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P-Glycoprotein, a gatekeeper in the blood-brain barrier
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
10837715
retrieved
29 July 2017
title
P-Glycoprotein, a gatekeeper in the blood-brain barrier
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
10837715
retrieved
29 July 2017
main subject
blood–brain barrier
1 reference
based on heuristic
inferred from title
author name string
Schinkel AH
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
10837715
retrieved
29 July 2017
language of work or name
English
0 references
publication date
1 April 1999
1 reference
stated in
Europe PubMed Central
PubMed ID
10837715
retrieved
29 July 2017
published in
Advanced Drug Delivery Reviews
1 reference
stated in
Europe PubMed Central
PubMed ID
10837715
retrieved
29 July 2017
volume
36
1 reference
stated in
Europe PubMed Central
PubMed ID
10837715
retrieved
29 July 2017
page(s)
179-194
1 reference
stated in
Europe PubMed Central
PubMed ID
10837715
retrieved
29 July 2017
issue
2-3
1 reference
stated in
Europe PubMed Central
PubMed ID
10837715
retrieved
29 July 2017
cites work
The biochemistry of P-glycoprotein-mediated multidrug resistance
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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inferred from DOI database lookup
The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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Biochemistry of multidrug resistance mediated by the multidrug transporter
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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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A mechanism for P-glycoprotein action in multidrug resistance: are we there yet?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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inferred from DOI database lookup
Genetic dissection of the function of mammalian P-glycoproteins
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake
1 reference
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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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Is the multidrug transporter a flippase?
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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Clinical studies with modulators of multidrug resistance.
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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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inferred from DOI database lookup
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
1 reference
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reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
based on heuristic
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Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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inferred from DOI database lookup
Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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inferred from DOI database lookup
Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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inferred from DOI database lookup
The Blood-Brain Barrier
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Crossref
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https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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inferred from DOI database lookup
Recent advances in blood-brain barrier transport
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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inferred from DOI database lookup
The blood-brain barrier
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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inferred from DOI database lookup
The blood-brain barrier. Transport across the cerebral endothelium
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
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Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
based on heuristic
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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
based on heuristic
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Specialized localization of P-glycoprotein recognized by MRK 16 monoclonal antibody in endothelial cells of the brain and the spinal cord.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Ultrastructural localization of P-glycoprotein on capillary endothelial cells in human gliomas
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular localization of P-glycoprotein in brain versus gonadal capillaries
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
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7 January 2021
based on heuristic
inferred from DOI database lookup
Interaction of drugs with P-glycoprotein in brain capillaries
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the multiple drug resistance gene (mdr-1) and epitope masking in chronic lymphatic leukaemia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Some monoclonal antibody reagents (C219 and JSB-1) to P-glycoprotein contain antibodies to blood group A carbohydrate determinants: a problem of quality control for immunohistochemical analysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MDR1 gene expression in brain of patients with medically intractable epilepsy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation and culture of human brain microvessel endothelial cells for the study of blood-brain barrier properties in vitro.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
P-glycoprotein deficiency in a subpopulation of CF-1 mice enhances avermectin-induced neurotoxicity
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a P-glycoprotein-deficient subpopulation in the CF-1 mouse strain using a restriction fragment length polymorphism.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HIV-1 protease inhibitors and the MDR1 multidrug transporter
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of the p-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: an in vivo microdialysis study in freely moving rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Decreased biotolerability for ivermectin and cyclosporin A in mice exposed to potent P-glycoprotein inhibitors.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A method to determine the ability of drugs to diffuse through the blood-brain barrier
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The functional role of P-glycoprotein in the blood-brain barrier
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0169-409X%2898%2900085-4
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0169-409X(98)00085-4
1 reference
stated in
Europe PubMed Central
PubMed ID
10837715
retrieved
29 July 2017
PubMed ID
10837715
1 reference
stated in
Europe PubMed Central
PubMed ID
10837715
retrieved
29 July 2017
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