00001

Identifiers

DOI

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PubMed ID

10803453

Dimensions Publication ID

29 July 2017

0 references

1 reference

PubMed ID

10803453